Natural history, diagnosis, treatment and outcome of medullary thyroid cancer: 37 years experience on 157 patients

Pelizzo, Maria Rosa; Boschin, Isabella Merante; Bernante, Paolo; Toniato, Antonio; Piotto, Andrea; Pagetta, Costantino; Nibale, Otello; Rampin, Lucia; Muzzio, Pier Carlo; Rubello, Domenico

doi:10.1016/j.ejso.2006.10.021

Cited by 173 publications

(143 citation statements)

References 14 publications

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“…The literature reports 25% of all medullary thyroid carcinomas being familial. 38,39 These results found are in line with a population based study which included the SEER population for the period 1973-1991. 35 The 5 year relative survival of the endocrine carcinoma of the thyroid gland (82%) was by far the best seen within NETs (Fig.…”

Section: Discussionsupporting

confidence: 86%

Rare neuroendocrine tumours: Results of the surveillance of rare cancers in Europe project

Zwan

Trama

Otter

et al. 2013

European Journal of Cancer

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Section: Discussionsupporting

confidence: 86%

Rare neuroendocrine tumours: Results of the surveillance of rare cancers in Europe project

Zwan

Trama

Otter

et al. 2013

European Journal of Cancer

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“…Pelizzo discovered the same after a 37-year follow-up of a 157 patients but also add extent of surgery as a prognostic factor [7]. This implies that a more advanced tumor requires more extensive surgery and both relate to poor prognosis.…”

Section: The Evasiveness Of Follow-upmentioning

confidence: 78%

Medullary thyroid carcinoma: Management and complexities of postoperative follow-up

Saeed¹,

Sakrani²,

Juma³

et al. 2017

IJCRI

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International Journal of Case Reports and Images (IJCRI) is an international, peer reviewed, monthly, open access, online journal, publishing high-quality, articles in all areas of basic medical sciences and clinical specialties.Aim of IJCRI is to encourage the publication of new information by providing a platform for reporting of unique, unusual and rare cases which enhance understanding of disease process, its diagnosis, management and clinico-pathologic correlations. Although calcitonin is an apparent marker, levels of carcinoembryonic antigen (CEA) can also be used. In patients that are surgically managed, calcitonin levels can begin to rapidly decline within the first postoperative hour. Case Report: This paper presents a case of 37-year-old Indian female treated for medullary thyroid carcinoma and followed-up over a year. Fine-needle aspiration cytology (FNAC) biopsy was reported as highly suspicious of malignancy. The patient underwent a near total thyroidectomy and the following histopathology report confirmed medullary carcinoma. Conclusion: This paper highlights the importance of biochemical follow-up of calcitonin level, following surgical resection in cases of medullary thyroid carcinoma as a part of postoperative care.

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“…In our institution patients diagnosed with medullary thyroid cancer (MTC) were not categorised into sporadic and familial cases [3][4][5][6][7] and thus not grouped as such in this review. We found that MTC was the third common thyroid malignancy.…”

Section: Discussionmentioning

confidence: 99%

“…The majority of MTCs are sporadic, but approximately 20% of MTCs are as a result of a germline genetic mutation in the rearranged during transfection (ret) proto-oncogene. Hereditary MTC can be seen in isolation (familial medullary thyroid cancer [FMTC]) or as part of the multiple endocrine neoplasia (MEN) syndrome type 2 (2A or 2B) [3][4][5][6]. The associations of MTC and neuroendocrine disorders was described by Steiner and colleagues in 1968 [7].…”

Section: Introductionmentioning

confidence: 99%

Pathological and clinical findings in a series of 22 cases of medullary carcinoma of the thyroidat the korle-bu teaching hospital (1994-2013)

Der¹

2017

Pathol Discov

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There is paucity of published data on medullary thyroid cancer (MTC) as a single entity in Ghana and Africa as a whole despite its first description six decades ago. The aim of this study was to determine the proportions of thyroid malignancies diagnosed in the department of pathology of the Korle-Bu Teaching Hospital (KBTH) between 1994-2013 that were MTCs and the clinicopathological characteristics by a retrospective histopathological study. Material and methods:This was a retrospective study in KBTH from 1994 to 2013. Results: During the period under review, MTC was found to be the third common thyroid malignancy, accounting for 10.0% of all the cases. The mean age of patient was 38.4 years (SD±16.0) with half (50.0%) being younger than 40 years of age. The male to female ratio was 1:1. The modal age of the males was 40 -49 years (27.3%), but that for the females was 20-29 years (36.4%). Anterior neck swelling was the commonest presentation of MTCs (95.5%), particularly diffuse gland involvement (45.5%). Males with MTC presented relatively early within two years (50.0%), compared to females who commonly presented after 5 years (37.5%) with the disease. AMTCs were commonly diagnosed in lobectomy specimens (44.4%). Two of the females had neck dissection (18.2%). Extra-glandular spread at diagnosis was found in lymph nodes (22.7%), lymphovascular space (13.6%) and neck muscles (13.6%). Conclusion: Medullary thyroid cancer was found to be the third common thyroid malignancy at KBTH with no significant sex differences in the clinical presentation. Patients commonly presented with large anterior neck swelling of variable duration. Approximately 59.1% of the patients had organ confirmed disease at diagnosis.

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Natural history, diagnosis, treatment and outcome of medullary thyroid cancer: 37 years experience on 157 patients

Cited by 173 publications

References 14 publications

Rare neuroendocrine tumours: Results of the surveillance of rare cancers in Europe project

Rare neuroendocrine tumours: Results of the surveillance of rare cancers in Europe project

Medullary thyroid carcinoma: Management and complexities of postoperative follow-up

Pathological and clinical findings in a series of 22 cases of medullary carcinoma of the thyroidat the korle-bu teaching hospital (1994-2013)

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