Natural killer cell activity in women with recurrent miscarriage

Ebina, Yasuhiko; Nishino, Yukari; Deguchi, Masashi; Maesawa, Yoko; Nakajima, Yuki; Yamada, Hideto

doi:10.1016/j.jri.2016.10.068

Journal of Reproductive Immunology

2016

DOI: 10.1016/j.jri.2016.10.068

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Natural killer cell activity in women with recurrent miscarriage

Yasuhiko Ebina

Yukari Nishino

Masashi Deguchi

et al.

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2018

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“…Moreover, the increased activity of the decidua and the peripheral NK cells is linked with miscarriage. Recently, a cohort study (between 2009 and 2014) revealed that prepregnancy increased activities of peripheral blood NK cells are associated with the pathophysiology of RM (Ebina et al, 2016). Also, the blood NK cell activity has gain importance as a predictive marker of RM (Coulam et al, 1995a).…”

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confidence: 99%

NK cell frequency and cytotoxicity in correlation to pregnancy outcome and response to IVIG therapy among women with recurrent pregnancy loss

Ahmadi

Ghaebi

Abdolmohammadi-Vahid

et al. 2018

Journal Cellular Physiology

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Background Recurrent miscarriage (RM) has a multifactorial etiology mainly due to chromosomal abnormalities and immunological factors. Treating RM has remained to be a challenging issue and the role of intravenous immunoglobulin (IVIG) in treating RM is still controversial. Materials and Methods This study aimed to evaluate the changes in natural killer (NK) cells’ frequency and cytotoxicity in patients with RM who received the IVIG therapy. A total of 78 women with a history of three or more recurrent miscarriages were included and their peripheral blood was drawn in case of positive pregnancy test. On the same date, 400 mg/kg of IVIG was administrated intravenously in 38 women and it continued every four weeks through weeks 30–32 of gestation. The remaining 40 patients with RM were included to be the untreated control group. Then, the effects of IVIG on NK cell frequency, cytotoxic activity, and the expression of inhibitory and activating receptors in the patients with RM, pre and posttreatment were assessed. Results NK cells percentage and cytotoxicity were significantly reduced in the IVIG‐treated patients after 32 weeks of gestation (p < 0.0001). Expression levels of inhibitory receptors was increased, however, the expression levels of activating receptors were significantly decreased after the IVIG therapy. Pregnancy outcome after the treatment was significantly higher (86.8%) in the IVIG‐treated patients than controls (45%; p = 0.0006). Conclusion Our results suggested that women with RM may benefit from IVIG as a therapeutic approach and the frequency and functional status of peripheral NK cells may serve as a valuable predictive factor of therapy response.

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confidence: 99%

NK cell frequency and cytotoxicity in correlation to pregnancy outcome and response to IVIG therapy among women with recurrent pregnancy loss

Ahmadi

Ghaebi

Abdolmohammadi-Vahid

et al. 2018

Journal Cellular Physiology

View full text Add to dashboard Cite

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Natural killer cell activity in women with recurrent miscarriage

Cited by 1 publication

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NK cell frequency and cytotoxicity in correlation to pregnancy outcome and response to IVIG therapy among women with recurrent pregnancy loss

NK cell frequency and cytotoxicity in correlation to pregnancy outcome and response to IVIG therapy among women with recurrent pregnancy loss

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