Natural IgE Production in the Absence of MHC Class II Cognate Help

McCoy, Kathy D.; Harris, Nicola L.; Diener, Philipp; Hatak, Sarah; Odermatt, Bernhard; Hangartner, Lars; Senn, Beatrice M.; Marsland, Benjamin J.; Geuking, Markus B.; Hengartner, Hans; Macpherson, Andrew J.; Zinkernagel, Rolf M.

doi:10.1016/j.immuni.2006.01.013

Cited by 108 publications

(116 citation statements)

References 61 publications

Supporting

Mentioning

110

Contrasting

Order By: Relevance

“…Nevertheless, Il13ra1 Ϫ/Ϫ mice can still mount a normal Th2 cytokine and IgE response. Baseline natural, but not antigenspecific, IgE has been recently attributed to a unique population of -germ-line transcript-positive B2 cells (25). We propose that IL-13R␣1 may control natural IgE production by this subpopulation of B cells, which may express the IL-13R␣1 and type II IL-4R along with or instead of ␥ c and the type I IL-4R.…”

Section: Discussionmentioning

confidence: 86%

Distinct roles for IL-13 and IL-4 via IL-13 receptor α1 and the type II IL-4 receptor in asthma pathogenesis

Munitz

Brandt

Mingler

et al. 2008

Proc. Natl. Acad. Sci. U.S.A.

240

253

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 86%

Distinct roles for IL-13 and IL-4 via IL-13 receptor α1 and the type II IL-4 receptor in asthma pathogenesis

Munitz

Brandt

Mingler

et al. 2008

Proc. Natl. Acad. Sci. U.S.A.

240

253

View full text Add to dashboard Cite

show abstract

“…In these studies, IgE + GC B cells showed an increased proportion of DZ GC cells compared with IgG1 + GC cells (41). Furthermore, a lack of MHC II expression on B cells was shown to be associated with higher IgE titers (45). Alternatively, or in addition, a shift toward enhanced Th2 differentiation in CD83 B-cKO mice could explain the enhanced IgE production.…”

Section: Discussionmentioning

confidence: 91%

CD83 Modulates B Cell Activation and Germinal Center Responses

Krzyzak

Seitz

Urbat

et al. 2016

The Journal of Immunology

View full text Add to dashboard Cite

CD83 is a maturation marker for dendritic cells. In the B cell lineage, CD83 is expressed especially on activated B cells and on light zone B cells during the germinal center (GC) reaction. The function of CD83 during GC responses is unclear. CD83−/− mice have a strong reduction of CD4+ T cells, which makes it difficult to analyze a functional role of CD83 on B cells during GC responses. Therefore, in the present study we generated a B cell–specific CD83 conditional knockout (CD83 B-cKO) model. CD83 B-cKO B cells show defective upregulation of MHC class II and CD86 expression and impaired proliferation after different stimuli. Analyses of GC responses after immunization with various Ags revealed a characteristic shift in dark zone and light zone B cell numbers, with an increase of B cells in the dark zone of CD83 B-cKO mice. This effect was not accompanied by alterations in the level of IgG immune responses or by major differences in affinity maturation. However, an enhanced IgE response was observed in CD83 B-cKO mice. Additionally, we observed a strong competitive disadvantage of CD83-cKO B cells in GC responses in mixed bone marrow chimeras. Furthermore, infection of mice with Borrelia burgdorferi revealed a defect in bacterial clearance of CD83 B-cKO mice with a shift toward a Th2 response, indicated by a strong increase in IgE titers. Taken together, our results show that CD83 is important for B cell activation and modulates GC composition and IgE Ab responses in vivo.

show abstract

“…Although IgE is a class-switched Ig-isotype requiring CD40L expression by T helper cells [20], total IgE levels are relatively high in mice or humans with T helper cell defects or complex human immunodeficiencies such as Wiskott Aldrich or Omenn syndrome [7,21]. Class-switching to IgE can happen either directly or in a stepwise fashion via classswitching first to IgG1 and then to IgE [22].…”

Section: Discussionmentioning

confidence: 99%

Low immunoglobulin E flags two distinct types of immune dysregulation

Elkuch

Greiff

Berger

et al. 2017

Clinical and Experimental Immunology

View full text Add to dashboard Cite

1These authors contributed equally to this study. SummaryDuring the last two decades, hyper-immunoglobulin (Ig)E syndromes have been characterized clinically and molecularly in patients with genetically determined primary immunodeficiencies. However, the detection of low IgE levels, defined here as below detection limit in the routine clinical immunology laboratory, has received little attention. We analysed the association of serum IgA, IgM and IgG levels (including IgG subclasses) with low, normal or high serum IgE levels in patients evaluated in a singlecentre out-patient immunodeficiency and allergy clinic. The correlation of serum IgE levels with IgG subclasses depended on the clinical phenotype. In patients with immunodeficiencies, IgE correlated with IgG2 and IgG4 but not with IgG3. In contrast, in patients referred for signs of allergy, IgE correlated with IgG3 but not with IgG2. A low IgE result was associated with low IgG3 and IgG4 in allergy referrals, while immunodeficiency referrals with a low IgE result had significantly lower IgG1, IgG2 and IgG4 levels. Hierarchical clustering of non-IgE immunoglobulin profiles (IgM, IgA, IgG, IgG1-4) validated that non-IgE immunoglobulin levels predict the clinic referral, i.e. phenotype, of low-IgE patients. These results suggesto guide the clinical management of patients with low serum IgE levels.

show abstract

Natural IgE Production in the Absence of MHC Class II Cognate Help

Cited by 108 publications

References 61 publications

Distinct roles for IL-13 and IL-4 via IL-13 receptor α1 and the type II IL-4 receptor in asthma pathogenesis

Distinct roles for IL-13 and IL-4 via IL-13 receptor α1 and the type II IL-4 receptor in asthma pathogenesis

CD83 Modulates B Cell Activation and Germinal Center Responses

Low immunoglobulin E flags two distinct types of immune dysregulation

Contact Info

Product

Resources

About