Natural killer cell cytotoxicity and lymphocyte perforin expression in veterans with posttraumatic stress disorder

Gotovac, Katja; Vidović, Anđelko; Vukušić, Herman; Krčmar, Tomislav; Sabioncello, Ante; Rabatić, Sabina; Dekaris, Dragan

doi:10.1016/j.pnpbp.2010.02.018

Cited by 27 publications

(16 citation statements)

References 67 publications

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“…Recent studies, which included soldiers deployed in conflict regions during the 90s [25] , or Croatian combat veterans [26] , found lower leukocyte GR expression in PTSD patients compared to controls. Another study of Croatian combat veterans found higher leukocyte GR expression in PTSD patients [27] , but the duration of PTSD symptoms in this study indicates that these patients were assessed later in the course of the disease than patients in the aforementioned study [26] .…”

contrasting

confidence: 64%

Repeated Assessments of Endocrine- and Immune-Related Changes in Posttraumatic Stress Disorder

Vidović¹,

Gotovac²,

Vilibić³

et al. 2011

Neuroimmunomodulation

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Objective: It is assumed that stress-related changes in the endocrine and immune systems are key mediators involved in the development of diseases associated with posttraumatic stress disorder (PTSD). Evidence suggests that those changes might be related to the duration of PTSD. The aim of our study was to investigate the differences in selected endocrine- and immune-related variables between PTSD patients and control subjects, and whether these differences persist over time. Methods: We assessed 39 Croatian war veterans with PTSD and 25 healthy volunteers (civilians without traumatic experience), all men, at two time points separated by 5.6 years (median; interquartile range: 5.4–6.3). Cortisol and prolactin levels were measured by radioimmunoassays while interleukin-6 and tumor necrosis factor-α were determined by enzyme-linked immunosorbent assays. Immune function was assessed by in vitro natural killer cell cytotoxicity (NKCC). Lymphocyte counts, immunophenotype and intracellular glucocorticoid receptor expression in various lymphocyte subsets were determined by three-color flow cytometry. Results: At the first assessment, moderate to large effect size estimates of differences between patients and controls were observed for most of the measured variables. Only prolactin levels and lymphocyte counts remained significantly elevated in PTSD patients at the second assessment with low to moderate effect size estimates of differences between patients and controls in other variables. Conclusion: Observed endocrine- and immune-related changes in PTSD over time may depend on the duration of the allostatic load posed by the disorder and its impact on interactions between the endocrine and immune systems involved in stress response.

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contrasting

confidence: 64%

Repeated Assessments of Endocrine- and Immune-Related Changes in Posttraumatic Stress Disorder

Vidović¹,

Gotovac²,

Vilibić³

et al. 2011

Neuroimmunomodulation

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“…In studies in adult trauma victims with PTSD, NKCC has generally been reported to be decreased, and was found to be increased in one study . In the present study, in the adolescents with PTSD‐P not accompanied by MDD, an increase in NKCC was observed, in contrast to general opinion.…”

Section: Discussioncontrasting

confidence: 53%

“…Consistent with our hypothesis, psychosocial factors were reported to influence the onset and persistence of asthma in children in a previous study. 10 In studies in adult trauma victims with PTSD, NKCC has generally been reported to be decreased, 16,21,[26][27][28] and was found to be increased in one study. 24 In the present study, in the adolescents with PTSD-P not accompanied by MDD, an increase in NKCC was observed, in contrast to general opinion.…”

Section: Compared Withmentioning

confidence: 89%

Immune system changes after sexual abuse in adolescents

Ayaydın

Abali

Akdeniz

et al. 2016

Pediatrics International

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“…Patients with TS do have enhanced responsiveness to acute stress (Chappell et al, 1994; Corbett et al, 2008), psychosocial stress negatively impacts their symptoms (Lin et al, 2007), and basal levels of cortisol negatively correlates with TS symptoms (Corbett et al, 2008). The immune changes that were previously reported in subjects with TS, including enhanced activity of T lymphocytes (Gabbay et al, 2009; Leckman et al, 2005; Moller et al, 2008), decreased numbers of regulatory T cells (Kawikova et al, 2007), and altered activity of natural killer cells (Du et al, 2006; Lit et al, 2007) are also present in patients with chronic stress conditions, such as post-traumatic stress disorder (Gill et al, 2009; Gotovac et al, 2010; Inoue-Sakurai et al, 2000; Sommershof et al, 2009). However, to our knowledge, no changes in IgG3 or IgM levels have been reported in chronic stress conditions.…”

Section: Discussionmentioning

confidence: 79%