Natural killer cells, ageing and cancer

Naumova, Elissaveta; Pawelec, Graham; Mihaylova, Anastasiya

doi:10.1007/s00262-016-1817-6

Cited by 16 publications

(9 citation statements)

References 7 publications

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“…Immunosenescence is known as changes in adaptive and innate immune systems during aging [ 42 ]. Many cells (such as Th1 responses, CD8 cytotoxic T cells, B cells, NK cells, and macrophages) are involved in Cancer immunosurveillance which is the ability of immune system to identify and kill new malignant cells [ 43 , 44 ]. However, malignant cells may gradually gain the ability to evade the immune system with the aging progress, which may lead to tumor progression [ 42 ].…”

Section: Discussionmentioning

confidence: 99%

Aging-related genes are potential prognostic biomarkers for patients with gliomas

Xiao

Zhang

et al. 2021

Aging

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Section: Discussionmentioning

confidence: 99%

Aging-related genes are potential prognostic biomarkers for patients with gliomas

Xiao

Zhang

et al. 2021

Aging

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“…NK cells are a key component of innate immunity and, to a large extent, promote the antitumor immune response [79,80]. The function of NK cells, such as immune surveillance, is also affected by age-related changes.…”

Section: Nk Cellsmentioning

confidence: 99%

Immunosenescence: a key player in cancer development

et al. 2020

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Immunosenescence is a process of immune dysfunction that occurs with age and includes remodeling of lymphoid organs, leading to changes in the immune function of the elderly, which is closely related to the development of infections, autoimmune diseases, and malignant tumors. T cell–output decline is an important feature of immunosenescence as well as the production of senescence-associated secretory phenotype, increased glycolysis, and reactive oxygen species. Senescent T cells exhibit abnormal phenotypes, including downregulation of CD27, CD28, and upregulation of CD57, killer cell lectin-like receptor subfamily G, Tim-3, Tight, and cytotoxic T-lymphocyte-associated protein 4, which are tightly related to malignant tumors. The role of immunosenescence in tumors is sophisticated: the many factors involved include cAMP, glucose competition, and oncogenic stress in the tumor microenvironment, which can induce the senescence of T cells, macrophages, natural killer cells, and dendritic cells. Accordingly, these senescent immune cells could also affect tumor progression. In addition, the effect of immunosenescence on the response to immune checkpoint blocking antibody therapy so far is ambiguous due to the low participation of elderly cancer patients in clinical trials. Furthermore, many other senescence-related interventions could be possible with genetic and pharmacological methods, including mTOR inhibition, interleukin-7 recombination, and NAD+ activation. Overall, this review aims to highlight the characteristics of immunosenescence and its impact on malignant tumors and immunotherapy, especially the future directions of tumor treatment through senescence-focused strategies.

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“…18 NK cells represent another important element of innate immunity responsible for the antitumor immune response. 19,20 NK cell functions (e.g., tumor immunology and surveillance) are also affected by increasing age. There are two subgroups of NK cells.…”

Section: Innate Immune Senescencementioning

confidence: 99%

The potential of cord blood to replenish young immune cells against cancer

Cheng

et al. 2021

Aging and Cancer

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The immune system of elderly individuals behaves differently from young adults, leading to a general assumption that the decline of immune system function increases the susceptibility to infectious and noninfectious diseases. This agerelated internal immune function failure, termed "immune senescence," contributes to the increment of morbidity and mortality associated with diseases in elderly populations. Cord blood is considered as a source of "young" immune cells for anti-infectious immunity and adoptive cancer immunotherapy. In this review, we describe immune aging and the application of cord blood for replenishing aging immune cells against neoplastic diseases.

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Natural killer cells, ageing and cancer

Cited by 16 publications

References 7 publications

Aging-related genes are potential prognostic biomarkers for patients with gliomas

Aging-related genes are potential prognostic biomarkers for patients with gliomas

Immunosenescence: a key player in cancer development

The potential of cord blood to replenish young immune cells against cancer

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