Natural Insecticides from Actinomycetes and Other Microbes for Vector Mosquito Control

Paulraj, Michael Gabriel; Kumar, Pachaiyappan Saravana; Ignacimuthu, S.; Sukumaran, D.

doi:10.1007/978-81-322-2704-5_5

Cited by 12 publications

(8 citation statements)

References 58 publications

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“…Some antibiotics were identified to have insecticidal activities, including respiratory inhibitors such as antimycin A, patulin and piericidins, protein synthesis inhibitors such as cycloheximide or tenuazonic acid, and membrane-active agents such as some polyene macrolide antibiotics [ 12 , 61 , 62 ]. Streptomyces species can play a very important role in the biocontrol of insect pests, especially mosquitoes, by the direct production of active insecticide compounds [ 63 , 64 , 65 , 66 ]. Ivermectin is the most well-known insecticide produced by Streptomyces , which was initially used as an antiparasitic agent that has become a systemic treatment for the control of arthropod pests in livestock [ 67 ].…”

Section: Discussionmentioning

confidence: 99%

Biological Control of Aedes albopictus: Obtained from the New Bacterial Candidates with Insecticidal Activity

Dahmana

Sambou

Raoult

et al. 2020

Insects

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Vector-borne deadly pathogens cause more than 700,000 deaths annually. They are transmitted by several vectors, among which the mosquito is the most important. Chemical compounds often have devastating side effects, leading to the abandonment of the majority of them. Biological control has been performed by using formulations of Bacillus sphaericus and Bacillus thuringiensis, but their intensive use has led to the emergence of resistance. Currently, the development of new alternative molecules is urgently needed, in order to use them in mosaics or in rotation with already known insecticides for the control of vectors, especially mosquitoes. Here, we attempted to identify bacterial species with potential anti-mosquito actions. Among bacterial strains isolated from dry sandy soil from Senegal, eleven strains from the Bacillales and Actinomycetales orders were chosen for the entomopathogenic activity experiments. Then, we tested their secondary metabolites, which were obtained from the supernatant fraction, and their cell wall and cytoplasmic compounds, which were found in the pellet fraction, in Aedes albopictus larvae, and compared the larval mortality rate with that obtained by using a commercial product. A total of 4/11 (36.36%) of the isolated species exhibited insecticidal activity. B. nealsonii, which is not a well-known bacterium, had the highest larvicidal effect with 70% of the larval mortality, which is highlighted for the first time. The Streptomyces species we isolated seem to be potential new species, and 3/5 (60%) of them exhibited insecticidal activity. Our study reports provide potential candidates for the identification of active molecules to be developed for strengthening the biological control of infectious diseases agents transmitted by mosquitoes.

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Section: Discussionmentioning

confidence: 99%

Biological Control of Aedes albopictus: Obtained from the New Bacterial Candidates with Insecticidal Activity

Dahmana

Sambou

Raoult

et al. 2020

Insects

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“…Some antibiotics have been identified to have insecticidal activities, including respiratory inhibitors such as antimycin A, patulin and piericidins, protein synthesis inhibitors such as cycloheximide or tenuazonic acid, and membrane-active agents such as some polyene macrolide antibiotics 54,55,28 . Streptomyces species can play a very important role in the biocontrol of insect pests, especially mosquitoes, by the direct production of active insecticide compounds 56,57,58,59 . Ivermectin is the most well-known insecticide produced by Streptomyces, which was initially used as an antiparasitic agent that has become a systemic treatment for the control of arthropod pests in livestock 60 .…”

Section: Discussionmentioning

confidence: 99%

Insecticidal activity of the metabolites of sand soil bacteria in Northern Senegal

Dahmana¹,

Sambou²,

Raoult³

et al. 2020

Preprint

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BackgroundVector-borne deadly diseases cause more than 700,000 deaths annually. They are transmitted by several vectors, among which the mosquito is the most important. Chemical compounds often have devastating side effects, which has led to the abandonment of the majority of them. Biological control has been performed by using formulations of Bacillus sphaericus and Bacillus thuringiensis, but their intensive use has led to the emergence of resistance. Currently, there is an urgent need to develop new alterative molecules from bacteria to use in mosaics or in rotation with already known insecticides and bacteria for the control of vectors, especially mosquitos. Here, we attempted to identify bacterial species with potential anti-mosquito actions.ResultsAmong 208 strains isolated from dry sandy soil from Senegal, eleven bacterial strains from the Bacillus genus (5) and Actinomycetales order (6) were chosen for the following experiments. Then, we tested their secondary metabolites, which were obtained from the supernatant fraction, and their cell wall and cytoplasmic compounds, which were found in the pellet fraction, in 3rd and early 4th Aedes albopictus larvae instars and compared the larval mortality rate with that obtained by using a commercial product. A total of 4/11 (36.4%) of the isolated species exhibited insecticidal activity. B. nealsonii, which is not a well-known bacterium, had the highest larvicidal effect with 70% larval mortality, which highlighted for the first time. The Streptomyces spp. we isolated seem to be potential new species, and 3/5 (60%) of them exhibited insecticidal activity.ConclusionThe bacterial strains isolated in this study may be used to identify the molecular mechanisms of their insecticidal activity.

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“…Argemone mexicana acts as a larvicide against the dengue vector [102]. Microbial pesticides obtained from actinomycetes, Bacillus thuringiensis (Bt), and many other microorganisms are used as eco-friendly alternatives for mosquito control [103].…”

Section: Role Of Natural Agents In Dengue Vector Controlmentioning

confidence: 99%

The Dengue Vaccines: Assessment of Future Prospects, Treatment, and Vaccine Challenges

KALYANI

Thanushree

2020

Asian J Pharm Clin Res

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Objectives: As per the national survey data, the prevalence of dengue has been still rising consistently, and the burden of the disease is predominantly affecting the adults with progression toward the DF, dengue hemorrhagic fever, and dengue shock syndrome. The higher hospitalization rate result in massive mortality. Methods: Vector control alone cannot reduce the transmission of viral infection, so effective vaccine development is made high priority. Results: Several vaccine candidates including live attenuated, live chimeric, inactivated and many other vector vaccines are key elements needed to achieve the dengue public health targets. Global strategies like diagnosis, care management, outbreak preparedness and integrated surveillance, sustainable vector control, and future vaccine implementation are needed to be addressed. Conclusion: This review mainly describes the dengue treatment challenges, in addition to a brief discussion of dengue vaccine challenges and future outlook on dengue that might help in making efficacious vaccine in near future.

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Natural Insecticides from Actinomycetes and Other Microbes for Vector Mosquito Control

Cited by 12 publications

References 58 publications

Biological Control of Aedes albopictus: Obtained from the New Bacterial Candidates with Insecticidal Activity

Biological Control of Aedes albopictus: Obtained from the New Bacterial Candidates with Insecticidal Activity

Insecticidal activity of the metabolites of sand soil bacteria in Northern Senegal

The Dengue Vaccines: Assessment of Future Prospects, Treatment, and Vaccine Challenges

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