Natural history and treatment outcome of radiotherapy for Kimura’s disease

Muangwong, Pooriwat; Chitapanarux, Imjai; Ya-In, Charin; Klibngern, Hanpon; Kongmebhol, Pailin

doi:10.4103/ijc.ijc_69_20

Cited by 2 publications

(1 citation statement)

References 12 publications

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“…In this study, of all three recurrent patients, one was treated with surgical resection alone, and two received oral corticosteroid therapy alone. Local radiation therapy is impressive in treating recurrent or persistent lesions with a high local control rate and is also recommended in patients with positive surgical margins and repeated postoperative recurrences (36,37). Ye et al argued that there was a lower local recurrence rate in patients with KD treated by surgery combined with radiotherapy (38).…”

Section: Discussionmentioning

confidence: 99%

Kimura disease in children: A report of 11 cases and review of the literature

Mai

Wang²,

Sun³

et al. 2023

Front. Pediatr.

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IntroductionKimura disease (KD), also known as eosinophilic hyperplastic lymphoid granuloma, is a rare benign chronic inflammatory condition, which is featured with the painless progressive mass located in the subcutaneous area of the head and neck region, elevated peripheral blood eosinophils, and raised serum immunoglobulin E (IgE) levels. KD is uncommon in clinical practice, especially with low incidence in children, so it often leads to misdiagnosis or missed diagnosis in pediatric patients.MethodsThe clinical data of 11 pediatric patients with KD in the authors' institution were retrospectively analyzed.ResultsThere were 11 pediatric patients with KD enrolled in total, including 9 male patients and 2 female patients (sex ratio 4.5:1). The median age at diagnosis stood at 14 years (range 5-18 years), the initial symptoms in all patients included painless subcutaneous masses and focal swelling, the duration of symptoms ranged from 1 month to 10 years, and the average duration was 24.45 months. Six patients had single lesions, and 5 had multiple lesions. The highest proportion of lesion regions were parotid gland (n = 5, 31.3%) and retroauricular (n = 5, 31.3%), followed by cervical lymph nodes (n = 4, 25%), and others (n = 2,12.5; elbow n = 1; back n = 1). The eosinophil absolute count elevated in all patients, ranging from 0.71×109/L to 10.35 ×109/L (normal range 0.02-0.52×109/L). IgE levels were increased in all 7 patients who underwent serum immunoglobulin examination (normal range <100 IU/mL). Three patients received oral corticosteroid treatment while 2 relapsed. Three patients received surgical resection combined with oral corticosteroid treatment, and no patient relapsed. The other 3 patients received surgery and radiotherapy, surgery combined with corticosteroid and cyclosporin and corticosteroid combined with leflunomide respectively, and no patient relapsed.ConclusionBase on the study, it is found that Kimura disease is rare and may have the atypical symptoms in pediatric patients, combination therapy is recommended to reduce recurrence, and long-term follow-up should be performed.

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Section: Discussionmentioning

confidence: 99%

Kimura disease in children: A report of 11 cases and review of the literature

Mai

Wang²,

Sun³

et al. 2023

Front. Pediatr.

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Clinical results of definitive radiotherapy for local recurrent kimura disease in the head and neck after surgery: A retrospective study

Lv,

Li,

Liu

et al. 2024

Precision Radiation Oncology

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ObjectiveTo evaluate the efficacy and safety of definitive radiotherapy in selected patients with local recurrence of Kimura disease of the head and neck after surgery.MethodsThis retrospective study collected the clinical data of 14 patients with postoperative recurrence of Kimura disease of the head and neck who received definitive radiotherapy at the First Affiliated Hospital of Fujian Medical University between 2006 and 2022. The radiation dose ranged from 28 to 40 Gy. Its efficacy and safety were analyzed.ResultsDuring follow‐up, ranging from 17 to 168 months, local control was achieved in 13 (92.9%) of the 14 patients with postoperative recurrence. There were no serious late toxicities except for mild xerostomia in four (28.6%) patients; the patients’ peripheral blood eosinophil count dropped from 1.73×109/L before treatment to 0.42×109/L after treatment, and the eosinophil percentage dropped from 20.64% to 9.78%. Both changes were statistically significant (p<0.001).ConclusionsThe findings of the study suggest that definitive radiotherapy is a viable and effective alternative to repeated surgery for managing recurrent Kimura disease of the head and neck, with significant response rates and a good safety profile. Peripheral blood eosinophil counts and percentages serve as simple and reliable biomarkers for monitoring Kimura disease progression and treatment responses.

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Natural history and treatment outcome of radiotherapy for Kimura’s disease

Cited by 2 publications

References 12 publications

Kimura disease in children: A report of 11 cases and review of the literature

Kimura disease in children: A report of 11 cases and review of the literature

Clinical results of definitive radiotherapy for local recurrent kimura disease in the head and neck after surgery: A retrospective study

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