Natural History of Brain Lesions in Extremely Preterm Infants Studied With Serial Magnetic Resonance Imaging From Birth and Neurodevelopmental Assessment

Dyet, Leigh; Kennea, Nigel; Counsell, Serena J.; Maalouf, Elia F.; Ajayi-Obe, Morenike; Duggan, Philip; Harrison, Michael; Allsop, Joanna; Hajnal, Joseph V.; Herlihy, Amy H.; Edwards, Bridget; Laroche, Sabrina; Cowan, Frances; Rutherford, Mary A.; Edwards, A. David

doi:10.1542/peds.2005-1866

Cited by 425 publications

(376 citation statements)

References 37 publications

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“…Perinatal white matter injury (PWMI), also known as periventricular leukomalacia (PVL), is the predominant form of brain injury leading to such neuropsychiatric problems (Efron et al, 2003). Neonatal magnetic resonance imaging (MRI) studies have shown that 70% to 80% of all extremely premature infants develop white matter lesions (Dyet et al, 2006;Woodward et al, 2006). Furthermore, there is a direct relationship between MRI evidence of white matter injury and clinical severity of motor and cognitive impairment (Woodward et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

In vivo Magnetization Transfer MRI Shows Dysmyelination in an Ischemic Mouse Model of Periventricular Leukomalacia

Fatemi

Wilson

Phillips

et al. 2011

J Cereb Blood Flow Metab

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Periventricular leukomalacia, PVL, is the leading cause of cerebral palsy in prematurely born infants, and therefore more effective interventions are required. The objective of this study was to develop an ischemic injury model of PVL in mice and to determine the feasibility of in vivo magnetization transfer (MT) magnetic resonance imaging (MRI) as a potential monitoring tool for the evaluation of disease severity and experimental therapeutics. Neonatal CD-1 mice underwent unilateral carotid artery ligation on postnatal day 5 (P5); at P60, in vivo T2-weighted (T2w) and MT-MRI were performed and correlated with postmortem histopathology. In vivo T2w MRI showed thinning of the right corpus callosum, but no significant changes in hippocampal and hemispheric volumes. Magnetization transfer MRI revealed significant white matter abnormalities in the bilateral corpus callosum and internal capsule. These quantitative MT-MRI changes correlated highly with postmortem findings of reduced myelin basic protein in bilateral white matter tracts. Ventriculomegaly and persistent astrogliosis were observed on the ligated side, along with evidence of axonopathy and fewer oligodendrocytes in the corpus callosum. We present an ischemia-induced mouse model of PVL, which has pathologic abnormalities resembling autopsy reports in infants with PVL. We further validate in vivo MRI techniques as quantitative monitoring tools that highly correlate with postmortem histopathology.

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Section: Introductionmentioning

confidence: 99%

In vivo Magnetization Transfer MRI Shows Dysmyelination in an Ischemic Mouse Model of Periventricular Leukomalacia

Fatemi

Wilson

Phillips

et al. 2011

J Cereb Blood Flow Metab

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“…MRI has become the modality of choice for investigating normal brain maturation as well as neonatal brain injury and developmental neurological disorders because of the modality's superior soft-tissue contrast, good spatial resolution and various physical parameters that can be used as contrast mechanisms [1][2][3][4][5][6][7][8][9][10][11][12]. The development of MR-compatible incubators and dedicated neonatal imaging coils has further enabled safe and fast acquisition of high-resolution anatomical and functional imaging of the neonatal brain with greater signal-to-noise ratio (SNR) [12].…”

Section: Introductionmentioning

confidence: 99%

“…T 1 -W and T 2 -W images are used routinely for monitoring development and identifying pathologies in the neonatal brain [2,[4][5][6][7][8][9][10][11][12][13][14]18]. These images are also used for segmentation and quantitative morphometric measurements in the developing brain [14,17,[30][31][32][33][34][35][36][37].…”

Section: Introductionmentioning

confidence: 99%

“…Frequently, however, sequences used for clinical diagnosis and morphometric measurements are acquired using different imaging protocols and experimental settings. While clinical scanning often involves spin-echo (SE) T 1 -W and T 2 -W sequences, having limited spatial resolution in one of the imaging directions [6,[9][10][11]18], isotropic high-resolution imaging is increasingly used for morphometric studies [7,11,31,34]. Developing appropriate sequences is almost always a trade-off between increasing scan time to improve scan quality and risking image degradation caused by patient movement.…”

Section: Introductionmentioning

confidence: 99%

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Optimized T1- and T2-weighted volumetric brain imaging as a diagnostic tool in very preterm neonates

et al. 2010

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Background T1-and T 2 -W MR sequences used for obtaining diagnostic information and morphometric measurements in the neonatal brain are frequently acquired using different imaging protocols. Optimizing one protocol for obtaining both kinds of information is valuable. Objective To determine whether high-resolution T1-and T 2 -W volumetric sequences optimized for preterm brain imaging could provide both diagnostic and morphometric value. Materials and methods Thirty preterm neonates born between 24 and 32 weeks' gestational age were scanned during the first 2 weeks after birth. T1-and T 2 -W highresolution sequences were optimized in terms of signal-tonoise ratio, contrast-to-noise ratio and scan time and compared to conventional spin-echo-based sequences. Results No differences were found between conventional and high-resolution T 1 -W sequences for diagnostic confidence, image quality and motion artifacts. A preference for conventional over high-resolution T 2 -W sequences for image quality was observed. High-resolution T1 images provided better delineation of thalamic myelination and the superior temporal sulcus. No differences were found for detection of myelination and sulcation using conventional and high-resolution T 2 -W images. Conclusion High-resolution T1-and T 2 -W volumetric sequences can be used in clinical MRI in the very preterm brain to provide both diagnostic and morphometric information.R. Nossin-Manor (*)

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“…However, neurodevelopmental problems are frequently encountered in infants with normal cranial ultrasonography (US) (5). Compared with US, conventional magnetic resonance imaging (MRI) provides more information on white matter (WM) (6), and moderate to severe WM injury predicts adverse neurodevelopmental outcome (7)(8)(9)(10). However, neurodevelopmental problems also occur in preterm infants with normal MRI (10,11).…”

mentioning

confidence: 99%

Cortical somatosensory processing measured by magnetoencephalography predicts neurodevelopment in extremely low-gestational-age infants

et al. 2013

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Natural History of Brain Lesions in Extremely Preterm Infants Studied With Serial Magnetic Resonance Imaging From Birth and Neurodevelopmental Assessment

Abstract: Diffuse white matter abnormalities and post-hemorrhagic ventricular dilation are common at term and seem to correlate with reduced developmental quotients. Early lesions, except for cerebellar hemorrhage and major destructive lesions, do not show clear relationships with outcomes.

Cited by 425 publications

References 37 publications

In vivo Magnetization Transfer MRI Shows Dysmyelination in an Ischemic Mouse Model of Periventricular Leukomalacia

In vivo Magnetization Transfer MRI Shows Dysmyelination in an Ischemic Mouse Model of Periventricular Leukomalacia

Optimized T1- and T2-weighted volumetric brain imaging as a diagnostic tool in very preterm neonates

Cortical somatosensory processing measured by magnetoencephalography predicts neurodevelopment in extremely low-gestational-age infants

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