Natural History and Possible Reactivation of Human Papillomavirus in Human Immunodeficiency Virus–Positive Women

Strickler, Howard D.; Burk, Robert D.; Fazzari, Melissa; Anastos, Kathryn; Minkoff, Howard; Massad, L. Stewart; Hall, Charles B.; Bacon, Melanie C.; Levine, Alexandra M.; Watts, D. Heather; Silverberg, Michael J.; Xue, Xiaonan; Schlecht, Nicolas F.; Melnick, Sandra; Palefsky, Joel M.

doi:10.1093/jnci/dji073

Cited by 461 publications

(510 citation statements)

References 48 publications

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“…We also found that HIV-1 infection was independently associated with an increase in SIL among HPV-positive women and that HIV-1 represented an important risk factor for the presence of HSIL. These findings are in agreement with other African series (La Ruche et al, 1998;Chirenje et al, 2002;Hawes et al, 2003) and with many studies in industrialised countries (Sun et al, 1997;Ahdieh et al, 2001;Moscicki et al, 2004b;Strickler et al, 2005).…”

Section: Discussionsupporting

confidence: 93%

“…Furthermore, the high background prevalence of human immunodeficiency virus type 1 (HIV-1) observed in many African settings adds complexity to our understanding of the epidemiology of HPV and cervical neoplasia. Studies conducted in industrialised countries have shown that HIV-1 alters the natural history of HPV infection by upregulating HPV persistence and recurrences, thereby facilitating progression to high-grade lesions and cancer (Sun et al, 1997;Ahdieh et al, 2001;Strickler et al, 2005). Consequently, cervical cancer has been included in the list of AIDS-defining opportunistic conditions by the Centres for Disesase Control and Prevention (Centers for Disease Control and Prevention, 1993).…”

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confidence: 99%

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Human papillomavirus genotype distribution and cervical squamous intraepithelial lesions among high-risk women with and without HIV-1 infection in Burkina Faso

et al. 2006

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Human papillomavirus (HPV) infection and cervical squamous intraepithelial lesions (SILs) were studied in 379 high-risk women. Human papillomavirus DNA was detected in 238 of 360 (66.1%) of the beta-globin-positive cervical samples, and 467 HPV isolates belonging to 35 types were identified. Multiple (2 -7 types) HPV infections were observed in 52.9% of HPV-infected women. The most prevalent HPV types were HPV-52 (14.7%), HPV-35 (9.4%), HPV-58 (9.4%), HPV-51 (8.6%), HPV-16 (7.8%), HPV-31 (7.5%), HPV-53 (6.7%), and HPV-18 (6.4%). Human immunodeficiency virus type 1 (HIV-1) seroprevalence was 36.0%. Human papillomavirus prevalence was significantly higher in HIV-1-infected women (87 vs 54%, prevalence ratio ( Cervical cancer is the most frequent cancer of women in developing countries, particularly in sub-Saharan Africa (Parkin et al, 1999), and it is now well established that genital infection with certain types of human papillomavirus (HPV) causes virtually all cases of cervical intraepithelial neoplasia (CIN) and invasive cervical cancer (ICC) (Walboomers et al, 1999). The HPV types that infect the genital tract have been subdivided into low-risk (LR) types, which are principally found in nonmalignant lesions such as genital warts, and high-risk (HR) types, which are associated with the development of CIN and ICC. Human papillomavirus types 6, 11, 40, 42, 43, 44, 54, 61, 70, 72, 81, and 89 are classified as LR types, whereas types 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 68, 73, and 82 are classified as HR types. In addition, HPV types 26, 53, and 66 are considered as probably carcinogenic (Muñoz et al, 2003).Human papillomavirus prophylactic vaccines are now being developed and promising results have been obtained with recombinant L1 capsid protein virus-like particles (VLPs). However, the current HPV vaccines target the most prevalent high-risk HPV (HR-HPV) types worldwide, namely HPV-16 and HPV-18 (Koutsky et al, 2002;Ault et al, 2004;Brown et al, 2004;Harper et al, 2004). It has been shown that crossneutralisation induced by L1 VLPs represents less than 1% of the neutralising activity induced by the dominant conformational epitope , indicating that current HPV vaccines would be able to confer only type-specific immunity. Therefore, effectiveness of these vaccines on the prevention of cancer may be lower in populations highly affected by HR-HPV types other than HPV-16 and HPV-18. Thus, it is important to document the distribution of HPV genotypes in HPV-infected women and in women with cervical neoplasia in African countries in order to assess the potential effectiveness of a bivalent HPV-16/18 vaccine.There have been few detailed studies of HPV genotypes and their association with intraepithelial lesions or ICC in sub-Saharan Africa. Available data suggest, however, a higher prevalence and wider spectrum of oncogenic HPV types compared to studies conducted elsewhere (Castellsague et al, 2001;De Vuyst et al, 2003;Mayaud et al, 2003;Clifford et al, 2005;Wall et al, 2005). Furthermore, the high backgr...

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Section: Discussionsupporting

confidence: 93%

mentioning

confidence: 99%

Human papillomavirus genotype distribution and cervical squamous intraepithelial lesions among high-risk women with and without HIV-1 infection in Burkina Faso

et al. 2006

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“…Among women, RTIs often go undiagnosed and untreated. It is a burden of asymptomatic disease, which is responsible for the frequent and severe long-term morbidity and in part for the persistence and spread of sexually transmitted diseases (STIs) in the community [2].…”

Section: Discussionmentioning

confidence: 99%

“…Keywords HIV Á Squamous cell abnormalities Á Intraepithelial lesions Á Pap smear Introduction HIV-infected women have a higher risk of human papilloma virus (HPV)-associated cervical intraepithelial neoplasia as compared to HIV-uninfected women [1][2][3][4][5]. The overwhelming majority of women affected by this completely preventable disease reside in resource-constrained nations where access to screening services is limited or non-existent.…”

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confidence: 99%

A Study of Pap Smear in HIV-Positive Females

Madan

Patil

Nakate

2016

J Obstet Gynecol India

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“…Die Ursache für eine Viruspersistenz ist unklar, hängt aber vermutlich ebenfalls mit einem Versagen der T-Zell-vermittelten Immunität ab, wie die deutlich höheren Raten persistierender und progredienter HR-HPV-Infektionen bei immunsupprimierten oder HIV-positiven HR-HPV-infizierten Menschen zeigen [29].…”

Section: Hpv-persistenzunclassified

Die Infektion mit humanen Papillomaviren

Sotlar

2008

Pathologe

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Natural History and Possible Reactivation of Human Papillomavirus in Human Immunodeficiency Virus–Positive Women

Cited by 461 publications

References 48 publications

Human papillomavirus genotype distribution and cervical squamous intraepithelial lesions among high-risk women with and without HIV-1 infection in Burkina Faso

Human papillomavirus genotype distribution and cervical squamous intraepithelial lesions among high-risk women with and without HIV-1 infection in Burkina Faso

A Study of Pap Smear in HIV-Positive Females

Die Infektion mit humanen Papillomaviren

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