Natural Killer Cell Activity and Interleukin-12 in Metabolically Healthy versus Metabolically Unhealthy Overweight Individuals

Kim, Minjoo; Kim, Minkyung; Yoo, Hye Jin; Lee, Jong Ho

doi:10.3389/fimmu.2017.01700

Cited by 8 publications

(8 citation statements)

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“…Similar to our results, some studies have reported a relationship between unhealthy metabolic status and reduced NK cell activity. 10 11 12 Kim, et al 10 showed that a metabolically unhealthy overweight group (higher BP and higher serum levels of triglyceride, glucose, glucose-related markers, and lower levels of HDL-C) had lower NK cell activity than a metabolically healthy overweight group. Lynch, et al 11 also reported that healthy obese patients had higher levels of NK cells, compared with unhealthy obese patients, and had similar NK cell levels to lean healthy controls.…”

Section: Discussionmentioning

confidence: 99%

“…Meanwhile, some researchers have shown decreased NK cell activity in metabolically unhealthy, obese individuals, and suggested that the immune system is involved in the different metabolic statuses of healthy and unhealthy obese individuals. 10 11 12 However, previous studies on this topic also employed small sample sizes, and the link between different metabolic phenotypes and immunity still remains unclear.…”

Section: Introductionmentioning

confidence: 99%

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Physical Inactivity and Unhealthy Metabolic Status Are Associated with Decreased Natural Killer Cell Activity

Jung

Park

et al. 2018

Yonsei Med J

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PurposeSeveral studies have reported relationships among physical activity, healthy metabolic status, and increased natural killer (NK) cell activity. However, large-scale data thereon are lacking. Thus, the present study aimed to assess NK cell activity according to physical activity and metabolic status.Materials and MethodsA cross-sectional study was performed on 12014 asymptomatic examinees. Using a patented stimulatory cytokine, NK cell activity was quantitated by the amount of interferon-γ secreted into the plasma by NK cells. Physical activity levels were assessed using the validated Korean version of the International Physical Activity Questionnaire Short Form.ResultsThe physically inactive group showed lower NK cell activity than the minimally active group (median, 1461 vs. 1592 pg/mL, p<0.001) and health-enhancing physically active group (median, 1461 vs. 1712 pg/mL, p=0.001). Compared to women with a body mass index (BMI) of 18.5–27.5 kg/m2, those with a BMI <18.5 kg/m2 had significantly lower NK cell activity (1356 vs. 1024 g/mL, p<0.001), and those with a BMI ≥27.5 kg/m2 tended to have lower NK cell activity (1356 vs. 1119 g/mL, p=0.070). Subjects with high hemoglobin A1c levels and low high-density lipoprotein cholesterol levels, as well as men with high blood pressure and women with high triglyceride levels, exhibited lower NK cell activity. Moreover, physical inactivity and metabolic abnormalities were independently associated with low NK cell activity, even after adjusting for confounders.ConclusionPhysical inactivity and metabolic abnormalities are associated with reduced NK cell activity. Immune systems may become altered depending on physical activity and metabolic status.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Physical Inactivity and Unhealthy Metabolic Status Are Associated with Decreased Natural Killer Cell Activity

Jung

Park

et al. 2018

Yonsei Med J

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“…IL-12 induces the expression of cytotoxic mediators and increased production of cytokines, especially IFN-γ, in NK cells, T cells, and natural killer T cells. The study of Kim et al [36], suggested that IL-12 levels in addition to NK cell activity could be better indicators for predicting individuals who are at early immune risk than serum levels of TNF-α, IL-6 and IL-1β. Along with our results, the study of obesity in the Mexican adult population revealed that, overweight and subjects with obesity (21 women with BMI ≥ 30 kg/m 2 ) had higher levels of IL-12 than a normal-weight group.…”

