Natural History of Small Renal Cell Carcinoma: Evaluation of Growth Rate, Histological Grade, Cell Proliferation and Apoptosis

Kato, Masanori; Suzuki, Takashi; Suzuki, Yoshio; Terasawa, Yasuo; Sasano, Hironobu; Arai, Yoichi

doi:10.1097/01.ju.0000136315.80057.99

Cited by 153 publications

(88 citation statements)

References 20 publications

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“…The reason for this difference is not clear. The gender distribution however is concordant with other studies both locally and internationally i.e., M: F=1.9-2:1 (Kato, 2004;Lafit, 2011).…”

Section: Discussionsupporting

confidence: 79%

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Clinicopathologic Patterns of Adult Renal Tumors in Pakistan

Hashmi

Ali²,

Hussain³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: Renal cancer is a serious public health problem which may be under reported and registered in our setup, since the Karachi cancer registry documented only 43 cases out of 4,268 incident cancer cases over 3 year duration. Therefore we aimed to determine the clinicopathologic characteristics of adult renal tumors in our setup. Materials and Methods: The study was conducted in histopathology department, Liaquat National Hospital and included total of 68 cases of adult renal tumors over 4 years. Detailed histopathologic characteristics of tumors were analyzed. Results: Mean age of patients was 56.4 (18-84) years. Renal cell carcinoma (RCC) was the most common cell type (78%) cases; followed by transitional/urothelial carcinoma (12.5%), leiomyosarcoma (4.7%), oncocytoma (1.6%), squamous cell carcinoma (1.6%) and high grade pleomorphic undifferentiated sarcoma (1.6%). Among 50 RCC cases; 62% were conventional/clear cell RCC (CCRCC) type followed by papillary RCC(PRCC), 24%; chromophobe RCC(CRCC), 6% and sarcomatoid RCC(SRCC), 8%. Mean tumor size for RCC was 7.2 cm. Most RCCs were intermediate to high grade (60% and 40% respectively). Capsular invasion, renal sinus invasion, adrenal gland involvement and renal vein invasion was seen in 40%, 18%, 2% and 10% of cases respectively. Conclusions: We found that RCC presents at an earlier age in our setup compared to Western populations. Tumor size was significantly larger and most of the tumors were of intermediate to high grade. This reflects late presentation of patients after disease progression which necessitates effective measures to be taken in primary care setup to diagnose this disease at an early stage.

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“…The reason for this difference is not clear. The gender distribution however is concordant with other studies both locally and internationally i.e., M: F=1.9-2:1 (Kato, 2004;Lafit, 2011).…”

Section: Discussionsupporting

confidence: 79%

“…In a local study conducted at SIUT, furhman's grade II was the most common (Latif and Mubarak, 2011). In a Japanese study, furhman's grade was I in 38%, II in 44.4% and III in 16% cases (Kato, 2004). In one Spanish study, nuclear grade 2 according to Fuhrman's Classification System accounts for 42.9% of the cases (Bocardo et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

Clinicopathologic Patterns of Adult Renal Tumors in Pakistan

Hashmi

Ali²,

Hussain³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…Due to the increased detection of tumours by imaging techniques, such as ultrasound (US) and computerised tomography (CT), the number of incidentally diagnosed RCCs has increased. These tumours are more often smaller and of lower stage (17,18). In this study there were 2 incidentally found renal tumours (pT1a and pT1b).…”

