Natural Killer cells in embryo - implantation

Harșa, Radu; Cluj-Napoca, România Pharmacy “Iuliu Haţieganu”; Nedelea, Irena; Surcel, Mihai; Stamatian, Florin; Romeo, Micu

doi:10.25083/rbl/24.5/789.797

Cited by 2 publications

(2 citation statements)

References 66 publications

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“…The process of embryo implantation, which is vital for a successful pregnancy, starts in a receptive endometrium. Endometrial receptivity and embryo-endometrial epithelium interactions for implantation are critical determinants of fertility, and a wide array of biological factors, including cytokines and chemokines, prostaglandins, adhesion molecules, growth factors, and others, orchestrate successful implantation [4,[12][13][14][15]. Several studies investigated the putative impact of endometrial cytokine levels on the outcome of in vitro fertilization in patients with recurrent implantation failure.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of IL-1β and TNF-α level in endometrial flush in patients with recurrent implantation failure

Harșa¹,

Pintea²,

Micu³

et al. 2022

J Clin Images Med Case Rep

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Infertility is defined as the inability to conceive within a year of regular unprotected intercourse affecting one in six couples. The most common causes of infertility are ovulatory dysfunction, male factor infertility, and tubal disease [1]. Unexplained Infertility (UI) and Recurrent Implantation Failure (RIF) are diagnoses based on failed pregnancy attempts with current infertility treatment options. UI is diagnosed when testing is inconclusive and RIF is diagnosed after three failed In Vitro Fertilization (IVF) cycles. UI is the absence of conception despite 12 months of unprotected intercourse, not explained by anovulation, poor sperm quality, tubal pathology or other known cause of infertility. RIF is defined by three failed IVF cycles in which one or two high-quality embryos are transferred in each cycle or by two failures in oocyte donor recipients after the transfer of good quality embryos [1]. UI is a common cause of infertility affecting 10-30% of infertile couples [2], while RIF is present in around 10% of in vitro fertilization (IVF) cycles [3].

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Section: Discussionmentioning

confidence: 99%

Evaluation of IL-1β and TNF-α level in endometrial flush in patients with recurrent implantation failure

Harșa¹,

Pintea²,

Micu³

et al. 2022

J Clin Images Med Case Rep

Self Cite

View full text Add to dashboard Cite

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“…ADCC is an immune mechanism through which Fc receptor-bearing effector cells (such as NK cells) can recognize and kill antibody-coated target cells [16]. NK cells and cytotoxic T lymphocytes take part in the implantation process through cytotoxic activity [17,18].…”

Section: Discussionmentioning

confidence: 99%

Lack of anti-paternal cytotoxic antibody production in the presence of spermatozoa in recurrent spontaneous abortion couples in contrast to fertile couples: a pilot study

Rafiee¹,

Sereshki²,

Alipour³

et al. 2021

Clinical and Experimental Obstetrics & Gynecology

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Background: Anti-paternal cytotoxic antibody (APCA) is a pregnancy alloantibody and is directed to paternal HLA molecules. A recent study showed that this antibody is produced in the presence of the husband's spermatozoa. Several studies have shown the absence or reduction of this antibody in the serum of recurrent spontaneous abortion (RSA) women. Note that the production of APCA has not been determined in the presence of spermatozoa in RSA women. A reason for the reduction or absence of APCA in the serum of RSA women may be the inability of the husband's spermatozoa to induce APCA production by lymphocytes. Therefore, this study aims to investigate APCA production by the wife's peripheral blood mononuclear cells (PBMCs) in the presence of the husband's spermatozoa in RSA couples. Methods: Ten RSA couples and ten fertile couples were included in this study. The wife's PBMCs (peripheral blood mononuclear cells) were cocultured with her husband's spermatozoa and the supernatant assessed for the presence of IgG by the ELISA method and APCA by complement-dependent cytotoxicity (CDC) assay. Results: Results showed that the production of IgG (median = 740 ng/mL in the fertile and 64 ng/mL in the RSA group) and APCA (median = 78% in the fertile and 48.5% in the RSA group) was significantly lower in the RSA group as compared to the fertile group. Conclusions: We concluded that a possible cause for APCA reduction in RSA women may be the inability of the husband's spermatozoa in induction of antibody production by the wife's PBMC. Nevertheless, large studies are needed to confirm the results of the present study.

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Natural Killer cells in embryo - implantation

Cited by 2 publications

References 66 publications

Evaluation of IL-1β and TNF-α level in endometrial flush in patients with recurrent implantation failure

Evaluation of IL-1β and TNF-α level in endometrial flush in patients with recurrent implantation failure

Lack of anti-paternal cytotoxic antibody production in the presence of spermatozoa in recurrent spontaneous abortion couples in contrast to fertile couples: a pilot study

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