Natural history of neck disease in patients with squamous cell carcinoma of oropharynx and pharyngolarynx

Bataini, J. P.; Bernier, Jacques; Brugère, J; Jaulerry, C; Picco, C.; Brunin, F.

doi:10.1016/s0167-8140(85)80033-5

Cited by 66 publications

(24 citation statements)

References 17 publications

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“…If clinically positive lymph nodes disappear completely during or after radiation therapy, the neck dissection can probably be withheld because the probability of neck failure in these patients is below 10%. Experience has demonstrated that isolated neck recurrence rates (meaning no evidence of distant or primary disease) after radiotherapy or CCRT were 6% to 10% when the patient had enjoyed a complete or near-complete response [20][21][22][23]. This result is roughly comparable to the 8% neck recurrence rate in pathologically negative necks (Fig.…”

Section: Radiation Plus Chemotherapy: Role Of Neck Dissection In Compmentioning

confidence: 79%

Controversies in management of the neck in head and neck cancer

Garg

Beitler

2004

Curr. Treat. Options in Oncol.

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As definitive external radiation and multimodality organ preservation strategies (eg, combined chemotherapy and radiation therapy ) improve, the role of surgery is being re-examined in the management of locally advanced head and neck cancer. Consensus regarding the use of neck dissections for complete responders and incomplete responders has yet to be achieved and the data are surprisingly controversial. A possible benefit from neck dissection after a complete response of the primary tumor after CCRT or definitive external radiation for advanced squamous cell carcinoma of the head and neck may only be anticipated in patients with persisting subclinical neck disease who have no other sites of disease. Some clinicians have even argued that the salvage rate for clinically detectable residual neck disease does not justify neck dissection. Randomized data addressing these questions and a trial addressing the accuracy of new imaging modalities, such as postchemotherapy and postradiation positron emission tomography scanning, across multiple institutions would be appropriate. As a department, we are aggressive in our treatment of isolated residual neck disease after CCRT or definitive external radiation and for patients initially diagnosed with N3 nodal disease. We are investigating the use of adjuvant neck brachytherapy at the time of neck dissection and we are pleased with our early results.

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Section: Radiation Plus Chemotherapy: Role Of Neck Dissection In Compmentioning

confidence: 79%

Controversies in management of the neck in head and neck cancer

Garg

Beitler

2004

Curr. Treat. Options in Oncol.

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“…Tumour size (volume) has been shown to be a significant predictor of a given patient's potential for cure by RT (3)(4)(5)16) and is part of current staging systems (T-and N-stage) for upper aerodigestive tract malignancies (17)(18)(19). In fact, the paramount importance of tumour volume has been stressed in the recent edition of the UICC classification in particular with regard to the neck nodes.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, the subjectivity of establishing fixation (N3-1978 edition) has been eliminated. In particular with regard to neck nodes, there is ample evidence in the current literature that the extent (volume) of lymph nodal metastasis is of extreme importance in terms of ultimate control (3,(24)(25)(26)(27)(28). Most authors on laryngeal carcinoma even postulate that Nstage is the major determinant of patient outcome (3,24,26,28,29).…”

Section: Discussionmentioning

confidence: 99%

“…This organization (UICC) revised its system in 1987 thoroughly and for head and neck cancer in particular with respect to the classification of cervical lymph node metastasis (2). It has been shown that for the curability of tumours, volume of disease is of paramount importance, specifically when radiation therapy (RT) is used as a single modality treatment (3)(4)(5). In the recently revised UICC classification system, measured size, that is volume, is now used specifically to stratify neck nodes into different subclasses, which is in marked contrast to the 1978 edition ( Table I).…”

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confidence: 99%

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Cancer of the Supraglottic Larynx with Neck Node Metastisis Treated by Radiation Therapy Only the revised 1987 UICC classification system as prognostic indicator

Levendag¹,

Veeze-Kuijpers²,

Knegt³

et al. 1990

Acta Oncologica

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“…1 Metastatic lymph node involvement in the neck is dependent on the size of the primary tumor, increasing with T stage. 2 Unfortunately, the proliferation of cancer within the nodes often leads to uncontrolled regional disease and mortality. Cancer in the cervical lymph nodes reduces the chances of a patient's curability by 50% and is responsible for 50%-95% of recurrent disease.…”

Section: Introductionmentioning

confidence: 99%

Does Age Affect the Size of Metastatic Lymph Nodes in Head and Neck Cancer?

