Natural killer cell neoplasms: A distinctive group of highly aggressive lymphomas/leukemias

Cheung, Moon‐Tong; Chan, John K.; Wong, K. F.

doi:10.1016/s0037-1963(03)00136-7

Cited by 127 publications

(98 citation statements)

References 79 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…9 NK-cell lymphomas are predominantly extranodal, and lymph node involvement at presentation or subsequently is uncommon. 10 Nasal NK-cell lymphoma Nasal NK-cell lymphomas refer to tumors occurring in the nose and the upper aerodigestive tract. [11][12][13][14][15] Males are predominantly affected, with the median age of presentation in the fifth decade.…”

Section: Classifications Of Nk-cell Lymphomasmentioning

confidence: 99%

“…Furthermore, chemotherapy is also advocated as part of the regimen for stage I/II disease, owing to high relapse rates after radiotherapy. 10 Hence, for medically fit patients with nasal NK-cell lymphomas, chemotherapy should be part of the treatment protocol. Age is the most important factor influencing the choice of chemotherapy.…”

Section: Chemotherapy Of Nk-cell Lymphomasmentioning

confidence: 99%

“…Therefore, the overall failure rate of chemotherapy reaches 67%. 10,48 The high failure rate of chemotherapy may be due to expression of the multidrug resistance (MDR) gene (P-glycoprotein). Actually, of all hematolymphoid cells, NK cells express the highest levels of P-glycoprotein.…”

Section: Chemotherapy Of Nk-cell Lymphomasmentioning

confidence: 99%

“…Radiotherapy, either as the initial treatment or as part of the chemotherapy regimen, is the single most important key to successful outcome. 10 …”

Section: Nk-cell Lymphoma Y-l Kwongmentioning

confidence: 99%

See 3 more Smart Citations

Natural killer-cell malignancies: diagnosis and treatment

2005

View full text Add to dashboard Cite

Section: Classifications Of Nk-cell Lymphomasmentioning

confidence: 99%

Section: Chemotherapy Of Nk-cell Lymphomasmentioning

confidence: 99%

Section: Chemotherapy Of Nk-cell Lymphomasmentioning

confidence: 99%

“…Radiotherapy, either as the initial treatment or as part of the chemotherapy regimen, is the single most important key to successful outcome. 10 …”

Section: Nk-cell Lymphoma Y-l Kwongmentioning

confidence: 99%

See 2 more Smart Citations

Natural killer-cell malignancies: diagnosis and treatment

2005

View full text Add to dashboard Cite

“…Występuje u młodszych pacjentów, najczęściej pochodzenia azjatyckiego; średni wiek to 39 lat [17,19,90]. Jest wyróżniona jako osobna jednostka chorobowa w klasyfikacji WHO i stanowi około 10% wszystkich nowotworów LGL [2,17].…”

Section: Przewlekłe Choroby Limfoproliferacyjne Z Komórek Nkunclassified

Białaczki z dużych ziarnistych limfocytów T i komórek naturalnej cytotoksyczności

Budziszewska¹

2015

Hematologia

View full text Add to dashboard Cite

Streszczenie Białaczki z dużych ziarnistych limfocytów (LGL) obejmują biologicznie heterogenną grupę rzadkich nowotworów układu chłonnego wywodzących się z limfocytów T (T-LGL) lub z komórek naturalnej cytotoksyczności (NK-LGL Abstract Leukemias of large granular lymphocytes (LGL) include a heterogeneous group of rare lymphoid malignancies derived from T cells (T-LGL) and natural killers (NK-LGL) T-LGL leukemia arises from long-term antigen stimulation and the survival of LGL cells is associated with constitutive activation of anti-apoptotic intracellular pathways JAK/STAT, RAS/RAF/MEK/ERK

show abstract

A Unique Presentation of an Epstein-Barr Virus–Associated Natural Killer/T-Cell Lymphoproliferative Disorder in a White Male Adolescent

Summers¹,

Samadashwily²,

Florell³

2011

Arch Dermatol

View full text Add to dashboard Cite

Background: Extranasal natural killer (NK)/T-cell lymphoma and aggressive NK-cell leukemia are strongly associated with Epstein-Barr virus (EBV) and most often occur in middle-aged individuals. Overlap between these 2 diagnoses is rare. In addition, pathologic findings for these 2 diagnoses are typically notable for necrosis, apoptosis, angioinvasion, and angiodestruction. Observations: We describe a 15-year-old male adolescent who had painful subcutaneous nodules and plaques over his anterior thighs, shins, and lower abdomen while receiving anti-tumor necrosis factor therapy with infliximab. He also was noted to have pulmonary nodules, liver nodules, hepatosplenomegaly, thrombocytopenia, and transaminitis. A skin biopsy revealed atypical small to intermediate-sized EBV-positive lymphoid cells of NK-cell origin infiltrating the subcutaneous adipose tissue, mimicking subcutaneous T-cell lymphoma. Similar atypical EBV-positive lymphocytes were noted in the bone marrow, liver, stomach, and colon. This patient had a rapidly fatal disease course. Conclusions: We report a unique clinical and histological presentation most consistent with an extranasal NK/ T-cell lymphoma and aggressive NK-cell leukemia overlap, although our case may represent a disease entity completely new to the literature. In addition, we report the first case to our knowledge of an EBV-positive NK/ T-cell lymphoma developing in the setting of tumor necrosis factor inhibitor therapy.

show abstract

Natural killer cell neoplasms: A distinctive group of highly aggressive lymphomas/leukemias

Cited by 127 publications

References 79 publications

Natural killer-cell malignancies: diagnosis and treatment

Natural killer-cell malignancies: diagnosis and treatment

Białaczki z dużych ziarnistych limfocytów T i komórek naturalnej cytotoksyczności

A Unique Presentation of an Epstein-Barr Virus–Associated Natural Killer/T-Cell Lymphoproliferative Disorder in a White Male Adolescent

Contact Info

Product

Resources

About