Natural History of Elderly-onset Ulcerative Colitis: Results from a Territory-wide Inflammatory Bowel Disease Registry

Abstract

Elderly-onset UC patients are increasing in number. These patients have higher risk of opportunistic infections, hospitalisation, colorectal cancer, and mortality than non-elderly-onset patients. Management and therapeutic strategies in this special group need careful attention.

The potential of volatile organic compounds for the detection of active disease in patients with ulcerative colitis

“…It is also increasingly recognised as secondary infection increasing the risk of more severe disease course and colectomy . In addition, with the increasing incidence of elderly onset UC, the incidence of colonic diverticulitis will also increase in the UC population . The VOC analyses and statistical model used in the present study, did show that the discriminating VOCs could also distinguish between UC inflammation and non‐UC related colonic inflammation.…”

Infection‐related hospitalizations in the first year after inflammatory bowel disease diagnosis

“…Particular care should be taken when dealing with infection in this subgroup of high‐risk IBD patients. In our recent study we also found that elderly‐onset UC patients had a higher risk of developing CMV and C . difficile infections, despite comparable exposure to corticosteroids and immunosuppressive agents.…”

“…We identified all patients newly diagnosed with IBD between January 2010 and December 2012 in the Hong Kong IBD Registry. The details of the registry had been reported previously . Briefly, it is a territory‐wide IBD registry including 13 regional hospitals of the Hospital Authority of Hong Kong SAR, China, the sole public healthcare provider for 7.2 million local residents.…”

“…Baseline clinical information of the enrolled IBD patients was individually entered into the registry database, which included age at onset, disease characteristics and phenotypes, treatment received, smoking status, personal medical history and family history of IBD . The disease phenotypes were classified according to the Montreal classification .…”

The Same Intestinal Inflammatory Disease despite Different Genetic Risk Factors in the East and West?

“…Furthermore, a territory-wide study in the Chinese population showed that elderly-onset UC patients are increasing and they have a higher risk of opportunistic infections, hospitalisation, colorectal cancer (CRC), and mortality than non-elderly-onset patients. Therefore, management and therapeutic strategies in this special group need special attention [45]. …”