Natural History of Low-Grade Squamous Intraepithelial Lesion

Natural history and clearance of HPV after treatment of precancerous cervical lesions

“…This progression rate of 14.5% seems high, given that Saw et al. 19 have observed a progression rate of 11% for CIN1 lesions over a follow‐up of 60 months, in a study on the natural history of CIN lesions without treatment. A possible explanation of the fact that our progression rate did not diminish with treatment is the use of a single‐freeze technique, according to national policy, whereas in other study protocols a double‐freeze technique has been used.…”

Ambiguities in the LAST Standardization Project?

“…Among women 30 years or older with cervical LSIL, 63.8% carry HR-HPV of which ''only'' 5.7% progress to CIN 2+ [5]. CIN 1 followed up for 5 years by colposcopy and/or cytology progressed in 11% over 5 years [6]. Ten percent of atypical squamous cells cannot exclude highgrade squamous intraepithelial lesion are in fact CIN 2+ on colposcopy-directed biopsy [7].…”