Natural History of Neuropsychiatric Manifestations of HIV Disease

Atkinson, J. H.; Grant, Igor

doi:10.1016/s0193-953x(18)30128-x

Cited by 96 publications

(58 citation statements)

References 33 publications

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“…5,16,32 It is well documented that individuals with HIV have higher rates of depression than individuals without HIV. 3,8,31 The relationship revealed in this study that depression may have an impact on virologic suppression is considerable. These findings demand further attention with longitudinal examination with regular depressive symptomatology screening to learn depressive patterns change over time and correlates of those changes.…”

Section: Discussionmentioning

confidence: 67%

“…2 It is well documented that individuals with HIV have significantly higher levels of psychological distress than the general population and are impacted by fluctuating levels of distress throughout the course of HIV infection. [3][4][5][6] During periods of distress, individuals with a chronic illness not only have lower quality of life, but also have more difficulty engaging in behaviors that are health promoting. [7][8][9] There has been little documented that examined the effect highly active antiretroviral therapy (HAART) on depression among individuals with HIV.…”

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confidence: 99%

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Routine Screening for Depression: Identifying a Challenge for Successful HIV Care

Shacham

Nurutdinova

Satyanarayana

et al. 2009

AIDS Patient Care and STDs

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Individuals with HIV experience fluctuating levels of distress throughout the course of HIV infection. This study was conducted to examine the associations of depressive symptomatology with HIV disease in a cohort of individuals who are engaged in routine medical care. This cross-sectional study examined the prevalence of depressive symptoms that were measured as part of a standard of care behavioral assessment among individuals at an urban HIV clinic in the Midwest. Demographic characteristics, depressive symptoms, and behavioral risk factors were collected. A total of 514 individuals participated in the study, the majority of whom was male and African American. One quarter of the sample endorsed symptoms of other depressive disorder, while 18% (n ¼ 91) endorsed symptoms of major depressive disorder as measured by the Patient Health Questionnaire-9 (PHQ-9). Among those on highly active antiretroviral therapy (HAART), individuals who were unemployed (adjusted odds ratio [AOR] ¼ 2.47, 95% confidence interval [CI] ¼ 1.54, 3.97), had a minor dependent (AOR ¼ 2.17, 95% CI ¼ 1.25, 3.77), or between the ages of 18 and 34 years (AOR ¼ 1.37, CI ¼ 1.03, 1.94) and detectable HIV viral load (AOR ¼ 2.52, 95% CI ¼ 1.22, 5.23) were more likely to report depressive disorder symptoms when controlling for age, gender, race, and education. Nearly 15% of the sample endorsed having suicidal thoughts at least once in the past two weeks. Regardless of HAART prescription, individuals who were unemployed had a higher likelihood of expressing suicidal ideation (AOR ¼ 3.43, 95% CI ¼ 1.66, 7.06). Given the association between depressive symptomatology and poor rates of HIV viral suppression, screening and appropriate interventions for depressive symptoms are warranted in the HIV outpatient setting to improve outcomes.

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Section: Discussionmentioning

confidence: 67%

mentioning

confidence: 99%

Routine Screening for Depression: Identifying a Challenge for Successful HIV Care

Shacham

Nurutdinova

Satyanarayana

et al. 2009

AIDS Patient Care and STDs

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“…15,16 Quando analisados prospectivamente, 10% a 25% dos homossexuais masculinos infectados apresentarão uma síndro-me depressiva no período de 2 anos. 17 A depressão maior em pacientes HIV positivos está associada a vários fatores: (1) descoberta da infecção, início dos sintomas físicos, progressão da doença e das limitações por ela impostas e as complexas questões psicossociais envolvidas; (2) invasão do sistema nervoso central pelo HIV, por infecções oportunistas ou por tumores intracranianos; (3) desencadeamento de episódio depressivo em populações vulneráveis (homossexuais e UDI). 5,18 A Tabela 1 resume os fatores de risco para depressão, observados nos estudos analisados, em indivíduos infectados pelo HIV: [19][20][21] Tabela 1 -Fatores de risco para depressão em indivíduos infectados pelo HIV.…”

Section: Epidemiologia E Fatores De Riscounclassified

Tratamento de depressão em indivíduos infectados pelo HIV

Malbergier¹,

Schöffel

2001

Rev. Bras. Psiquiatr.