Section: Discussionmentioning

confidence: 90%

Urological malignancies: one-year audit from a tertiary referral centre

Sathesan

Prabath

Goonewardena

2010

Sri Lanka J. Urology

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Epidemiology of cancer depends on the population studied. The national cancer registry contains comprehensive cancer information for the whole population of a country. Regrettably, we do not have a national cancer registry in Sri Lanka. Herein we produce an audit of urological malignancies from a single urological unit in a tertiary referral centre. Patients and methodThis study was performed in a single urological unit of a tertiary referral centre. Newly diagnosed patients with histopathologically confirmed urological malignancies in the year 2009 were included in the study. The data were obtained retrospectively from the clinic notes and operation register. ResultsDuring the one year period 63 patients with urological malignancy were diagnosed. Table 1 shows the site of malignancy, the number of patients diagnosed and the sex distribution. AbstractObjective To study the clinicopathological characteristics of urological malignancies. Patients and MethodNewly diagnosed patients with urological malignancies in the year 2009 in a single urological unit of a tertiary referral centre were included in this retrospective study.Results During the study period there were 35 patients with carcinoma of the bladder; 17 patients with carcinoma of the prostate; 9 patients with renal malignancy; 1 patient with synchronous transitional cell carcinoma of the bladder and upper urinary tract; 1 patient with seminoma of the testis. Median age of the patients with primary bladder carcinoma was 65 years (range 46-82 years). Majority of the patients with primary bladder cancer were males (3.1:1) and had non-muscle invasive bladder cancer (72.7%). All patients with primary bladder cancer except one had transitional cell carcinoma (97%). Median age of the patients with carcinoma of the prostate was 70 years (range 60-81 years). All patients with carcinoma of the prostate had advanced disease at presentation. Median age of the patients with renal cell carcinoma (RCC) was 65 years (range 53-72 years). There is a 1.3:1 predominance of men over women. 85% of renal cell carcinomas were conventional renal cell carcinomas.

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“…With respect to this treatment paradigm, an important underlying assumption, one not supported by several case series, [17][18][19][20][21][22] is that all small renal masses have the universal capacity to grow and metastasize. This assumption, however, has several possible flaws.…”

Section: Discussionmentioning

confidence: 99%

Five‐year survival after surgical treatment for kidney cancer

Hollingsworth

Miller

Daignault

et al. 2007

Cancer

254

133

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BACKGROUND.Kidney cancer's rising incidence is largely attributable to the increased detection of small renal masses. Although surgery rates have paralleled this incidence trend, mortality continues to rise, calling into question the necessity of surgery for all patients with renal masses. Using a population‐based cohort, a competing risk analysis was performed to estimate patient survival after surgery for kidney cancer, as a function of patient age and tumor size at diagnosis.METHODS.With data from the Surveillance, Epidemiology, and End Results Program (1983–2002), a cohort was assembled of 26,618 patients with surgically treated, local‐regional kidney cancer. Patients were sorted into 20 age‐tumor size categories and the numbers of patients that were alive, dead from kidney cancer, and dead from other causes were tabulated. Poisson regression models were fitted to obtain estimates of cancer‐specific and competing‐cause mortality.RESULTS.Age‐specific kidney cancer mortality was stable across all size strata but varied inversely with tumor size. Patients with the smallest tumors enjoyed the lowest cancer‐specific mortality (5% for masses ≤4 cm). Competing‐cause mortality rose with increasing patient age. The estimated 5‐year competing‐cause mortality for elderly subjects (≥70 years) was 28.2% (95% confidence interval [CI]: 25.9%–30.8%), irrespective of tumor size.CONCLUSIONS.Despite surgical therapy, competing‐cause mortality for patients with renal masses rises with increasing patient age. After 5 years, one‐third of elderly patients (≥70 years) will die from other causes, suggesting the need for prospective studies to evaluate the role of active surveillance as an initial therapeutic approach for some small renal masses. Cancer 2007. © 2007 American Cancer Society.

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Natural History of Small Renal Cell Carcinoma: Evaluation of Growth Rate, Histological Grade, Cell Proliferation and Apoptosis

Abstract: The growth rate of RCCs correlates with apoptosis and grade. Most incidentally found RCCs are slow growing. However, those with certain histopathological features can grow rapidly and have a poor prognosis. More attention should be given to the observation of small renal masses.

Cited by 153 publications

References 20 publications

Clinicopathologic Patterns of Adult Renal Tumors in Pakistan

Clinicopathologic Patterns of Adult Renal Tumors in Pakistan

Urological malignancies: one-year audit from a tertiary referral centre

Five‐year survival after surgical treatment for kidney cancer

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