Natural history and mid-term neurodevelopmental outcome of fetuses with isolated mild ventriculomegaly diagnosed in the second half of pregnancy

Gómez‐Arriaga, P.I.; Núñez, Noemí; Zamora, Berta; Villalaín, Cecilia; Risco, Beatriz; Liébana, Constanza; Herraı̀z, Ignacio; Izquierdo, Alberto Galindo

doi:10.1080/14767058.2023.2214836

Cited by 3 publications

(1 citation statement)

References 22 publications

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“…The Gesell Development Scale, a scale that explores in-depth ve domains of development, can detect the presence of subtle alterations which may be otherwise unnoticed. Among the follow-up indicators, IVM foetuses were more likely to have delayed language (28%) and ne motor development (20%), similar to previous reports [6,26,27] . Although the visual cortex is typically not regarded as a constituent of the neural networks associated with language and hearing, it does contribute to speech perception by processing the visual components of speech [28] .…”

Section: Follow-up Analysissupporting

confidence: 88%

Volume development changes in the occipital lobe gyrus assessed by MRI in foetuses with isolated ventriculomegaly correlate with neurological development in infancy and early childhood

Liu,

Zhang,

Chen

et al. 2023

Preprint

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OBJECTIVE The purpose of this study was to systematically assess the occipital lobe grey and white matter volume of Isolated ventriculomegaly foetuses with MRI and to follow up on the neurodevelopment of participants. Method MRI was used to evaluate 37 IVM group foetuses and 37 control group foetuses. The volume of grey and white matter in each foetal occipital gyrus was manually segmented and compared, and neurodevelopment was followed up and assessed in infancy and early childhood. Results Compared with the control group, the volume of gray matter in occipital lobes increased in IVM group, and the incidence of neurodevelopmental delay increased. Conclusions We tested the hypothesis that antenatally diagnosed IVM represents a biological marker for development in foetal occipital lobe. The IVM group showed differences in occipital grey matter development and had a higher risk of neurodevelopmental delay.

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Section: Follow-up Analysissupporting

confidence: 88%

Volume development changes in the occipital lobe gyrus assessed by MRI in foetuses with isolated ventriculomegaly correlate with neurological development in infancy and early childhood

Liu,

Zhang,

Chen

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

Volume development changes in the occipital lobe gyrus assessed by MRI in fetuses with isolated ventriculomegaly correlate with neurological development in infancy and early childhood

Zhang,

Chen,

et al. 2024

J Perinatol

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The purpose of this study was to systematically assess the occipital lobe grey and white matter volume of Isolated ventriculomegaly foetuses with MRI and to follow up on the neurodevelopment of participants. MethodMRI was used to evaluate 37 IVM group foetuses and 37 control group foetuses. The volume of grey and white matter in each foetal occipital gyrus was manually segmented and compared, and neurodevelopment was followed up and assessed in infancy and early childhood. ResultsCompared with the control group, the volume of gray matter in occipital lobes increased in IVM group, and the incidence of neurodevelopmental delay increased. ConclusionsWe tested the hypothesis that antenatally diagnosed IVM represents a biological marker for development in foetal occipital lobe. The IVM group showed differences in occipital grey matter development and had a higher risk of neurodevelopmental delay.

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Isolated Fetal Ventriculomegaly: Diagnosis and Treatment in the Prenatal Period

Zamłyński,

Zhemela,

Olejek

2024

Children

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Fetal ventriculomegaly (VM) is a defect of the central nervous system, typically diagnosed during the second-trimester ultrasound in fetuses with an atrial diameter (AD) of >10 mm. Non-isolated ventriculomegaly (NIVM) is heterogeneous in nature, coexisting with additional intracranial and/or extracranial malformations and genetic syndromes, resulting in an unfavorable prognosis for the further development of the child. Both the pregnancy management and counseling are dependent on the findings of combined ultrasound/MRI, genetic testing, and gestational age at diagnosis. The purpose of this review is to propose a hypothesis that diagnostic advancements allow to define the process of identification of the isolated forms of VM (IVM). Based on the evidence presented in the literature, we consider whether prenatal decompression for severe isolated VM (ISVM) is supported by the experimental trials and whether it might be implemented in clinical practice. Also, we describe the evolution of the diagnostic methods and expert opinions about the previously used prenatal decompression techniques for ISVM. In conclusion, we introduce the idea that fetal surgery centers have either reached or nearly reached the necessary level of expertise to perform such procedures. Endoscopic cystoventriculostomy (ETV) appears to be the most promising, as it is associated with minimal perinatal complications and favorable neurological outcomes in the neonatal period. Randomized trials with long-term neurodevelopmental follow-up of children who underwent prenatal decompression due to ISVM are necessary.

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Natural history and mid-term neurodevelopmental outcome of fetuses with isolated mild ventriculomegaly diagnosed in the second half of pregnancy

Cited by 3 publications

References 22 publications

Volume development changes in the occipital lobe gyrus assessed by MRI in foetuses with isolated ventriculomegaly correlate with neurological development in infancy and early childhood

Volume development changes in the occipital lobe gyrus assessed by MRI in foetuses with isolated ventriculomegaly correlate with neurological development in infancy and early childhood

Volume development changes in the occipital lobe gyrus assessed by MRI in fetuses with isolated ventriculomegaly correlate with neurological development in infancy and early childhood

Isolated Fetal Ventriculomegaly: Diagnosis and Treatment in the Prenatal Period

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