Natural Host Defense Systems Active against Herpes Simplex Virus Infections

Role for major histocompatibility complex class I in regulating natural killer cell-mediated killing of virus-infected cells.

“…Our model focuses on HSV because of its well-characterized role in enhancing susceptibility to human NK cell-mediated cytotoxicity (6,(29)(30)(31)(32)(33). As targets, we have used the HLA class I-deficient B-lymphoblastoid cell line C1R and stable HLA class I transfectants of C1R expressing HLA-B27 (C1R-B27 cells), HLA-A3 (C1R-A3 cells), or HLA-Aw68 (ClR-Aw68 cells) (15,17,19,20).…”

In VitroCytotoxic Activity of Cord Blood NK Cells against Herpes Simplex Virus Type-1 Infected Purified Human Term Villous Cytotrophoblast

“…3Institute of Microbiology, Medical University, H-4012 Debrecen, Hungary. NK cell activity is correlated with susceptibility to HSV infection in newborn infants, thus demonstrating a central role of NK cells in the defense against HSV infection (5). Furthermore, the trophoblast has been found to produce IFNs (tro-EFN), predominantly of beta-type, in vitro after stimulation with viral inducers (6).…”

“…Based on the anatomical ultrastructure of the chorionic villous, it is conceivable that the immune cells in the fetal blood circulation may come in contact with the trophoblast cells, and thus several fetal immune effector mechanisms could be involved in the potential clearance of HSV-infected trophoblast cells. Natural killer (NK) cells and interferons (IFN) represent a first Une of defense against viral infections (5). In vitro studies show that impaired HSV-specifiĉ he Danish Cancer Society, Department of Vims and Cancer, Gustav Wieds vej 10, DK-8000 Aarhus C, Denmark. institute of Virology SAV, 84246 Bratislava, Slovak Republic.…”