Natural History and Familial Relationships of Infant Spilling to 9 Years of Age

Martin, Andrew; Pratt, Nicole; Kennedy, J. D.; Ryan, Patrick; Ruffin, R.; Miles, Helen; Marley, John

doi:10.1542/peds.109.6.1061

Cited by 227 publications

(174 citation statements)

References 31 publications

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“…This prevalence is similar to the one described in the literature, regardless of the diagnostic criteria used, 4,5,[17][18][19][20] suggesting that the use of the Rome Criteria may be useful in identifying infants who do not meet the criteria for IR and who therefore have to be more carefully evaluated.…”

Section: Discussionsupporting

confidence: 82%

“…4,5,[18][19][20] Prevalence decreases with age, characterizing the benign course of the disorder, contrary to GERD, where prevalence increases with age.…”

Section: Discussionmentioning

confidence: 99%

“…The following parameters were used: estimated prevalence of PGER in infants (10%), 4,6,[18][19][20] a variation of this prevalence around 25% and a 95% confidence interval (95%CI). The minimal sample size corresponded to 553 infants, but 798 were studied.…”

Section: Methodsmentioning

confidence: 99%

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Prevalência de refluxo gastroesofágico patológico em lactentes regurgitadores

Costa¹,

Silva²,

Gouveia³

et al. 2004

J. Pediatr. (Rio J.)

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Objective: To determine the prevalence of pathologic gastroesophageal reflux in a group of regurgitant infants attended at Helena Moura Hospital, Recife, State of Pernambuco, Brazil. The clinical criteria employed were based on Rome II criteria. Method:The study design was transversal. The patients were all children of less than 1 year of age with a history of episodes of regurgitation for at least 3 weeks. The study group was comprised of 798 children who attended the program between January and August of 2002. The diagnostic criteria were based on Rome II criteria.Results: The prevalence of pathologic gastroesophageal reflux was 11.15% (89/798) (95% CI 9.10-13.48). It was higher during the first two trimesters of life, 14.62% (31/212) (95% CI 10.33-19.86) in the first trimester, and 13.76% (38/276) (95% CI 10.07-18.21) in the second trimester. Conclusion:The prevalence of pathologic gastroesophageal reflux within the group of children examined concurred with previously published studies, with predominance, therefore, of regurgitant infants.

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Section: Discussionsupporting

confidence: 82%

“…4,5,[18][19][20] Prevalence decreases with age, characterizing the benign course of the disorder, contrary to GERD, where prevalence increases with age.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Prevalência de refluxo gastroesofágico patológico em lactentes regurgitadores

Costa¹,

Silva²,

Gouveia³

et al. 2004

J. Pediatr. (Rio J.)

View full text Add to dashboard Cite

show abstract

“…6 Less is known about the normal physiology of GER in infants and children, but regurgitation or spitting up, as the most visible symptom, is reported to occur daily in 50% of all infants. 7,8 In both infants and children, reflux can also be associated with vomiting, defined as a forceful expulsion of gastric contents via a coordinated autonomic and voluntary motor response. Regurgitation and vomiting can be further differentiated from rumination, in which recently ingested food is effortlessly regurgitated into the mouth, masticated, and reswallowed.…”

Section: Introductionmentioning

confidence: 99%

Gastroesophageal Reflux: Management Guidance for the Pediatrician

Lightdale¹,

Gremse²,

2013

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Recent comprehensive guidelines developed by the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition define the common entities of gastroesophageal reflux (GER) as the physiologic passage of gastric contents into the esophagus and gastroesophageal reflux disease (GERD) as reflux associated with troublesome symptoms or complications. The ability to distinguish between GER and GERD is increasingly important to implement best practices in the management of acid reflux in patients across all pediatric age groups, as children with GERD may benefit from further evaluation and treatment, whereas conservative recommendations are the only indicated therapy in those with uncomplicated physiologic reflux. This clinical report endorses the rigorously developed, well-referenced North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition guidelines and likewise emphasizes important concepts for the general pediatrician. A key issue is distinguishing between clinical manifestations of GER and GERD in term infants, children, and adolescents to identify patients who can be managed with conservative treatment by the pediatrician and to refer patients who require consultation with the gastroenterologist. Accordingly, the evidence basis presented by the guidelines for diagnostic approaches as well as treatments is discussed. Lifestyle changes are emphasized as first-line therapy in both GER and GERD, whereas medications are explicitly indicated only for patients with GERD. Surgical therapies are reserved for children with intractable symptoms or who are at risk for life-threatening complications of GERD. Recent black box warnings from the US Food and Drug Administration are discussed, and caution is underlined when using promoters of gastric emptying and motility. Finally, attention is paid to increasing evidence of inappropriate prescriptions for proton pump inhibitors in the pediatric population.

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“…89,90 A randomized trial found no benefit to treatment of symptoms attributed to gastroesophageal reflux disease in infants but did find that medication increased the risk of lower respiratory tract infections. 91 Yet gastroesophageal reflux disease diagnoses and treatments with medication for infants are common and increasing.…”

Section: Gastroesophageal Refluxmentioning

confidence: 99%

Overdiagnosis: How Our Compulsion for Diagnosis May Be Harming Children

et al. 2014

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Overdiagnosis occurs when a true abnormality is discovered, but detection of that abnormality does not benefit the patient. It should be distinguished from misdiagnosis, in which the diagnosis is inaccurate, and it is not synonymous with overtreatment or overuse, in which excess medication or procedures are provided to patients for both correct and incorrect diagnoses. Overdiagnosis for adult conditions has gained a great deal of recognition over the last few years, led by realizations that certain screening initiatives, such as those for breast and prostate cancer, may be harming the very people they were designed to protect. In the fall of 2014, the second international Preventing Overdiagnosis Conference will be held, and the British Medical Journal will produce an overdiagnosis-themed journal issue. However, overdiagnosis in children has been less well described. This special article seeks to raise awareness of the possibility of overdiagnosis in pediatrics, suggesting that overdiagnosis may affect commonly diagnosed conditions such as attention-deficit/hyperactivity disorder, bacteremia, food allergy, hyperbilirubinemia, obstructive sleep apnea, and urinary tract infection. Through these and other examples, we discuss why overdiagnosis occurs and how it may be harming children. Additionally, we consider research and education strategies, with the goal to better elucidate pediatric overdiagnosis and mitigate its influence.

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Natural History and Familial Relationships of Infant Spilling to 9 Years of Age

Cited by 227 publications

References 31 publications

Prevalência de refluxo gastroesofágico patológico em lactentes regurgitadores

Prevalência de refluxo gastroesofágico patológico em lactentes regurgitadores

Gastroesophageal Reflux: Management Guidance for the Pediatrician

Overdiagnosis: How Our Compulsion for Diagnosis May Be Harming Children

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