Natural History of Hepatitis C

Lingala, Shilpa; Ghany, Marc G.

doi:10.1016/j.gtc.2015.07.003

Cited by 217 publications

(199 citation statements)

References 131 publications

(114 reference statements)

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“…3, 4 At a global level, around 71 million people have HCV, with approximately 399,000 deaths annually. 5 In Brazil, the data show that the numbers of deaths due to HCV have been increasing over time in all regions.…”

Section: Introductionmentioning

confidence: 99%

“…A cross-sectional study pliers, tattooing with non-sterile material, unprotected sexual intercourse and use of needles shared among drug users. [2][3][4][5][6] HCV infection and other forms of viral hepatitis are diseases that have an impact on public health worldwide. Although many data suggest that HCV infection could be eliminated over the next 15-20 years, good understanding of HCV infections is still required in order to develop strategies for preventing new infections.…”

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confidence: 99%

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Hepatitis C: evaluation of outcomes and georeferencing of cases in Santa Cruz do Sul, Brazil, between 2002 and 2015. A cross-sectional study

et al. 2017

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Section: Introductionmentioning

confidence: 99%

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confidence: 99%

Hepatitis C: evaluation of outcomes and georeferencing of cases in Santa Cruz do Sul, Brazil, between 2002 and 2015. A cross-sectional study

et al. 2017

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“…Hepatitis C virus (HCV) infection is a serious public health problem and the main cause of chronic hepatic disease, cirrhosis, hepatocarcinoma, and liver transplant (LINGALA; GHANY, 2015). The chronic disease is associated with impairments in health-related quality of life (SOUZA et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

A cross sectional study regarding HCV patients’ knowledge about viral transmission and attitudes regarding toothbrush care

Garbín¹,

Souza²,

Moimaz³

et al. 2017

Biosci. J.

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Hepatitis C virus (HCV) is transmitted mainly by parenteral route, although, some studies have pointed the potential of transmission by sharing infected instruments, like toothbrushes. The aim of this study was to investigate the knowledge about viral transmission among HCV infected individuals and attitudes regarding toothbrush care. A cross-sectional study was conducted among 112 HCV-infected individuals from Uberlandia City, Minas Gerais State (Southeast Brazil). Data were collected through a questionnaire containing demographic data and other questions (correct responses were given one point, incorrect and uncertain responses were given zero point) about knowledge of HCV transmission (6 items in total; scores lower than 4 points indicated poor knowledge level and scores equal or higher than 4 indicated good knowledge level); attitudes regarding toothbrush care (7 items; scores 0 to 3 indicated inadequate attitudes, and scores higher than 3 indicated adequate attitudes). The statistical analysis included Chi-square test, Exact Fisher's test and Maximum Likelihood Estimation (p < 0.05 was considered significant). Out of the 112 questionnaires distributed, 85 (response rate: 75.9%) were included. Most individuals were male (60%), Caucasian (69.4%), aged more than 51 years (51.7%), had attended pre-school (35.1%), and had incomes up to $525.2 per month (49.4%). Fifty four percent of individuals showed good Knowledge level of HCV transmission; 43.5% did not identify HCV transmission through toothbrushes and 80% did not believe in HCV transmission by saliva. A significant association were observed between Knowledge level of HCV and age (p= 0.020); and education level (p= 0.000). Forty-five HCV-infected individuals (64.70%) had adequate attitudes regarding toothbrushes care. Significant associations were observed between toothbrush care level and: age (p= 0.005); education level (p= 0.000); and family income (p= 0.038). HCV-infected individuals showed good knowledge level about main aspects of HCV infection and adequate attitudes regarding toothbrush care.

