Natural IVF cycles may be desirable for women with repeated failures by stimulated IVF cycles

Abstract

Mature oocyte retrieval followed by natural rather than stimulated in vitro fertilization might be a potential treatment for patients of advanced age when stimulated in vitro fertilization has been repeatedly unsuccessful.

IVF in Developing Economies and Low Resource Countries: An Overview

“…Up to December 31, 2012, three healthy tWE lab babies have been born vaginally. This proof-of-principle study [10], as called by the investigators, suggests that infertility care may now be ''universally accessible.'' The authors showed that the IVF methodology can be significantly simplified and can result in successful outcomes at levels that compare favorably to those obtained in high-resource programs.…”

“…Routine IVF (IVF), is slowly being challenged by simpler and more cost-effective methodologies. These include -Natural cycle IVF (nIVF) [10]. -Minimal stimulation IVF (msIVF) [11,12].…”

“…The proportion of high-quality and euploid embryos seems to be higher compared with conventional stimulation protocols, and the pregnancy rate per embryo transfer is comparable [10]. With the reduced costs, the better tolerability for patients, and the less time needed to complete an IVF cycle, these mild approaches are gaining a permanent foot-hold in cost-sensitive economies.…”

“…Klerkx et al [10] led a 11-month prospective study at Genk in which oocytes were cultured according to (a) regular IVF culturing, or (b) the tWE lab IVF culture system (50/50 %). The primary outcome parameter was embryo quality at day 3; secondary outcome parameters were embryo implantation rate and ongoing pregnancy rate.…”

Natural cycle IVF/IVM may be more desirable for poor responder patients after failure of stimulated cycles

“…With the increasing awareness of side effects of ovarian stimulation and better understanding of ovarian physiology in relation to ovarian follicular growth and maturation, IVF in natural cycles has gained great attention and interest for both normal responder and poor responder patients [2][3][4][5][6] because natural cycle offers a more physiological, less drug-oriented, lower risk and more patient-friendly approach. However, the efficacy of natural IVF is hampered by the high incidence of oocyte retrieval failure (16.7-71.4%) and the relatively low pregnancy rate per embryo transfer (ET) cycle (0-23.5%) [2,4,[7][8][9][10][11].…”