Natural History of <i>Helicobacter pylori</i> Infection in Childhood: Eight‐Year Follow‐Up Cohort Study in an Urban Community in Northeast of Brazil

Queiroz, Dulciene Maria Magalhães; Carneiro, Jéssica Gomes; Neto, Manuel B. Braga; Fialho, Andrea; Fialho, Andre; Gonçalves, Maria Helena; Rocha, Gifone Aguiar; Rocha, Andréia Maria Camargos; Braga, Lúcia Libanez Bessa Campelo

doi:10.1111/j.1523-5378.2011.00894.x

Cited by 34 publications

(30 citation statements)

References 24 publications

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“…As previously appointed by other Brazilian researches, 66% of our study population presented H. pylori's infection, among these patients, nearly 58% reported less than 9 years of study. This finding has been also observed in other studies and possibly indicates socioeconomic status and years of study as important conditions associated to the risk factors for H. pylori's transmission (9,33) . According to data previously reported (Kodaira et al), our findings support that H. pylori frequency is not related with smoking habit or alcohol consumption (20) .…”

Section: Discussionsupporting

confidence: 88%

“…H. pylori causes one of the most prevalent infections in human beings with a worldwide distribution that can reach relative frequencies that vary from 20% to 90% in different populations (33,35) . The microorganism exhibits a high tropism to the gastric epithelium, where can causes immune and inflammatory responses that may persist for all life if not eradicated (5,10) .…”

Section: Introductionmentioning

confidence: 99%

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Lack of Association Between Helicobacter Pylori's Virulence and Increased Serum C-Reactive Protein Levels in Functional Dyspeptic Patients

Andreolla

Bona

Sander

et al. 2016

Arq. Gastroenterol.

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-Background -Recently, a great variety of studies aimed to investigate and even suggest Helicobacter pylori as an important key factor in gastrointestinal and non-gastrointestinal events development. The well-established relationship between bacterial virulence and increased risk for peptic ulcer or gastric carcinoma is not so clear when comparing inflammation markers alterations, such C-reactive protein, with the pathogen. Objective -The objective of this study was to evaluate the presence of H. pylori, bacterial virulence and C-reactive protein serum levels in individuals diagnosed with functional dyspepsia. Methods -Were prospectively included in this study 489 dyspeptic individuals. They fulfill Rome III clinical criteria for the diagnosis of functional dyspepsia with no organic disease at endoscopy. The bacterial infection was established by histology and urease rapid test. The levels of serum C-reactive protein were obtained by immunonefelometry and CagA status of H. pylori positive individuals was determined through an imunoenzimatic assay. Results -Prevalence rate of H. pylori was 66.3% and virulence factor CagA was detected in nearly 43% of positive samples. In addition, it has been noticed an association between Ilex paraguariensis (yerba maté) consumption and pathogen's prevalence. An important effect of bacterial infection on inflammation was only observed in gastric epithelium. Conclusion -No systemic response to the pathogen, measured through C-reactive protein levels, was observed, regardless of CagA status. Otherwise, the intake of yerba maté should be considered as a cultural factor possibly related to H. pylori's transmission. According to the recent reports, CagA positive strains can cause severe damage to the gastric epithelium, being related specially with increased levels of interleukin-8 (IL-8), gastroduodenal ulcers and gastric neoplasia occurrence (26,29,41) . In addition, this virulence factor has been associated with systemic inflammation, resulting in high serum C-reactive protein (CRP) levels and the bacteria presence being related to higher cardiovascular risks (21,37) . Some behaviors have been associated to the transmission of H. pylori. Studies have reported that several aspects can be related to incidence and prevalence rates like socioeconomic status, years of study, institutionalization practice or social habits (8,20) . In 2010, a Brazilian study has demonstrated an anti-H. pylori activity of plant extracts, like yerba maté tea (Ilex paraguariensis), but no association between bacteria prevalence and tea consumption has been previously described (6) . Andreolla HF, Bona LR, Sander GB, Mazzoleni LE, Tavares RG, Prolla JC. Lack of association between Helicobacter pylori's virulence and increased serum C-reactive protein levels in functional dyspeptic patients HEADINGS - 50Arq Gastroenterol v. 53 no. 1 -jan./mar. 2016All H. pylori's infected people present histological gastritis. Moreover, the bacteria, classified as type I carcinogen (32) , has been associated with the...

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Section: Discussionsupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Lack of Association Between Helicobacter Pylori's Virulence and Increased Serum C-Reactive Protein Levels in Functional Dyspeptic Patients

Andreolla

Bona

Sander

et al. 2016

Arq. Gastroenterol.

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“…In populations with a higher SES, the risk of acquiring it also begins early, although more slowly, reaching significantly lower rates than those seen in populations with a low SES. Acquiring the infection during childhood may be decisive to the morbidity and mortality associated with chronic H pylori infection in the adult population (49,140,156,162) .…”

Section: Group 5 Epidemiology Of Infection and Proposals For Action mentioning

confidence: 99%

3rd BRAZILIAN CONSENSUS ON Helicobacter pylori

Coelho

Maguinilk

Zaterka³

et al. 2013

Arq. Gastroenterol.