Süslü¹,

Hoşal²,

Tezel³

et al. 2013

UHOD

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The aim of the study was to determine if age plays a role in the size of metastatic lymph nodes in elderly patients with squamous cell carcinoma of the head and neck (HNSCC). In 180 HNSCC patients with metastatic lymph nodes, largest metastatic lymph node (SMLN), diameter of metastatic deposit (DMD), and the ratio of non-metastatic lymphoid tissue to the size of largest metastatic lymph node (RNML) were recorded. The patients were divided into 2 groups (group 1: <65 years; group 2: ≥65 years) to analyse the correlation between SMLN, DMD, RNML, and age. ,Median SMLN and DMD in the entire study population was 17 mm and 15 mm, respectively. There was not a significant correlation between age, and SMLN or DMD (r= 0.039 and P= 0.64, and r= 0.055 and P= 0.54, respectively). Extracapsular spread (ECS) was observed in 57.6% of patients in group 2 and in 50.4% of patients in group 1. Although ECS was more frequent in group 2, there was not a significant difference in SMLN, RMLN and DMD between the 2 groups (P > 0.05). In conclusion, age did not affect the size of metastatic lymph nodes in the patients with HNSCC.Keywords: Head and neck neoplasms, Squamous cell carcinoma, Lymph node, Metastases, Aging, Immunity ÖZET Bafl Boyun Kanserlerinde, Yafl Metastatik Lenf Nodu Büyüklü¤ünü Etkiliyor mu?Bu çal›flman›n amac›, bafl boyun skuamöz hücreli kanserinde, ileri yafl›n metastatik lenf nodu büyüklü¤ü üzerinde etkisi olup olmad›¤›n› araflt›rmakt›r. 180 bafl boyun kanserli ve metastatik lenf nodu tespit edilen hastalarda, en büyük metastatik lenf nodunun çap› (BLN), lenf nodu içerisinde metastatik tümör oda¤›n›n çap› (TO) ve tümör taraf›ndan tutulmam›fl k›sm›n tüm lenf noduna hacim yüzdesi (NAY) hesaplanm›flt›r. Hastalar 65 yafl alt› (grup 1) ve üstü (grup 2) olmak üzere iki gruba ayr›lm›flt›r. Bu iki grup incelenerek, yafl ile BLN, TO ve NAY de¤erleri aras›nda korelasyon olup olmad›¤› analiz edilmifltir. Tüm çal›flma grubunda, BLN ve TO de¤erleri s›ras›yla 17 mm and 15 mm idi. Yafl ile BLN ve TO aras›nda istatistiksel olarak anlaml› fark bulunmad› (r= 0.039, P= 0.64, ve r= 0.055 and P= 0.54, s›ras›yla). Ekstrakapsüler yay›l›m (EKY), grup 1'deki hastalar›n %50.4'ünde; grup 2'deki hastalar›n %57.6's›nda tespit edildi. EKY, grup 2'deki hastalarda daha s›kl›kla gözlenmesine ra¤men, her iki grup aras›nda BLN, TO ve NAY aç›s›ndan her iki grup aras›nda istatistiksel olarak anlaml› fark bulunmam›flt›r (P> 0.05). Sonuç olarak, Bafl boyun kanserli hastalarda, yafl›n metastatik lenf nodu büyüklü¤ünü etkilemedi¤i ortaya konmufltur.Anahtar Kelimeler: Bafl boyun kanseri, Skuamöz hücreli kanser, Lenf nodu, Metastaz, Yafl, ‹mmünite ULUSLARARASı HEMATOLOJI-ONKOLOJI DERGISI ARTICLE

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Natural history of neck disease in patients with squamous cell carcinoma of oropharynx and pharyngolarynx

Cited by 66 publications

References 17 publications

Controversies in management of the neck in head and neck cancer

Controversies in management of the neck in head and neck cancer

Cancer of the Supraglottic Larynx with Neck Node Metastisis Treated by Radiation Therapy Only the revised 1987 UICC classification system as prognostic indicator

Does Age Affect the Size of Metastatic Lymph Nodes in Head and Neck Cancer?

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