Natural Interferon Alfa for Treatment of Condylomata Acuminata

Friedman‐Kien, Alvin E.

doi:10.1001/jama.1988.03720040025021

Cited by 163 publications

(35 citation statements)

References 13 publications

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“…Complete clearance was seen in 62% of interferon-α patients compared to 21% of placebo-treated patients. 217 Intralesional interferon-α has also been used successfully in the treatment of recurrent oral warts in AIDS patients. 218 …”

Section: Intralesional Injection Of Interferonmentioning

confidence: 99%

An Armamentarium of Wart Treatments

Lipke¹

2006

Clinical Medicine & Research

284

295

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Patients and clinicians experience the frustration of cutaneous viral warts caused by infection with the human papilloma virus (HPV).Warts appear in various forms on different sites of the body and include common warts (verruca vulgaris), plane or flat warts, myrmecia, plantar warts, coalesced mosaic warts, filiform warts, periungual warts, anogenital warts (venereal or condyloma acuminata), oral warts and respiratory papillomas. Cervical infection with HPV is now known to cause cervical cancer if untreated. A review of the medical literature reveals a huge armamentarium of wart monotherapies and combination therapies. Official evidence-based guidelines exist for the treatment of warts, but very few of the reported treatments have been tested by rigorous blinded, randomized controlled trials.Therefore, official recommendations do not often include treatments with reportedly high success rates, but they should not be ignored when considering treatment options. It is the purpose of this review to provide a comprehensive overview of the wart treatment literature to expand awareness of the options available to practitioners faced with patients presenting with problematic warts. Warts of the genital tract carry a much more ominous and pernicious threat for women in particular. It has been estimated that up to 70% of sexually active women become infected during their lifetime with human papillomavirus (HPV), the infective agent that causes warts. 3-5 A causal role for HPV infections in cervical cancer has been documented beyond reasonable doubt. HPV DNA is present in virtually all cervical cancer cases worldwide, with it being detected in 99.7% of an international series of cervical cancers by genetic amplification techniques and in 100% of cases as confirmed by histological review. 6,7 Cervical cancer is the most frequent common cancer in developing countries and the second most common cancer in women worldwide. 3 The association between HPV infection and cervical cancer is so strong that HPV is now considered the first positive cause of any human cancer ever identified. 3This raises the level of concerns over HPV prevention, screening and treatment from that of a nuisance condition to that of a major public health concern. Attention is beginning to focus on the viral factors that determine persistence and neoplastic progression to cancer and the possible role of HPV in other nongenital cancers (e.g., skin, upper aerodigestive tract). [8][9][10][11][12][13][14][15][16][17] Patients with warts seek advice from general practitioners, pharmacists, naturopaths, allied health professionals, family or friends, dermatologists, gynecologists, obstetricians and pediatricians for treatment and may present with recalcitrant warts that have been previously treated with anything from folk remedies to hypnosis to over-the-counter medications to more aggressive clinic-based treatments. Unfortunately, even with years of medical literature on this subject, high-quality, level I evidence for the efficacy of almost all treatments is no...

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Section: Intralesional Injection Of Interferonmentioning

confidence: 99%

An Armamentarium of Wart Treatments

Lipke¹

2006

Clinical Medicine & Research

284

295

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“…5,6 In addition, adverse effects generally limit therapy to a maximum of 5 warts concurrently. 5,6 Because interferon is active against these warts and because imiquimod is active when applied topically, imiquimod has been examined as a potential treatment for anogenital warts with encouraging preliminary results. 7 This multicenter study compares the effectiveness and safety of 1% imiquimod cream, 5% imiquimod cream, and vehicle cream in the treatment of external anogenital warts.…”

Section: Safety Measurementsmentioning

confidence: 99%

“…However, use of this medication requires administration by multiple injections, and, although producing clearing rates of 36% to 62% without destruction of underlying skin, it is also associated with a significant recurrence rate of visible warts. 5,6 In addition, this therapy is expensive, produces systemic adverse effects, and requires multiple office visits.…”

Section: Commentmentioning

confidence: 99%

Self-administered Topical 5% Imiquimod Cream for External Anogenital Warts

Edwards¹

1998

Arch Dermatol

509

342

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“…Тем не менее использова-ние этого способа требует множественных инъек-ций и, хотя и приводит к устранению бородавок у 36-62% без изменения нижележащих слоев кожи, но также сопровождается высокой частотой реци-дива генитальных бородавок [18,19]. Кроме того, это дорогостоящая терапия, которая сопровождает-ся системными нежелательными эффектами и тре-бует большого количества визитов в клинику.…”

Section: клинические проявления и терапия пвиunclassified

“…Однако молекула ИФН плохо всасывается. Использование ИФН или подофиллина не рекомендуется, вслед-ствие их низкой эффективности и токсичности [15][16][17][18][19].…”

Section: клинические проявления и терапия пвиunclassified