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“…La progresión de la fibrosis se ve acelerada en hombres, en personas mayores de 50 años, en consumidores de alcohol, y en coinfectados por el virus de la inmunodeficiencia humana (VIH) o por el virus de la hepatitis B 1 . Aproximadamente un 15-30% de estos pacientes, tras 20-30 años, desarrollan cirrosis con un riesgo anual de carcinoma hepatocelular del 1-4% 2 .…”

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“…Aproximadamente un 15-30% de estos pacientes, tras 20-30 años, desarrollan cirrosis con un riesgo anual de carcinoma hepatocelular del 1-4% 2 . La infección crónica por el VHC es la principal causa de enfermedad hepática crónica y de indicación de trasplante hepático en Europa Occidental y América del Norte 1,3 . En España se estima una prevalencia en torno a 472.000 afectados 4 , aunque dicha cifra se basa en estudios seroepidemiológicos antiguos.…”

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Effectiveness of second-generation direct-acting antivirals in chronic hepatitis C

Juanbeltz

Zozaya

Repáraz

et al. 2017

An Sist Sanit Navar

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Fundamento. Los antivirales de acción directa de segunda generación (AAD) han demostrado porcentajes elevados de respuesta viral sostenida (RVS) en el tratamiento de la hepatitis C crónica en ensayos clínicos. Este estudio tiene como objetivo estimar la efectividad de los AAD en el tratamiento de esta enfermedad. Material y métodos.Se estudiaron pacientes monoinfectados por el virus de la hepatitis C (VHC) y coinfectados por VHC y virus de la inmunodeficiencia humana (VIH) que iniciaron tratamientos libres de interferón con AAD durante 2015. La RVS se definió como una carga viral indetectable a las 12 semanas de finalizar el tratamiento, y fue el indicador principal de efectividad.resultados. Se incluyeron 293 pacientes, 52 (17,7%) coinfectados por VIH. Los genotipos VHC más prevalentes fueron el 1b en monoinfectados (41,5%) y 1a en coinfectados (40,4%). La proporción de cirróticos fue superior en la población coinfectada (69,2% vs 41,1%; p<0,0001), en su mayoría ChildPugh A. La cifra global de RVS fue del 96,9% (284/293) en un análisis por intención de tratar (IC 95%: 94,9-98,9), siendo 4 los pacientes con fracaso virológico. Tanto pacientes naïve como pretratados tuvieron RVS superior al 95%, y en la mayoría de subgrupos establecidos según la presencia o no de cirrosis, la coinfección VIH y el genotipo, la efectividad se situó próxima o por encima del 90%.conclusiones. Los AAD presentan una efectividad elevada, igual o superior a la descrita en los ensayos clínicos, e incluso en subpoblaciones difíciles de tratar.Palabras clave: Hepatitis C crónica. VIH. Agentes antivirales. Efectividad terapéutica. Práctica clínica. abstract background. Second-generation direct-acting antivirals (DAA) have shown high sustained virologic response (SVR) for the treatment of chronic hepatitis C in clinical trials. The objective of this study is to estimate DAA effectiveness in treatment of this disease. Methods. Hepatitis C virus (HCV) monoinfected patients and HCV-human immunodeficiency virus (HIV) coinfectedpatients who started interferon-free DAA based regimens during 2015 were included. The primary effectiveness outcome was SVR, defined as an undetectable viral load 12 weeks after the end of treatment. results.A total of 293 patients were enrolled, and 52 (17.7%) were HIV coinfected. HCV 1b genotype was the most prevalent in monoinfected patients (41.5%) and 1a in HIV coinfected patients (40.4%). The proportion of cirrhosis was higher among HIV coinfected patients (69.2% vs 41.1%; p<0.0001), mostly Child-Pugh A. SVR was achieved by 96.9% of patients (284/293), in an intention-to-treat analysis (CI 95%: 94.9-98.9), in which just 4 people had virologic failure. Both naïve and pretreated patients had SVR higher than 95%, and in most of subgroups, according to the presence of cirrhosis, HIV coinfection and HVC genotype, effectiveness rates were near or above 90%.conclusions. DAA are highly effective, with similar or higher rates of SVR than that found in clinical trials, and even among difficult to treat populations. Keywords

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Natural History of Hepatitis C

Cited by 217 publications

References 131 publications

Hepatitis C: evaluation of outcomes and georeferencing of cases in Santa Cruz do Sul, Brazil, between 2002 and 2015. A cross-sectional study

Hepatitis C: evaluation of outcomes and georeferencing of cases in Santa Cruz do Sul, Brazil, between 2002 and 2015. A cross-sectional study

A cross sectional study regarding HCV patients’ knowledge about viral transmission and attitudes regarding toothbrush care

Effectiveness of second-generation direct-acting antivirals in chronic hepatitis C

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