Natural history and patterns of recovery of contractile function in single left ventricle after Fontan operation.

Sluysmans, Thierry; Sanders, Stephen P.; Velde, Mary van der; Matitiau, Abraham; Parness, Ira A.; Spevak, Philip J.; Mayer, John E.; Colan, Steven D.

doi:10.1161/01.cir.86.6.1753

Cited by 92 publications

(47 citation statements)

References 51 publications

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“…22 From the results of our comparative study, matrixarray 3DE can now be applied to the serial analysis of ventricular size and function in patients with functional single ventricles.…”

Section: Discussionmentioning

confidence: 99%

Matrix-Array 3-Dimensional Echocardiographic Assessment of Volumes, Mass, and Ejection Fraction in Young Pediatric Patients With a Functional Single Ventricle

et al. 2008

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Background-Quantitative assessment of ventricular volumes and mass in pediatric patients with single-ventricle physiology would aid clinical management, but it is difficult to obtain with 2-dimensional echocardiography. The purpose of the present study was to compare matrix-array 3-dimensional echocardiography (3DE) measurements of single-ventricle volumes, mass, and ejection fraction with those measured by cardiac magnetic resonance (CMR) in young patients. Methods and Results-Twenty-nine patients (median age, 7 months) with a functional single ventricle undergoing CMR under general anesthesia were prospectively enrolled. The 3DE images were acquired at the conclusion of the CMR. Twenty-seven of 29 3DE data sets (93%) were optimal for 3DE assessment. Two blinded and independent observers performed 3DE measurements of volume, mass, and ejection fraction. The 3DE end-diastolic volume correlated well (rϭ0.96) but was smaller than CMR by 9% (PϽ0.01), and 3DE ejection fraction was smaller than CMR by 11% (PϽ0.01). There was no significant difference in measurements of end-systolic volume and mass. The 3DE interobserver differences for mass and volumes were not significant except for ejection fraction (8% difference; PϽ0.05). Intraobserver differences were not significant. Conclusions-In young pediatric patients with a functional single ventricle, matrix-array 3DE measurements of mass and volumes compare well with those obtained by CMR. 3DE will provide an important modality for the serial analysis of ventricular size and performance in young patients with functional single ventricles.

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“…22 From the results of our comparative study, matrixarray 3DE can now be applied to the serial analysis of ventricular size and function in patients with functional single ventricles.…”

Section: Discussionmentioning

confidence: 99%

Matrix-Array 3-Dimensional Echocardiographic Assessment of Volumes, Mass, and Ejection Fraction in Young Pediatric Patients With a Functional Single Ventricle

et al. 2008

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“…(85) The Fontan operation leads to early improvements in ventricular function and hypertrophy. (86)(87)(88) By adult life the gains in ventricular function are largely lost with around a third of reported patients having moderate or severe ventricular function.…”

Section: Ventricular Dysfunctionmentioning

confidence: 99%

Management of the Fontan circulation in the adult patient

Clift

2017

SAHJ

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“…Earlier age at volume-unloading surgery was associated with improved odds of reversing the abnormal ventricular mechanics. 12 Studies have also begun to link cardiac magnetic resonance measurements with clinical variables. For example, in children after repair of TOF, RV ejection fraction but not degree of pulmonary regurgitation or stenosis, has been shown to correlate with exercise capacity.…”

Section: Noninvasive Imagingmentioning

confidence: 99%

Heart Failure in Children

Hsu

Pearson

2009

Circ: Heart Failure

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Natural history and patterns of recovery of contractile function in single left ventricle after Fontan operation.

Abstract: Although Fontan-type repair of single ventricle early in life is associated with reversal of the abnormal contractile mechanics associated with age and volume load, this capacity for recovery diminishes with age at surgery.

Cited by 92 publications

References 51 publications

Matrix-Array 3-Dimensional Echocardiographic Assessment of Volumes, Mass, and Ejection Fraction in Young Pediatric Patients With a Functional Single Ventricle

Matrix-Array 3-Dimensional Echocardiographic Assessment of Volumes, Mass, and Ejection Fraction in Young Pediatric Patients With a Functional Single Ventricle

Management of the Fontan circulation in the adult patient

Heart Failure in Children

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