Natural history of advanced hepatocellular carcinoma in Crete. Association with hepatitis C virus

Skordilis, Panagiotis; Moschandrea, J.; Alexandrakis, Georgios; Charoulakis, N.; Tzardi, Maria; Manousos, O. N.

doi:10.1097/00042737-199710000-00011

Cited by 15 publications

(13 citation statements)

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“…This observation is in accord with the Japanese experience where HBV-related cancer has a reduced 3-year survival rate compared to HCV-related disease [19]. In our study albumin concentration was inversely related to mortality with an 11% decrease in the hazard rate for each unit increase of this protein [16]. The natural history of liver metastatic endocrine tumors is less well known.…”

Section: Natural Historysupporting

confidence: 92%

“…Survival in cases of hepatocellular carcinoma is strongly related to the Okuda classification [15]. In a recent study in Crete, a median survival of 16, 7 and 2 months for Okuda stage I, II and III liver tumors, respectively, was observed for patients who did not receive any therapy [16]. These findings are in agreement with earlier studies [17,18].…”

Section: Natural Historysupporting

confidence: 87%

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Octreotide for Cancer of the Liver and Biliary Tree

Kouroumalis¹

2001

Chemotherapy

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Inoperable liver tumors have an unfavorable natural course despite various therapeutic modalities. Octreotide, a somatostatin analog, has shown considerable antitumor activity on animal models of various hepatic tumors and on isolated cell culture lines. In this paper, a review of the experimental evidence is presented. Moreover clinical papers of case reports of uncontrolled studies of patients are also reviewed. The majority of clinical studies provide evidence of a clinical and biochemical response of liver endocrine tumors while regression of tumor size is a rare event. A randomized controlled trial of octreotide in the treatment of advanced hepatocellular carcinoma has shown a significant survival benefit in the treated patients. Literature reports indicate a stimulatory effect of octreotide on Kupffer cells as a possible antitumor mechanism, but other antiproliferative actions of octreotide have been suggested but not proved. Finally the question of the presence and affinity of somatostatin receptors on liver tumor tissue is discussed. In conclusion, according to our experience, octreotide administration is the best available treatment for advanced inoperable hepatocellular carcinoma and future better patient selection, based on receptor subtypes, might further improve the results.

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Section: Natural Historysupporting

confidence: 92%

Section: Natural Historysupporting

confidence: 87%

Octreotide for Cancer of the Liver and Biliary Tree

Kouroumalis¹

2001

Chemotherapy

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“…Moreover pockets of very high prevalence of anti-HCV have been discovered in the Rethymnon area [11]. These results are also in accordance with the higher prevalence of hepatocellular carcinoma due to HCV in the Rethymnon area [6]. …”

Section: Resultssupporting

confidence: 56%

“…This allows for epidemiological studies to be conducted with accuracy. Clinical studies have emphasized many differences between the island and mainland Greece, in both liver cell carcinoma characteristics and prevalence of viral markers [6]. A recent study in blood donors in northwest Greece reported an HBsAg prevalence of 0.85% [7] while a study of blood donors in Crete has shown a significantly lower prevalence of 0.40% for the same viral marker [8].…”

Section: Introductionmentioning

confidence: 99%

Prevalence of hepatitis B and C markers in high-risk hospitalised patients in Crete: a five-year observational study

et al. 2001

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“…Data stored in the computerized medical records-based system of the Gastroenterology Department of the University Hospital revealed that the main cause of liver disease was viral hepatitis C and B (Kouroumalis EA, Koulentaki M, unpublished observations). On the other hand, clinical studies have emphasized many differences between the island and mainland Greece, in both the prevalence of liver cell carcinoma and prevalence of viral markers [4]. A recent study of mortality rates caused by malignant neoplasms has shown that liver cancer is the fifth most common cancer in Crete, indicating a large difference compared with the national figure [5].We therefore examined the prevalence of hepatitis B and C markers in blood donors of three out of four blood banks in the three out of four prefectures of Crete, during a 5-year period, in an attempt to assess the prevalence and the geographical distribution of viral hepatitis B and C.…”

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confidence: 99%

Prevalence of hepatitis B and C markers in volunteer blood donors in Crete. A 5‐year study

Koulentaki¹,

Spanoudakis²,

Kantidaki

et al. 1999

Journal of Viral Hepatitis

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Greece is a country with an intermediate prevalence of hepatitis B virus (HBV) and hepatitis C virus (HCV) infection. Crete, the third-largest island of the Mediterranean sea, has a different prevalence of viral hepatitis. One-eighth of the total island population, of 550,000, was included in a 5-year study of blood donors from three out of four blood banks, serving three out of four prefectures of the island. Markers for HBV and HCV were studied and evaluated according to geographical area, gender and age of donor. A total of 65219 blood donors were studied. A greater number of males than females were hepatitis B surface antigen (HBsAg) positive (0. 41% vs 0.28%, respectively) with a peak at a younger age for males and older age for females. Males are more frequently exposed to HBV and become carriers more often than females. For HCV, an opposite gender trend was found, females being infected more frequently (0. 49%) than males (0.37%). Statistical differences were found among geographical areas of the island. Hence, Crete is an area of low endemicity for HBsAg in blood donors. The HCV infectivity is more similar to Northern Europe than to other neighbouring countries. Differences in geographical distribution within the island and during different years indicate the need for extended epidemiological surveys for valid results.

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Natural history of advanced hepatocellular carcinoma in Crete. Association with hepatitis C virus

Cited by 15 publications

References 0 publications

Octreotide for Cancer of the Liver and Biliary Tree

Octreotide for Cancer of the Liver and Biliary Tree

Prevalence of hepatitis B and C markers in high-risk hospitalised patients in Crete: a five-year observational study

Prevalence of hepatitis B and C markers in volunteer blood donors in Crete. A 5‐year study

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