Natural Killer Cell Activity After Open‐Heart Surgery

Ryhänen, P.; Huttunen, K; Ilonen, Jorma

doi:10.1111/j.1399-6576.1984.tb02104.x

Cited by 52 publications

(11 citation statements)

References 20 publications

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“…METHYLPREDNISOLONE correlated with poor outcome in septic patients (23,24). Epidural anaesthesia is known to block or diminish the postoperative immunodepression but only for lower abdominal surgery and operation on the lower extremities (30)(31)(32). This can be explained by the absence of postoperative infections in our patients, which are known to be a potent stimulation of the production of these cytokines.…”

Section: Discussionmentioning

confidence: 82%

Effect of methylprednisolone on the cytokine response in patients undergoing lung surgery

Tønnesen

Wanscher

Höhndorf

et al. 1993

Acta Anaesthesiol Scand

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Tumour necrosis factor alpha (TNF alpha), interleukin-1 alpha (IL-1 alpha) and IL-6, when released in excess, have been suggested to be important host mediators of the immunoinflammatory response to injury and infections. Corticosteroids suppress this response in vitro. This study was undertaken to investigate if a single dose of methylprednisolone (MP) could modify the cytokine response in patients undergoing lung surgery. Twenty-one patients with lung cancer were allocated randomly to treatment with MP 30 mg/kg i.v. (MP group) or isotonic saline (control group). Patients were anaesthetized with a balanced anaesthesia combined with thoracic epidural anaesthesia. MP or saline was administered immediately before induction of anaesthesia. The cytokines in plasma were measured by ELISA, and blood samples were collected preoperatively, at the end of surgery, 4 h later, and 1 and 5 days postoperatively. All patients had detectable IL-6 in plasma. Compared to preoperative values, plasma IL-6 levels in the MP group increased from 114 pg/ml (12-350 pg/ml) (mean, range) to peak value 146 pg/ml (15-580 pg/ml) on the first postoperative day. In the control group, IL-6 levels increased from 99 pg/ml (17-350 pg/ml) preoperatively to 125 pg/ml (10-300 pg/ml) on the first postoperative day. The increases were not significant. TNF alpha was detectable in only two patients, one from each group. Low levels of IL-1 alpha were demonstrated in three patients in the MP group and in four patients in the control group.(ABSTRACT TRUNCATED AT 250 WORDS)

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Section: Discussionmentioning

confidence: 82%

Effect of methylprednisolone on the cytokine response in patients undergoing lung surgery

Tønnesen

Wanscher

Höhndorf

et al. 1993

Acta Anaesthesiol Scand

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“…Operative surgery with GA has been shown to depress patients' NK activity [17,18], According to the present results, NK activity was also depressed after cesarean sec tion in those parturients who received GA but was not significantly different from the preoperative level in those parturients who were operated on under EA. The findings show that further depression of NK activity after cesarean section in parturients whose NK cell function is otherwise already lowered [7] can be, at least partly, prevented by using EA.…”

Section: Discussionmentioning

confidence: 52%

“…To determine the NK activity, the patients' mononuclear cells as well as control cells taken from healthy volunteers were incubated in mi crotiter plates for 24 h with 'H-thymidine-labeled K 562 cells as target cells, as reported earlier [17]. The spontaneous incorporation of 'H-thymidine was de termined after incubating both the target cells and the effector (patient's) cells alone in culture medium.…”

Section: Laboratory Methodsmentioning

confidence: 99%

Natural Killer Cell Activity after Elective Cesarean Section under General and Epidural Anesthesia in Healthy Parturients and Their Newborns

Ryhänen

Jouppila

Lanning

et al. 1985

Gynecol Obstet Invest

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We studied the influence of elective cesarean section, under general and epidural anesthesia, on natural killer (NK) cell activity in 12 healthy parturients and in their newborns. The results of peripheral blood samples taken from the mothers before anesthesia and from the newborns 3 h after birth served as basal values against which the results of samples drawn on the 1 st and 5th days following delivery were compared. A significant (p < 0.05) decrease in the NK cell activity after surgery was found only in those mothers given general anesthesia. The differences between the studied groups were not, however, significant. NK activity in the peripheral blood samples of the newborns was not significantly different in the general anesthesia and in the epidural group during the follow-up period. The results show that the depression induced by operative stress on the NK cell function of parturients can be, at least partly, prevented by using epidural anesthesia.

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“…As reported in other forms of stress [10,19,21], we found a dramatic increase in natural killer (NK) cells during CPB and in the early post-operative period. In contrast to other studies [22,23] there was no decrease in NK cells 24 h after surgery.…”

Section: Discussionmentioning

confidence: 56%