Natural history of mitral valve prolapse

Zuppiroli, Alfredo; Rinaldi, Michael; Kramer-Fox, Randi; Favilli, Silvia; Roman, Mary J.; Devereux, Richard B.

doi:10.1016/s0002-9149(99)80718-8

Cited by 151 publications

(95 citation statements)

References 32 publications

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“…Nonrheumatic valve diseases include the more common AS, 2 MAC, 3,5 and MVP 4,6 and less frequent disorders such as bicuspid aortic valve, 13,14 supravalvular AS, 15,16 and pulmonary valve stenosis. 17 Development of these diseases is suspected to have a genetic component.…”

Section: Discussion Valve Disease and Geneticsmentioning

confidence: 99%

“…1 Causes of valvular diseases include nonrheumatic diseases such as mitral valve prolapse (MVP), mitral annular calcification (MAC), and senile aortic sclerosis/stenosis (AS), [2][3][4][5][6] as well as rheumatic heart diseases (RHDs) that are usually considered secondary to infection. Although all of these conditions may lead to death, 2,5,6 they are often benign. 6 Nonrheumatic aortic and mitral valve diseases are suspected to result from pathophysiological processes containing genetic components.…”

mentioning

confidence: 99%

“…Although all of these conditions may lead to death, 2,5,6 they are often benign. 6 Nonrheumatic aortic and mitral valve diseases are suspected to result from pathophysiological processes containing genetic components. For example, MVP may have an autosomal dominant inheritance pattern with age-and sex-based variable expressivity.…”

mentioning

confidence: 99%

“…Although a genetic component is suggested [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17] and death is a known, albeit rare, complication, 2,5,6 it is unknown whether genetic factors contribute to death resulting from valve diseases. The present study used a genealogical, populationbased resource linked to death records to evaluate the familiality of death resulting from cardiac valve diseases.…”

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Evidence for a Heritable Component in Death Resulting From Aortic and Mitral Valve Diseases

et al. 2004

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Background-Cardiac valvular diseases contribute to Ͼ42 000 deaths yearly in the United States, but the role of genetics in these deaths is unknown. This study evaluated the familiality of death resulting from aortic, mitral, and all valvular diseases using a population-based genealogy linked to death records. Methods and Results-The Utah Population Database contains Ͼ2 million individual records with genealogy data and 250 000 linked death certificates. Nonrheumatic aortic (nϭ932), mitral (nϭ1165), and all valvular (nϭ2504) disease deaths and rheumatic heart disease deaths (nϭ4713) were studied. Familial relative risks (FRRs) were assessed for firstand second-degree relatives. Familiality was also evaluated with the genealogical index of familiality, which considers all relationships in the Utah Population Database. FRRs were increased only for mitral valve death in both first-degree (FRR, 2.55; PϽ0.0001) and second-degree (FRR, 1.67; PϽ0.0001) relatives. Genealogical index of familiality analysis showed significant excess relatedness for all groups (PϽ0.001). Genealogical index of familiality results (PϽ0.001) for early age at death cases showed higher mean relatedness, a common characteristic of heritable disorders. Excess familiality extended to distant relatives for mitral (second-degree relatives) and aortic (beyond second-degree relatives) valve death. Conclusions-Deaths resulting from nonrheumatic mitral and aortic diseases clustered among both close and distant relatives, especially among early age at death cases, suggesting a significant genetic component in death resulting from valvular diseases. Future studies should focus on gene discovery.

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Section: Discussion Valve Disease and Geneticsmentioning

confidence: 99%

mentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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Evidence for a Heritable Component in Death Resulting From Aortic and Mitral Valve Diseases

et al. 2004

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“…For example, mitral valve prolapse (MVP) and bicuspid aortic valve (BAV), considered among the most common congenital cardiomiopathies in the adult population (0.6% up to 2.4%, in the Framingham heart study, for MVP [33,34] and 0.5%-0.6% for BAV [35] ) remain often undiagnosed through PE and ECG. With this regard, it is known that these valvulopaties are frequently complicated by severe dysfunctions requiring cardio surgery [36][37][38] , that more than 50% of BAV evolve to root or proximal ascending aorta dilatation caused by wall vessel structural alterations, with possible spontaneous rupture and dissection [39,40] and that, occasionally, MVP and BAV are the only pathological findings at the autopsy of athletes death suddenly [2,41] . For these reasons, it has been proposed to implement standard PPS with echocardiography in order to allow a risk stratification as well as an adequate follow up and recommendations [42,43] .…”

Section: Ppsmentioning

confidence: 99%

Pre-participation screening for the prevention of sudden cardiac death in athletes

Borrione¹

2013

WJM

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Does This Patient Have an Abnormal Systolic Murmur?

Etchells

Bell²,

Robb³

1997

JAMA

131

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Our objective was to review the available evidence of the precision and accuracy of the clinical examination for abnormal systolic murmurs. We conducted a MEDLINE search, manually reviewed all reference lists, and contacted authors of published studies. Each study was independently reviewed by 2 observers and graded for methodologic quality. We found that most studies were conducted using cardiologist examiners. In the clinical setting, the reliability of detecting systolic murmurs was fair (kappa, 0.30-0.48). The most useful findings for ruling in aortic stenosis are a slow rate of rise of the carotid pulse (positive likelihood ratio, 2.8-130), mid to late peak intensity of the murmur (positive likelihood ratio, 8.0-101), and decreased intensity of the second heart sound (positive likelihood ratio, 3.1-50). The most useful finding for ruling out aortic stenosis is the absence of murmur radiation to the right carotid artery (negative likelihood ratio, 0.05-0.10). Smaller, lower-quality studies indicate that cardiologists can accurately rule in and rule out mitral regurgitation, tricuspid regurgitation, hypertrophic cardiomyopathy, and echocardiographic mitral valve prolapse. We conclude that the clinical examination by cardiologists is accurate for detecting various causes of abnormal systolic murmurs. Studies of the clinical examination by noncardiologists are needed.

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Natural history of mitral valve prolapse

Cited by 151 publications

References 32 publications

Evidence for a Heritable Component in Death Resulting From Aortic and Mitral Valve Diseases

Evidence for a Heritable Component in Death Resulting From Aortic and Mitral Valve Diseases

Pre-participation screening for the prevention of sudden cardiac death in athletes

Does This Patient Have an Abnormal Systolic Murmur?

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