Natural history of acute and chronic hepatitis B: The role of HBV genotypes and mutants

Lin, Chih–Lin; Kao, Jia‐Horng

doi:10.1016/j.bpg.2017.04.010

Cited by 153 publications

(147 citation statements)

References 99 publications

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“…Genetic variation, environmental factors and genome variability are some of the multiple factors that influence chronic HBV infection . There exist remarkable differences in the geographical distribution of HBV genotypes …”

Section: Introductionmentioning

confidence: 99%

Hepatitis B virus infection in Taiwan: The role of NTCP rs2296651 variant in relation to sex

Nfor

Debnath

et al. 2018

Journal of Viral Hepatitis

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Sodium taurocholate cotransporting polypeptide (NTCP) is a functional receptor for hepatitis B virus (HBV) infection. NTCP rs2296651 is believed to be an Asian-specific variant responsible for HBV susceptibility. We investigated the relationship between rs2296651 and HBV infection in Taiwan based on stratification by gender and menopausal status. We recruited 10 017 Taiwan Biobank participants aged 30-70 years with complete genetic data and sociodemographic information. Gender-stratified multivariate logistic regression models were used to determine the relationship between NTCP variant and HBV infection. Among individuals with HBV infection, the genotype frequencies of GG, AG and AA in women were 0.85, 0.15 and 0 while those in men were 0.82, 0.18 and 0, respectively. The multivariate-adjusted odds ratios (OR) of HBV infection were 0.77 (95% CI 0.59-0.10) in women and 0.98 (95% CI 0.79-1.20) in men. The adjusted OR was 0.87 (CI 0.63-1.19) in premenopausal and 0.59 (0.36-0.97) in postmenopausal women. We found that genetic variation in the HBV receptor gene (NTCP) was significantly associated with a decreased risk of HBV infection in Taiwanese women.

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Section: Introductionmentioning

confidence: 99%

Hepatitis B virus infection in Taiwan: The role of NTCP rs2296651 variant in relation to sex

Nfor

Debnath

et al. 2018

Journal of Viral Hepatitis

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“…Ten genotypes of HBV have been identified labeled A through J . The prevalence of HBV genotypes varies geographically.…”

Section: Selected Diagnostic Tests Used In Management Of Chronic Hepamentioning

confidence: 99%

“…HBV genotypes A through H have been found in the United States, with genotypes A, B, and C being most prevalent . HBV genotypes may play an important role in the progression of HBV‐related liver disease as well as response to interferon (IFN) therapy . Genotype A (vs. B‐D) is associated with significantly higher rates of HBeAg and HBsAg loss with IFN therapy .…”

Section: Selected Diagnostic Tests Used In Management Of Chronic Hepamentioning

confidence: 99%

“…Genotype A (vs. B‐D) is associated with significantly higher rates of HBeAg and HBsAg loss with IFN therapy . Studies from Asia found that HBV genotype B is associated with HBeAg seroconversion at an earlier age, more sustained remission after HBeAg seroconversion, less active hepatic necroinflammation, a slower rate of progression to cirrhosis, and a lower rate of HCC development compared with genotype C . Studies from Alaska also show that HBeAg seroconversion occurs on average 2 decades later in persons infected with HBV genotype C than in those infected with HBV genotypes A, B, D, or F .…”

Section: Selected Diagnostic Tests Used In Management Of Chronic Hepamentioning

confidence: 99%

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Update on prevention, diagnosis, and treatment of chronic hepatitis B: AASLD 2018 hepatitis B guidance

et al. 2018

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“…Another point to consider is the fact that the current study was performed only with one HBV isolate/genotype (genotype D). The HBV genotype is known to affect viral pathogenesis, disease progression, and response to treatment with interferon-alpha (Lin and Kao, 2017). As chronic HBV infection is not a homogenous disease with singular clinical presentation, studies with varying degrees of infection rates and/or different HBV genotypes are warranted to inform about the changes in ADME profile of a HBV compound in healthy and diseased states.…”

Section: Future Applications -Diseased Statementioning

confidence: 99%

Simultaneous Assessment of Clearance, Metabolism, Induction, and Drug-Drug Interaction Potential Using a Long-Term In Vitro Liver Model for a Novel Hepatitis B Virus Inhibitor

Kratochwil

Triyatni

Mueller

et al. 2018

J Pharmacol Exp Ther

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Natural history of acute and chronic hepatitis B: The role of HBV genotypes and mutants

Cited by 153 publications

References 99 publications

Hepatitis B virus infection in Taiwan: The role of NTCP rs2296651 variant in relation to sex

Hepatitis B virus infection in Taiwan: The role of NTCP rs2296651 variant in relation to sex

Update on prevention, diagnosis, and treatment of chronic hepatitis B: AASLD 2018 hepatitis B guidance

Simultaneous Assessment of Clearance, Metabolism, Induction, and Drug-Drug Interaction Potential Using a Long-Term In Vitro Liver Model for a Novel Hepatitis B Virus Inhibitor

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