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A infecção pelo HIV/Aids é freqüentemente associada a transtornos psiquiátricos. Dentre eles, a depressão é o mais comum. O diagnóstico e o tratamento dos transtornos depressivos são fundamentais para melhorar a qualidade de vida desses pacientes. Esta revisão tem como objetivo sintetizar e discutir os resultados mais importantes da literatura a respeito das particularidades do tratamento dos transtornos depressivos em indivíduos infectados pelo HIV. São discutidos a epidemiologia, o quadro clínico, a influência da depressão na evolução da infecção, o tratamento farmacológico com antidepressivos, testosterona e psicoestimulantes e a interação farmacológica entre os antidepressivos e benzodiazepínicos e as drogas antivirais. Conclui-se que o tratamento antidepressivo nessa população é eficaz, seguro e não promove imunossupressão nos indivíduos afetados.HIV. Aids. Depressão. Antidepressivos.HIV/AIDS infection is frequently associated with psychiatric disorders, especially depression. The diagnosis and treatment of depression are essential to improve quality of life in these individuals. This review intends to summarize and discuss the most important results in the literature about the treatment of depression in HIVinfected individuals. The epidemiology, clinical presentation, contribution of depression on HIV infection, pharmacological treatment with antidepressants, testosterone, and psychostimulant drugs, and pharmacological interactions between antidepressants, benzodiazepines, and antiviral medications are discussed. The conclusion drawn from this study is that the treatment of depression in this population is effective, safe and does not promote immunosupression. A Aids tem se tornado objeto de interesse por parte de psiquiatras, psicólogos e outros profissionais de saúde mental essencialmente por duas razões: o tropismo do HIV pelo sistema nervoso central (SNC) e o impacto psicológico do diagnóstico e da evolução da infecção nos indivíduos afetados. Diante disso, desenvolveram-se duas grandes áreas de interesse. A primeira situa-se nos limites da psiquiatria e da neurologia e tem como foco de interesse as conseqüências clínicas da ação do HIV e de outras patologias associadas (p. ex., neurotoxoplasmose e HIV. AIDS. Depression. Antidepressive agents. Resumo

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“…For example, rates of depression among HIV-positive men and women have been reported to be twice as high as the general population (Atkinson & Grant, 1994;Lyketsos et al, 1996), with rates of diagnosable depressive disorders estimated between 4 and 14% (Lyketsos et al, 1996). Prevalence rates of post-traumatic stress disorder have been reported to be as high as 62% and significantly related to the progression of HIV (Kimerling et al, 1999).…”

Section: Introductionmentioning

confidence: 99%

The effect of perceived and actual social support on the mental health of HIV-positive persons

2007

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The purpose of this paper is to compare the ways in which perceived and actual social support affect the mental health of gay men, straight or bisexual men, and women living with HIV/AIDS. Participants included 125 women and 232 men with an HIV-positive or AIDS diagnosis involved in three larger investigations of HIV, disclosure and mental health. Results suggest each sub-group experienced perceived social support as significantly predictive of better mental health while the effect of actual social support was minimal.

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Natural History of Neuropsychiatric Manifestations of HIV Disease

Cited by 96 publications

References 33 publications

Routine Screening for Depression: Identifying a Challenge for Successful HIV Care

Routine Screening for Depression: Identifying a Challenge for Successful HIV Care

Tratamento de depressão em indivíduos infectados pelo HIV

The effect of perceived and actual social support on the mental health of HIV-positive persons

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