Natural History of Genital Papillomavirus Infections

Schneider, Achim

doi:10.1159/000150378

Cited by 31 publications

(20 citation statements)

References 92 publications

(106 reference statements)

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“…46 Further study is indicated into the correlation between female genital HPV types and HPV types in patients with lung cancer. 47 …”

Section: Discussionmentioning

confidence: 99%

Recent striking changes in histological differentiation and rate of human papillomavirus infection in squamous cell carcinoma of the lung in Okinawa, a subtropical island in southern Japan

Miyagi

2000

Journal of Clinical Pathology

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Aims-The incidence of lung cancer in Okinawa has been the highest in Japan since 1975, and squamous cell carcinoma (SCC), especially the well diVerentiated form, is the most prevalent form in Okinawa, although well diVerentiated SCC is relatively rare in mainland Japan. Furthermore, a high proportion of SCC of the lung in Okinawa was positive for human papillomavirus (HPV). In this study, we report recent striking changes in histological features and in the incidence of HPV infection. Methods-In Okinawa between 1986 and 1998, 1109 surgically resected lung tumours were examined histopathologically. In addition, human papillomavirus infection was detected by the polymerase chain reaction and Southern blot analysis in SCC cases reported in 1993 and 1995-8. Non-isotopic in situ hybridisation of HPV DNA was also carried out. Results-Up until 1994 SCC, especially the well diVerentiated form, was the most prevalent type of tumour. However, since 1995 the number of such cases has diminished steadily, accompanied by a slight rise in the incidence of adenocarcinoma. Although most present and past patients are heavy smokers, the incidence of SCC, especially the well diVerentiated form, continues to decrease steadily. Furthermore, in 1993, HPV was detected in 79% of all cases, and was particularly prevalent in the well diVerentiated form, but the rate fell to 68% in 1995, 35% in 1996, 23% in 1997, and 24% in 1998. The age distribution of patients, the male to female ratio, and the number of tumours overexpressing p53 protein did not change significantly over the study period, and thus did not correlate with changes in the diVerentiation of SCC. Conclusions-The decreasing incidence of viral infection correlates strongly with the falling numbers of SCC cases, especially well diVerentiated cases. These findings suggest that HPV might be involved in the development of SCC of the lung, aVecting the histological diVerentiation of SCC in particular, at least in Okinawa, a subtropical island in southern Japan. (J Clin Pathol 2000;53:676-684) Keywords: squamous cell carcinoma of the lung; histological diVerentiation; human papillomavirus Lung cancer increased 40-fold and 36-fold in Japanese men and women, respectively, between 1950 and 1997.

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“…46 Further study is indicated into the correlation between female genital HPV types and HPV types in patients with lung cancer. 47 …”

Section: Discussionmentioning

confidence: 99%

Recent striking changes in histological differentiation and rate of human papillomavirus infection in squamous cell carcinoma of the lung in Okinawa, a subtropical island in southern Japan

Miyagi

2000

Journal of Clinical Pathology

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“…20 The properties of the HPV E6 and E7 oncoproteins have been reviewed extensively. [36][37][38][39] E6 Proteins are localized in the nuclear matrix and other nonnuclear membranes and can immortalize primary human keratinocytes in conjunction with E7. The HPV16 E6 oncoprotein contains zinc-binding motifs and can complex with the host cell p53 tumor suppresser protein, thereby inducing p53 degradation.…”

Section: Genome Organizationmentioning

confidence: 99%

“…In situ hybridization is labor-intensive and cannot be reliably performed under low stringency as it allows for cross-hybridizations with cellular sequences and cannot distinguish false positives. 37,107,124 …”

Section: Hybridization Techniquesmentioning

confidence: 99%

Human Papillomavirus and head and neck cancer: Epidemiology and molecular biology

1998

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“…Some of the 75 virus types are specific for epithelia of the lower anogenital and upper respiratory tracts. The highly homologous HPV-6 and HPV-11 typically cause condylomata or papillomas with little risk of neoplastic progression, whereas a small percentage of the infections by HPV-16, HPV-18, and related types can progress to high grade dysplasias and carcinomas (for review, see Schneider 1994). Propagation of both high-risk and low-risk HPV types is tightly linked to squamous epithelial differentiation in patient specimens Stoler et al 1989Stoler et al , 1992.…”

mentioning

confidence: 99%

Differentiation-dependent up-regulation of the human papillomavirus E7 gene reactivates cellular DNA replication in suprabasal differentiated keratinocytes.

Cheng¹,

Schmidt-Grimminger²,

Murant³

et al. 1995

Genes Dev.

305

284

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Natural History of Genital Papillomavirus Infections

Cited by 31 publications

References 92 publications

Recent striking changes in histological differentiation and rate of human papillomavirus infection in squamous cell carcinoma of the lung in Okinawa, a subtropical island in southern Japan

Recent striking changes in histological differentiation and rate of human papillomavirus infection in squamous cell carcinoma of the lung in Okinawa, a subtropical island in southern Japan

Human Papillomavirus and head and neck cancer: Epidemiology and molecular biology

Differentiation-dependent up-regulation of the human papillomavirus E7 gene reactivates cellular DNA replication in suprabasal differentiated keratinocytes.

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