Natural History Data in Symptomatic Severe Aortic Stenosis Alerts Cardiologists to the Dangers of No Action

Lee, Hyun Jung; Kim, Yong Jin

doi:10.4070/kcj.2018.0344

Cited by 2 publications

(2 citation statements)

References 9 publications

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“…Most patients with CAVD are asymptomatic and are often discovered on diagnostic testing 39 . The initial presentation of the disease is often delayed until the valve orifice is narrowed to less than 1 cm 2 .…”

Section: Clinical Featuresmentioning

confidence: 99%

Insights into calcific aortic valve stenosis: a comprehensive overview of the disease and advancing treatment strategies

Jain,

Goyal,

Khan

et al. 2024

Annals of Medicine &Amp; Surgery

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Aortic valve stenosis is a disease characterized by thickening and narrowing of the aortic valve (AV), most commonly due to calcification, which leads to left ventricular outflow obstruction called calcific aortic valve disease (CAVD). CAVD presents as a progressive clinical syndrome with cardiorespiratory symptoms, often with rapid deterioration. The modern-day pathophysiology of CAVD involves a complex interplay of genetic factors, chronic inflammation, lipid deposition, and valve calcification, with early CAVD stages resembling atherosclerosis. Various imaging modalities have been used to evaluate CAVD, with a recent trend of using advanced imaging to measure numerous AV parameters, such as peak jet velocity. Significant improvements in mortality have been achieved with transcatheter AV repair, but numerous therapeutics and modalities are being researched to delay the progression of CAVD. This article aims to provide a comprehensive review of CAVD, explore recent developments, and provide insights into future treatments with various novel modalities.

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Section: Clinical Featuresmentioning

confidence: 99%

Insights into calcific aortic valve stenosis: a comprehensive overview of the disease and advancing treatment strategies

Jain,

Goyal,

Khan

et al. 2024

Annals of Medicine &Amp; Surgery

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“…Progression rate correlates with AS severity, which seems to progress faster with higher mean gradient. Moderate AS progress, with aortic valve area, decreases on average by 0.1 cm 2 per cent annually the pressure gradient across the valve rises on average by 7 mm Hg per year, and the jet velocity increases by 0.3 m/s per year [40,41]. The definitions of the conditions "low-gradient AS" and "high-gradient AS" are the most relevant new changes in the recommendations for the management of aortic valve stenosis (AS).…”

Section: Natural Historymentioning

confidence: 99%

Aortic Valve Disease: State of the Art

Gamel¹

2021

Advances in Complex Valvular Disease

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Aortic valve replacement is the most commonly performed valve operation. It has been shown to be an effective therapy in all age groups, including the very elderly (age > 90 years). The most common etiologies for aortic stenosis are calcific degeneration, rheumatic disease, and congenital bicuspid valves. The most common causes of pure aortic regurgitation include annuloaortic ectasia and associated dilation of the aortic root, endocarditis, aortic dissection, and rheumatic disease. The indications for surgery depend on the pathophysiology and symptoms. The choice of the prosthesis can be difficult and depends on multiple clinical and lifestyle considerations. Early and late outcomes are generally quite good, even in high-risk patients.

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Natural History Data in Symptomatic Severe Aortic Stenosis Alerts Cardiologists to the Dangers of No Action

Cited by 2 publications

References 9 publications

Insights into calcific aortic valve stenosis: a comprehensive overview of the disease and advancing treatment strategies

Insights into calcific aortic valve stenosis: a comprehensive overview of the disease and advancing treatment strategies

Aortic Valve Disease: State of the Art

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