Natural Hydrogels, the Interesting Carriers for Herbal Extracts

Fathi, Milad; Ahmadi, Nadia; Forouhar, Ali; Atani, Saied Hamzeh

doi:10.1080/87559129.2021.1885436

Cited by 7 publications

(5 citation statements)

References 138 publications

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“…In hydrogel-based drug delivery, loading and controlled release of bioactive compounds are essential for effective delivery [104,105]. PVA hydrogel offers several methods for bioactive compound loading: (1) immersing freeze-dried hydrogels in a bioactive solution, (2) homogeneously mixing bioactive compounds with the polymer in the precursor solution, and (3) covalently tethering bioactive compounds to macromers before hydrogel formation [106].…”

Section: Classification Of Pva Hydrogel As Smart Delivery Mediamentioning

confidence: 99%

Bioactive compounds-loaded polyvinyl alcohol hydrogels: advancements in smart delivery media for biomedical applications

Luthfianti,

Waresindo,

Edikresnha

et al. 2024

Mater. Res. Express

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The paper initially focuses on the characteristics of Polyvinyl Alcohol (PVA) hydrogel as smart delivery media, such as chemical stability, biocompatibility, and capacity for controlled release of bioactive compounds. Then, it discusses the effect of loading bioactive compounds into PVA hydrogel, considering their stability of delivery media, controlled release, and targeted delivery, enhancing therapeutic outcomes. Loading bioactive compounds such as diphlorethohydroxycarmalol (DPHC), curcumin, carotenoids, andrographolide, and flavonoids into PVA hydrogels can enhance biomedical functionalities. These functionalities include improved drug delivery, wound dressing efficacy, tissue engineering potential, and contact lens applications. Further, while previous review papers have extensively covered aspects such as the source of bioactive compounds, extraction methods, synthesis of PVA hydrogel, and various biomedical applications, there remains a gap in the literature in which no studies have systematically explored the loading of bioactive compounds into PVA hydrogel. This targeted investigation distinguishes our work from previous studies and contributes a novel perspective to the expanding hydrogel market. In light of the projected compound annual growth rate of 7.15% in the hydrogel market from 2021 to 2028, this study provides a pioneering overview of recent advancements in bioactive compound-loaded PVA hydrogels. Finally, this review outlines the challenges in optimizing bioactive compound-loaded PVA hydrogels' performance and their biomedical application. In the future direction, this review explores their potential in smart delivery media, such as optimizing the loading efficiency and releasing kinetics to specific target therapeutic, crosslinking with double or triple network hydrogels, and convergence of nanotechnology with hydrogel that become frontiers in precision medicine.

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Section: Classification Of Pva Hydrogel As Smart Delivery Mediamentioning

confidence: 99%

Bioactive compounds-loaded polyvinyl alcohol hydrogels: advancements in smart delivery media for biomedical applications

Luthfianti,

Waresindo,

Edikresnha

et al. 2024

Mater. Res. Express

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“…Plants have been used for traditional remedies (e.g., bone defects and burn wounds) for centuries [99,100]. The bioactive phytochemicals of herbs, such as phenolic substances, essential oils, vitamins, and phytohormones, gain them tremendous features (e.g., antimicrobial, antifungal, anti-inflammatory, and antioxidant activity) and make them a rising star for antimicrobial therapies as greener and safer therapeutics [101][102][103][104][105][106]. Therefore, there have been a remarkable number of attempts in the literature to incorporate various herbal extracts, such as cinnamon [107], Cissus quadrangularis [108], and thymol [109], into collagen scaffolds to create an ideal and alternative antimicrobial biomaterial strategy for tissue regeneration purposes (Table 4).…”

Section: Herbal Extract-based Approachesmentioning

confidence: 99%

Recent Advances in Collagen Antimicrobial Biomaterials for Tissue Engineering Applications: A Review

Ersanlı

Tzora

Skoufos

et al. 2023

IJMS

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Biomaterial-based therapies have been receiving attention for treating microbial infections mainly to overcome the increasing number of drug-resistant bacterial strains and off-target impacts of therapeutic agents by conventional strategies. A fibrous, non-soluble protein, collagen, is one of the most studied biopolymers for the development of antimicrobial biomaterials owing to its superior physicochemical, biomechanical, and biological properties. In this study, we reviewed the different approaches used to develop collagen-based antimicrobial devices, such as non-pharmacological, antibiotic, metal oxide, antimicrobial peptide, herbal extract-based, and combination approaches, with a particular focus on preclinical studies that have been published in the last decade.

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“…The extracts of such plants can be used as potential cross-linkers to synthesize hydrogels with significant applications in the fields of health and the environment. 35,36 The primary rationale for employing whole plant extracts is their superior therapeutic efficacy compared with isolated single polyphenol, flavonoid, tannin, or anthocyanin compounds at equivalent doses. 37 The main interaction that enables the PVA polymer chains to remain entangled via cross-linking is hydrogen bonding between the hydroxyl groups of PVA and the hydroxyl or carboxyl groups of the cross-linkers.…”

Section: Introductionmentioning

confidence: 99%

A composite polyvinyl alcohol–medicinal plant extract crosslinked hydrogel: a novel soft system with excellent rhodamine B adsorption and significant antifungal activity

Tak,

Rashid,

Ahangar

et al. 2023

New J. Chem.

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Natural Hydrogels, the Interesting Carriers for Herbal Extracts

Cited by 7 publications

References 138 publications

Bioactive compounds-loaded polyvinyl alcohol hydrogels: advancements in smart delivery media for biomedical applications

Bioactive compounds-loaded polyvinyl alcohol hydrogels: advancements in smart delivery media for biomedical applications

Recent Advances in Collagen Antimicrobial Biomaterials for Tissue Engineering Applications: A Review

A composite polyvinyl alcohol–medicinal plant extract crosslinked hydrogel: a novel soft system with excellent rhodamine B adsorption and significant antifungal activity

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