Natural history and clinical outcomes in patients with portal vein thrombosis by etiology: A retrospective cohort study

Acuña-Villaorduña, Ana; Tran, Vivy; Gonzalez-Lugo, Jesus D.; Aziminekoo, Elham; Billett, Henny H.

doi:10.1016/j.thromres.2018.12.019

Cited by 21 publications

(19 citation statements)

References 13 publications

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“…Postoperative intraabdominal infections are also more common following HBP surgery, and cirrhosis is prevalent in HBP surgery patients, both risk factors for SVT. 10,26 . In our study, cirrhosis and intraabdominal infection were independently associated in multivariable analysis with the occurrence of SVT and 90‐day mortality, but active cancer was not statistically significantly associated with either outcomes.…”

Section: Discussioncontrasting

confidence: 45%

“…Other risk factors for SVT may include myeloproliferative disorders, pancreatitis, and cancer 7,8 . Patients undergoing hepatobiliary and pancreatic (HBP) surgery are likely at particularly higher risk of SVT given that solid cancer is a common indication for HBP interventions and cirrhosis is prevalent in these patients, both risk factors for SVT 6,9,10 . Also, vessel manipulation in the portal system during intraabdominal surgical interventions (also frequent among patients undergoing HPB surgery) has been hypothesized to increase the risk of SVT 11,12 .…”

Section: Introductionmentioning

confidence: 99%

“…Also, vessel manipulation in the portal system during intraabdominal surgical interventions (also frequent among patients undergoing HPB surgery) has been hypothesized to increase the risk of SVT 11,12 . Postoperative inflammation and infection adjacent to the splanchnic veins are among other risk factors that can increase the risk of postoperative SVT in patients undergoing HPB surgery 6,9,10 …”

Section: Introductionmentioning

confidence: 99%

“…7,8 Patients undergoing hepatobiliary and pancreatic (HBP) surgery are likely at particularly higher risk of SVT given that solid cancer is a common indication for HBP interventions and cirrhosis is prevalent in these patients, both risk factors for SVT. 6,9,10 Also, vessel manipulation in the portal system during intraabdominal surgical interventions (also frequent among patients undergoing HPB surgery) has been hypothesized to increase the risk of SVT. 11,12 Postoperative inflammation and infection adjacent to the splanchnic veins are among other risk factors that can increase the risk of postoperative SVT in patients undergoing HPB surgery.…”

Section: Introductionmentioning

confidence: 99%

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Incidence and predictors of splanchnic vein thrombosis and mortality following hepatobiliary and pancreatic surgery

Duceppe

Lauzon

Galliger

et al. 2021

Journal of Thrombosis and Haemostasis

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Background Intraabdominal surgery is a known risk factor for splanchnic vein thrombosis (SVT). SVT incidence, management, and prognosis after hepatopancreatobiliary surgery are unknown. Objectives To determine the incidence and prognosis of SVT following hepatopancreatobiliary surgery and describe current practices in anticoagulation for postoperative SVT. Patients/Methods Multicenter retrospective cohort study of adults undergoing hepatopancreatobiliary surgery. Multivariable analyses for predictors of SVT, major bleeding, and 90‐day mortality were performed. Results Of 1815 patients included, 89 (4.9%) had cirrhosis and 1532 (84.4%) had active cancer. The most frequent surgeries were pancreaticoduodenectomy (40.6%), open (30.7%), and laparoscopic (11.0%) liver resection. Sixty (3.3%) patients experienced SVT within 90 days of surgery. Among patients with SVT, 23.3% were symptomatic and 75.0% were treated with therapeutic anticoagulation. Planned duration of anticoagulation averaged 3 to 6 months. By multivariable analysis, SVT predictors were: operative time (adjusted odds ratio [aOR] per hour increase 1.32, 95% confidence interval [CI] 1.20‐1.46), cirrhosis (aOR 3.22, 95% CI 1.28‐8.10), and postoperative intraabdominal infection (aOR 2.99, 95% CI 1.72‐5.19). Postoperative major bleeding occurred in 22.1% of patients and 4.0% died within 90 days. Predictors of postoperative mortality were age (aOR per 10‐year increase 1.79, 95% CI 1.38‐2.30), operative time (aOR 1.31 (1.17‐1.45), cirrhosis (aOR 4.42, 95% CI 1.96‐9.96), postoperative intraabdominal infection (aOR 2.66, 95% CI 1.55‐4.57), postoperative major bleeding (aOR 4.12, 95% CI 2.36‐7.30), and postoperative SVT (aOR 3.15, 95% CI 1.42‐6.97). Conclusion SVT occurred in 1 in 30 patients after hepatopancreatobiliary surgery and was associated with a 3‐fold independent increase in 90‐day mortality.

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Section: Discussioncontrasting

confidence: 45%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Incidence and predictors of splanchnic vein thrombosis and mortality following hepatobiliary and pancreatic surgery

Duceppe

Lauzon

Galliger

et al. 2021

Journal of Thrombosis and Haemostasis

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“…Therefore, their association should not be ignored. In addition, infection, especially abdominal inflammation, is one of the most frequently acquired prothrombotic states (2,14). Our patient might have an intra-abdominal infection manifested as digestive symptoms, fever, and elevated inflammatory indexes at admission.…”

Section: Case Reportmentioning

confidence: 86%

Acute mesenteric vein thrombosis after endoscopic injection sclerotherapy for esophageal varices in a patient with liver cirrhosis

Wang

Hou

et al. 2019

DD&T

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Portal vein thrombosis (PVT) is a common complication of liver cirrhosis. The association between endoscopic injection sclerotherapy (EIS) and PVT is unclear. In this paper, we reported that a male cirrhotic patient developed acute mesenteric vein thrombosis after EIS for secondary prophylaxis of esophageal variceal bleeding. Immediate anticoagulation therapy was effective and safe in this patient.

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A Novel Technique of Physiological Portal Inflow Augmentation During Liver Transplantation for Yerdel Grade 4 Portal Vein Thrombosis

Puri¹,

Gunasekaran²,

Palanisamy³

et al. 2019

Liver Transpl

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Natural history and clinical outcomes in patients with portal vein thrombosis by etiology: A retrospective cohort study

Cited by 21 publications

References 13 publications

Incidence and predictors of splanchnic vein thrombosis and mortality following hepatobiliary and pancreatic surgery

Incidence and predictors of splanchnic vein thrombosis and mortality following hepatobiliary and pancreatic surgery

Acute mesenteric vein thrombosis after endoscopic injection sclerotherapy for esophageal varices in a patient with liver cirrhosis

A Novel Technique of Physiological Portal Inflow Augmentation During Liver Transplantation for Yerdel Grade 4 Portal Vein Thrombosis

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