Section: Discussionmentioning

confidence: 99%

Inflammatory and endothelial dysfunction indices among Egyptian females with obesity classes I–III

et al. 2020

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Obesity is an alarming threat to health in Egypt. More than one in three Egyptians is obese, the highest rate in the world. We aimed to delineate the variability of inflammation and endothelial dysfunction markers among Egyptian females with different obesity classes. Out of 130 females, 70 were categorized into 3 obesity groups: Class I, BMI 30–34.9kg/m2; Class II, BMI 35–39.9 kg/m2 and Class III BMI ≥ 40kg/ m2, besides 60 control subjects. Anthropometric measurements were recorded and serum levels of tumor necrosis factor-alpha (TNF-α), C-reactive protein (CRP), interleukin 6 (IL-6), IL-12, soluble intercellular adhesion molecule 1 (sICAM-1) and soluble vascular adhesion molecule 1(sVCAM-1) were assessed among participants. In all three classes of obesity, significant increase (P <0.05) in BMI, waist-hip ratio, fat mass and body fat mass % were noted. CRP and sVCAM-1 levels were increased among the 3 obesity groups. TNF-α levels were increased in class II and III obesity groups. IL-6 and IL-12 levels were elevated in class I and class III groups. While, ICAM-1 levels were increased in class III obesity group. Based on individuals’ BMI, serum levels of TNF-α, CRP, IL-6, IL-12, sVCAM-1 and sICAM-1 are differentially altered with the progression of obesity. We strongly support the hypothesis that, as the obesity rate is still mounting, a subclinical inflammatory reaction has a role in pathogenesis of obesity and emphasize the elevation of endothelial dysfunction in individuals with obesity.

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“…Levels of the lipid panel, free fatty acids, a glucose-related panel, serum gamma-glutamyltransferase (gamma-GT) assayed via a modified Sanz method, and serum high-sensitivity C-reactive protein (hs-CRP) assayed via a latex-agglutination turbidimetric immunoassay were measured by a Hitachi 7600 autoanalyzer (Hitachi, Tokyo, Japan). Plasma adiponectin concentrations were measured by an enzyme immunoassay [ 11 ], and leptin was measured with a Human Leptin ELISA kit (Millipore, Darmstadt, Germany) by SpectraMax190 (Molecular Devices, Shanghai, China).…”

Section: Methodsmentioning

confidence: 99%

Effects of short-term dietary restriction on plasma metabolites and the subcutaneous fat area according to metabolic status in obese individuals: a case–control study

Jang

Han

Yoo

et al. 2021

Diabetol Metab Syndr

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Background Research elucidating the metabolic mechanisms that differentiate subtypes of obesity has been increasing. We aimed to investigate the effects of a 12-week dietary intervention on the metabolomic profiles of obese subjects. Methods Subjects followed a 12-week dietary restriction protocol consisting of a 300 kcal/day reduction in their usual caloric intake. Twenty-nine obese subjects were included and divided into two groups: the metabolic status maintenance group (n = 17, controls) and the metabolic status improvement group (n = 12, tests). We analyzed the somatometric and biochemical parameters and performed ultra-performance liquid chromatography-mass spectrometry analysis of the plasma metabolites. Results At 12 weeks, the fat percentage, whole fat area (WFA), subcutaneous fat area (SFA) at the L1 vertebra, and the levels of triglycerides, gamma-glutamyltransferase (gamma-GT), and leptin were markedly decreased in the metabolic status improvement group, while the level of high-density lipoprotein cholesterol increased compared with that in the metabolic status maintenance group. Metabolomic profiling at 12 weeks showed substantial differences in 4-aminobutyraldehyde (p = 0.005) and 4’-apo-β-carotenal (p = 0.024) between the two groups. Furthermore, an AUC value of 0.89 was obtained for the following seven featured biomarkers: triglycerides, gamma-GT, leptin, fat percentage, WFA, and SFA at the L1 vertebra, and 4-aminobutyraldehyde. Conclusions We demonstrated that 4-aminobutyraldehyde and related regional fat distribution parameters were strongly associated with obesity according to metabolic status. Thus, these biomarkers are potentially valuable in confirming the efficacy of short-term interventions and predicting metabolic status in obese individuals. Trials registration: This study was registered at ClinicalTrials.gov under NCT03135132 (registered 1 May 2017—retrospectively registered).

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Natural Killer Cell Activity and Interleukin-12 in Metabolically Healthy versus Metabolically Unhealthy Overweight Individuals

Cited by 8 publications

References 47 publications

Physical Inactivity and Unhealthy Metabolic Status Are Associated with Decreased Natural Killer Cell Activity

Physical Inactivity and Unhealthy Metabolic Status Are Associated with Decreased Natural Killer Cell Activity

Inflammatory and endothelial dysfunction indices among Egyptian females with obesity classes I–III

Effects of short-term dietary restriction on plasma metabolites and the subcutaneous fat area according to metabolic status in obese individuals: a case–control study

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