Natural History of Eosinophilic Gastroenteritis

Chambrun, Guillaume Pineton de; Gonzalez, Florent; Canva, Jean-Yves; Gonzalez, S.; Houssin, L.; Desreumaux, Pierre; Cortot, Antoine; Colombel, Jean–Frédéric

doi:10.1016/j.cgh.2011.07.017

Cited by 178 publications

(175 citation statements)

References 10 publications

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“…Talley et al [4] reported a proportion of mucosal, muscular and subserosal disease of 57.5, 30 and 12.5%, respectively [4]. In our experience, there was a predominance of mucosal forms (44%) with a higher proportion of subserosal forms (49%) and few muscular diseases (12%) [20]. Variation in the proportion of anatomical patterns in eosinophilic enteritis may be due to limitation in the evaluation of the depth of infiltration in patients without surgical resection.…”

Section: Clinical Characteristics Of Patients With Eosinophilic Entermentioning

confidence: 86%

“…Since its first description by Kaiser in 1937, less than 400 cases have been reported in the literature, either in the form of clinical cases or in single-center retrospective series [1,4,16,17,18,19,20,21]. Its prevalence is estimated to be 1 per 100,000 population [4].…”

Section: Epidemiology Of Eosinophilic Enteritismentioning

confidence: 99%

“…The main inaugural symptoms are abdominal pain, nausea and/or vomiting, diarrhea and ascites [4,20,21]. Other gastrointestinal symptoms may be indicative such as dysphagia, rectal bleeding or jaundice.…”

Section: Clinical Characteristics Of Patients With Eosinophilic Entermentioning

confidence: 99%

“…Also, the time between first symptoms and diagnosis may be long, with more than 2 years of delay in some case series. Eosinophilic enteritis can affect all age groups, with a peak incidence between the third and fourth decades, and presents a male predominance [4,20]. …”

Section: Epidemiology Of Eosinophilic Enteritismentioning

confidence: 99%

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Eosinophilic Enteritis

Chambrun¹,

Desreumaux

Cortot

2015

Dig Dis

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Background: Eosinophilic enteritis, also known as eosinophilic gastroenteritis, is a rare primary eosinophilic gastrointestinal disorder (EGID) of unknown etiology characterized by the presence of an intense eosinophilic infiltrate on histopathology of the intestinal mucosa. Key Messages: The etiology of eosinophilic enteritis remains obscure. There is growing evidence to support the role of aeroallergens and food allergens in the pathogenesis of this disorder as children and adults with EGIDs often have positive skin testing for food allergens and a familial history of allergic diseases. Moreover, significant progress has been made in elucidating that EGIDs involve mechanisms that fall between pure IgE-mediated and delayed Th2 type responses. Preclinical studies have identified a contributory role for the cytokine IL-5 and eotaxin chemokines, providing a rationale for specific disease therapy. Eosinophilic enteritis causes a wide array of gastrointestinal symptoms such as abdominal pain, diarrhea, nausea, vomiting, bloating or ascites, and its diagnosis requires a high degree of clinical likelihood given the nonspecific presentation and physical examination findings. The Klein classification arbitrarily divided patients with eosinophilic enteritis into those with predominantly mucosal, muscle layer or subserosal disease relying on the concept that clinical presentation is dependent on the predominant involved layer of the gastrointestinal tract. Main therapeutic options are represented by oral corticosteroids for a short period with good efficacy. Antihistaminic drugs and sodium cromoglycate have also been used to treat patients with eosinophilic enteritis. Conclusion: Eosinophilic enteritis is generally considered as a benign disease with no relapse, but half of the patients may present a more complex natural history characterized by unpredictable relapses and a chronic course.

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Section: Clinical Characteristics Of Patients With Eosinophilic Entermentioning

confidence: 86%

Section: Epidemiology Of Eosinophilic Enteritismentioning

confidence: 99%

Section: Clinical Characteristics Of Patients With Eosinophilic Entermentioning

confidence: 99%

Section: Epidemiology Of Eosinophilic Enteritismentioning

confidence: 99%

See 2 more Smart Citations

Eosinophilic Enteritis

Chambrun¹,

Desreumaux

Cortot

2015

Dig Dis

Self Cite

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“…15 While many drugs have been used as steroid savers, including azathioprine, sodium cromoglycate and montelukast. 16,17 Sodium cromoglycate is a stabilizer that prevents the release of toxic mediators from mast cells, and reduces the absorption of antigens from the small intestine. It has been proven effective and safe in some cases of EGE at a dose of 200 mg 3-4 times /day.…”

Section: Treatment Varieties Of Egementioning

confidence: 99%

Eosinophilic Gastroenteritis Presenting With Ascites; Case Report and Review of Literature

Elsadek¹

2014

Zagazig University Medical Journal

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Eosinophilic gastroenteritis (EGE) is an uncommon disorder affecting both children and adults, that is characterized by eosinophilic infiltration of the stomach and intestine with or without peripheral blood eosinophilia, in the absence of other known causes of eosinophilia. Presentation may vary depending on the location as well as on the depth and extent of involvement and usually runs a chronic relapsing course. Eosinophilic ascites (EA) is probably the most unusual and rare presentation of EGE. Almost all reported cases of EA are idiopathic. One case of EGE presenting with EA, that was successfully diagnosed and treated, is reported here. The subsequent review describes the main features and management of EGE and EA.

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Gastritis and Gastropathy

Washington

Peek

2015

Yamada' S Textbook of Gastroenterology

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Natural History of Eosinophilic Gastroenteritis

Cited by 178 publications

References 10 publications

Eosinophilic Enteritis

Eosinophilic Enteritis

Eosinophilic Gastroenteritis Presenting With Ascites; Case Report and Review of Literature

Gastritis and Gastropathy

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