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Significant progress has been obtained since the Second Brazilian Consensus Conference on Helicobacter pylori Infection held in 2004, in São Paulo, SP, Brazil, and justify a third meeting to establish updated guidelines on the current management of H. pylori infection. The Third Brazilian Consensus Conference on H pylori Infection was organized by the Brazilian Nucleus for the Study of Helicobacter, a Department of the Brazilian Federation of Gastroenterology and took place on April 12-15, 2011, in Bento Gonçalves, RS, Brazil. Thirty-one delegates coming from the five Brazilian regions and one international guest, including gastroenterologists, pathologists, epidemiologists, and pediatricians undertook the meeting. The participants were allocated in one of the five main topics of the meeting: H pylori, functional dyspepsia and diagnosis; H pylori and gastric cancer; H pylori and other associated disorders; H pylori treatment and retreatment; and, epidemiology of H pylori infection in Brazil. The results of each subgroup were submitted to a final consensus voting to all participants. Relevant data were presented, and the quality of evidence, strength of recommendation, and level of consensus were graded. Seventy per cent and more votes were considered as acceptance for the final statement. This article presents the main recommendations and conclusions to guide Brazilian doctors involved in the management of H pylori infection.

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“…elicobacter pylori infection is acquired primarily in early childhood and is predominantly transmitted within families, infected mother and siblings being the most common familial source of the microorganism (1)(2)(3)(4)(5). Infants and toddlers most frequently acquire and lose the infection (3,6), but there are substantial knowledge gaps in respect to the predictors of initial acquisition, as well as the persistence of the infection, in this age group.…”

mentioning

confidence: 99%

Helicobacter pylori Infection in Infants and Toddlers in South America: Concordance between [ ¹³ C]Urea Breath Test and Monoclonal H. pylori Stool Antigen Test

et al. 2013

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H elicobacter pylori infection is acquired primarily in early childhood and is predominantly transmitted within families, infected mother and siblings being the most common familial source of the microorganism (1-5). Infants and toddlers most frequently acquire and lose the infection (3, 6), but there are substantial knowledge gaps in respect to the predictors of initial acquisition, as well as the persistence of the infection, in this age group. In addition, in children, H. pylori infection has been associated with iron deficiency anemia, diarrheic disease, and impairment of growth, weight, and cognitive functions (7,8). Thus, a simple and reliable noninvasive test to detect H. pylori infection in this age group is required, especially in developing countries, where the prevalence of H. pylori infection is very high.The noninvasive [ 13 C]urea breath test ([ 13 C]UBT) (9-12) and stool antigen test (13-15) are very reliable for the diagnosis of H. pylori infection in children older than 6 years. The stool test based on monoclonal antibodies has proved to be highly accurate in all age groups (13-15), but the specificity of the [ 13 C]UBT varies from 82% to 100% for young children (9-12). However, studies of this subject are scarce and have not included large enough numbers of infants and toddlers to obtain reliable results. Furthermore, different "gold standard" tests have been used to validate the [ 13 C]UBT, and most studies are in developed countries, where the prevalence of infection is very low (11,12,16,17).To validate noninvasive tests for diagnosis of H. pylori infection, the indicated "gold standard" includes at least two invasive tests, which is a difficult task with young children due to the current rarity of symptomatic H. pylori infection in this period of life. In addition, as stated by Goodman and Correa, validation using invasive tests has some limitations; recent short-term colonization and patchy distribution of the bacterium in the gastric mucosa may decrease the sensitive of biopsy-based tests in very young children (18). Such problems currently restrict epidemiological investigations of the acquisition of H. pylori infection in infants and toddlers in developing-country settings.The aim of this study was to investigate whether the two independent noninvasive tests for H. pylori infection diagnosis, the [ 13 C]UBT and monoclonal stool antigen test, have good concordance in young children. For that, we evaluated a cohort of infants and toddlers living in impoverished regions of two developing countries in South America. Our hypothesis was that if the [ 13 C]UBT and monoclonal stool antigen test had good agreement in infants and toddlers, either of the two noninvasive tests could be used for the diagnosis of H. pylori in this age group. We also aimed to investigate causes linked to discordant results between the two tests.

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Natural History of Helicobacter pylori Infection in Childhood: Eight‐Year Follow‐Up Cohort Study in an Urban Community in Northeast of Brazil

Abstract: Factors linked to remain and to gain H. pylori infection in a poor region were increased number of children in the household and the male gender. Also, the acquisition rates were higher than the loss rates, which lead to an increase in the infection prevalence with age.

Cited by 34 publications

References 24 publications

Lack of Association Between Helicobacter Pylori's Virulence and Increased Serum C-Reactive Protein Levels in Functional Dyspeptic Patients

Lack of Association Between Helicobacter Pylori's Virulence and Increased Serum C-Reactive Protein Levels in Functional Dyspeptic Patients

3rd BRAZILIAN CONSENSUS ON Helicobacter pylori

Helicobacter pylori Infection in Infants and Toddlers in South America: Concordance between [ ¹³ C]Urea Breath Test and Monoclonal H. pylori Stool Antigen Test

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Natural History of Helicobacter pylori Infection in Childhood: Eight‐Year Follow‐Up Cohort Study in an Urban Community in Northeast of Brazil

Abstract: Factors linked to remain and to gain H. pylori infection in a poor region were increased number of children in the household and the male gender. Also, the acquisition rates were higher than the loss rates, which lead to an increase in the infection prevalence with age.

Cited by 34 publications

References 24 publications

Lack of Association Between Helicobacter Pylori's Virulence and Increased Serum C-Reactive Protein Levels in Functional Dyspeptic Patients

Lack of Association Between Helicobacter Pylori's Virulence and Increased Serum C-Reactive Protein Levels in Functional Dyspeptic Patients

3rd BRAZILIAN CONSENSUS ON Helicobacter pylori

Helicobacter pylori Infection in Infants and Toddlers in South America: Concordance between [ 13 C]Urea Breath Test and Monoclonal H. pylori Stool Antigen Test

Contact Info

Product

Resources

About

Helicobacter pylori Infection in Infants and Toddlers in South America: Concordance between [ ¹³ C]Urea Breath Test and Monoclonal H. pylori Stool Antigen Test