Natural History of Multidrug-Resistant <i>Acinetobacter baumannii</i> Carriage in Intensive Care Units

Doi, Yohei; Kandiah, Sheena; Hariri, Rahman; Harrison, Lee H.

doi:10.1086/665713

Cited by 4 publications

(4 citation statements)

References 4 publications

(5 reference statements)

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“…It has even been suggested that we are closer to the end of the antibiotic era with Acinetobacter than with methicillin-resistant Staphylococcus aureus [56] . The increased occurrence of A. baumannii MDR strains in the Burn Wound Center of Queen Astrid Military Hospital (Brussels, Belgium) and in health care settings worldwide in general [9] , [16] prompted us to search for alternative solutions to the problem, such as bacteriophages.…”

Section: Resultsmentioning

confidence: 99%

“…The ability to form biofilms and extended survival on environmental surfaces along with broad resistance to antibiotics puts A. baumannii on the list of the medically most important pathogens [4] . The known risk factors for A. baumannii colonization or infection include prolonged hospitalization, intensive care unit (ICU) admission, recent surgical procedures, parenteral nutrition, invasive procedures, nursing home residence, and previous broad-spectrum antibiotic use [5] – [9] .…”

Section: Introductionmentioning

confidence: 99%

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Characterization of Newly Isolated Lytic Bacteriophages Active against Acinetobacter baumannii

et al. 2014

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Based on genotyping and host range, two newly isolated lytic bacteriophages, myovirus vB_AbaM_Acibel004 and podovirus vB_AbaP_Acibel007, active against Acinetobacter baumannii clinical strains, were selected from a new phage library for further characterization. The complete genomes of the two phages were analyzed. Both phages are characterized by broad host range and essential features of potential therapeutic phages, such as short latent period (27 and 21 min, respectively), high burst size (125 and 145, respectively), stability of activity in liquid culture and low frequency of occurrence of phage-resistant mutant bacterial cells. Genomic analysis showed that while Acibel004 represents a novel bacteriophage with resemblance to some unclassified Pseudomonas aeruginosa phages, Acibel007 belongs to the well-characterized genus of the Phikmvlikevirus. The newly isolated phages can serve as potential candidates for phage cocktails to control A. baumannii infections.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Characterization of Newly Isolated Lytic Bacteriophages Active against Acinetobacter baumannii

et al. 2014

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“…19 We previously reported that importation by patients colonized elsewhere constitutes the main source of MDR A baumannii in ICUs, and thus screening cultures obtained at admission were likely to be more cost-effective than subsequent screening cultures. 20 On the other hand, the prevalence of A baumannii among noncritically-ill patients on admission was very low. 21 Active surveillance should therefore focus on high-risk populations when it is implemented.…”

Section: Discussionmentioning

confidence: 99%

Risk factors for acquisition of multidrug-resistant Acinetobacter baumannii among cancer patients

Fukuta

Muder

Agha

et al. 2013

American Journal of Infection Control

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“…Our study was not designed to assess carriage of P. aeruginosa or A. baumannii outside the digestive tract, although it has been demonstrated that both species are colonizing other sites [ 24 ]. It was considered that results from this first study would help to decide if more focused studies are needed.…”

Section: Discussionmentioning

confidence: 99%

First multicenter study on multidrug resistant bacteria carriage in Chinese ICUs

et al. 2015

BMC Infect Dis

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BackgroundThe importance of multidrug-resistant organisms (MDRO) in Chinese hospitals is not clearly delineated. Thus we sought to assess the prevalence of MDRO in Chinese intensive care units (ICUs).MethodsProspective study of inpatients admitted consecutively to eight ICUs in four Chinese cities in 2009–10. Admission and weekly screenings were performed by using selective media for methicillin resistant Staphylococcus aureus, extended-spectrum beta-lactamase-producing Enterobacteriaceae, Acinetobacter and Pseudomonas aeruginosa. For the two latters, resistance to ceftazidime defined MDRO. Backward logistic regression models were designed to assess factors independently associated with MDRO carriage on admission and MDRO acquisition within ICUs.Results686 patients were included, and the MDRO prevalence rate on admission was 30.5 % (32.7 % for ESBL-positive Enterobacteriaceae, 3.2 % for MRSA). Antibiotic treatment prior to ICU admission was independently associated with carriage on admission (OR: 1.4) in multivariate analysis. A total of 104 patients acquired ≥1 MDRO in ICU (overall attack rate: 23.7 %; 14.9 % for ESBL-positive Enterobacteriaceae, and 5.1 % for MRSA). The MDRO attack rate increased from 13.2 % in the first week to 82.1 % for ICU stay > 3 weeks. Duration of antibiotic exposure (OR: 1.16; 1.1–1.2) and prior antibiotic treatment before ICU (OR: 2.1; 1.1–3.3) were associated with MDRO acquisition in multivariate analysis. The MDRO prevalence rate on ICU discharge was 51.2 % and the global prevalence density rate 71 per 1000 hospital-days.ConclusionMore than one out of two patients was MDRO carrier on ICU discharge in Chinese hospitals. This is the result of the combination of a high MDRO prevalence rate on ICU admission and a high MDRO acquisition rate within ICU.

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Natural History of Multidrug-Resistant Acinetobacter baumannii Carriage in Intensive Care Units

Cited by 4 publications

References 4 publications

Characterization of Newly Isolated Lytic Bacteriophages Active against Acinetobacter baumannii

Characterization of Newly Isolated Lytic Bacteriophages Active against Acinetobacter baumannii

Risk factors for acquisition of multidrug-resistant Acinetobacter baumannii among cancer patients

First multicenter study on multidrug resistant bacteria carriage in Chinese ICUs

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