Natural Heterogeneity of Thyroid Cells: The Basis for Understanding Thyroid Function and Nodular Goiter Growth*

Studer, H; Peter, H J; Gerber, H

doi:10.1210/edrv-10-2-125

Cited by 231 publications

(142 citation statements)

References 0 publications

Supporting

Mentioning

115

Contrasting

Unclassified

Order By: Relevance

“…As proposed by Studer et al (27), the above intrinsic stem cell clone model reconciles earlier kinetic observations (36,37) that hyperstimulated thyroid attains a plateau phase of growth or state of "desensitization", with the vast majority of follicular cells becoming refractory to the mitogenic effects of increased TSH levels before the emergence of adenomas. In this model, chronic TSH stimulation would…”

Section: Increased Tsh Stimulationsupporting

confidence: 82%

“…Because of the homogeneity of the growth potential of follicular cells (27), a fraction of these follicular cells in adults would likely turnover much more than five times. It is assumed that cycles of cell division may be more frequent in benign or malignant tumors (27,28), although evidence from human tumors does not always support this notion (29).…”

Section: Cell Biology Of Thyroid Carcinogenesismentioning

confidence: 99%

See 1 more Smart Citation

Relevance of iodine intake as a reputed predisposing factor for thyroid cancer

Knobel

Medeiros‐Neto

2007

Arq Bras Endocrinol Metab

View full text Add to dashboard Cite

Iodine is a trace element that is essential for the synthesis of thyroid hormone. Both chronic iodine deficiency and iodine excess have been associated with hypertrophy and hyperplasia of follicular cells, attributed to excessive secretion of TSH. This may be associated to thyroid cancer risk, particularly in women. Experimental studies have documented thyroid cancer induction by elevation of endogenous TSH, although in a small number of animals. Iodine deficiency associated with carcinogenic agents and chemical mutagens will result in a higher incidence of thyroid malignancy. Inadequate low iodine intake will result in increased TSH stimulation, increased thyroid cell responsiveness to TSH, increased thyroid cell EGF-induced proliferation, decreased TGFβ 1 production and increased angiogenesis, all phenomena related to promotion of tumor growth. Epidemiological studies associating iodine intake and thyroid cancer led to controversial and conflicting results. There is no doubt that introduction of universal iodine prophylaxis in population previously in chronic iodine-deficiency leads to a changing pattern of more prevalent papillary thyroid cancer and declining of follicular thyroid cancer. Also anaplastic thyroid cancer is practically not seen after years of iodine supplementation. Iodine excess has also been indicated as a possible nutritional factor in the prevalence of differentiated thyroid cancer in Iceland, Hawaii and, more recently, in China. In conclusion: available evidence from animal experiments, epidemiological studies and iodine prophylaxis has demonstrated a shift towards a rise in papillary carcinoma, but no clear relationship between overall thyroid cancer incidence and iodine intake.

show abstract

Section: Increased Tsh Stimulationsupporting

confidence: 82%

Section: Cell Biology Of Thyroid Carcinogenesismentioning

confidence: 99%

Relevance of iodine intake as a reputed predisposing factor for thyroid cancer

Knobel

Medeiros‐Neto

2007

Arq Bras Endocrinol Metab

View full text Add to dashboard Cite

show abstract

“…Iodine deficiency is an important factor for the development of autonomy and goiter and with the size of the goiter the probability of autonomy rises (27)(28)(29). It has been found in study of Roti et al (26) that incidence of iodinerelated hyperthyroidism reached to 1.7% in the regions of iodine deficiency while it remained much lower in the regions with adequate iodine.…”

Section: Discussionmentioning

confidence: 98%

Thyroid functions after contrast agent administration for coronary angiography: a prospective observational study in euthyroid patients

Özkan¹,

Semiz-Oysu²,

Kayataş³

et al. 2013

Anadolu Kardiyol Derg

View full text Add to dashboard Cite

Objective: This study aims to investigate long-term effects of iodinated radiographic contrast media used for coronary angiography (CAG) on the thyroid function in euthyroid patients. Methods: In a prospective observational cohort study, nonionic iodinated contrast material was electively used in 101 patients for coronary angiography. The patients were recruited without age restrictions and, at baseline, all had normal levels of free triiodothyronine (FT3), free thyroxine (FT4) and thyrotropin (TSH). The morphology of the thyroid was evaluated by thyroid ultrasonography (USG). Four and eight weeks after CAG, serum TSH, FT3 and FT4 levels were assessed. Results: Compared to a mean baseline level of 1.49 (25%-75%, range 13-2.21), follow-up TSH levels decreased significantly to 1.45 (25%-75%, range 1.98-0.92, p=0.017) and 1.40 (25%-75%, range 1.89-0.87, p=0.003) at 4 weeks and 8 weeks, respectively (p=0.008). No significant diffe-rence was observed in TSH levels between the 4 th and 8 th weeks (p=0.833). Conclusion: Iodinated radiographic contrast agents may cause subclinical hyperthyroidism in euthyroid patients undergoing CAG. (

show abstract

“…The more radical approach is preferable, especially in young patients with long life expectancy because there is an increased probability of recurrent disease in these patients. This concept is based on the exciting findings from several research teams at our institution who described the potentially polynodular growth of multinodular goiter by episodic proliferation of heterogeneous cohorts of epithelial cells from which new follicles are generated [7,8,12,14,15], which means that the capability of nodular growth exists everywhere in the thyroid gland. Nodular growth is dependent on the presence of several growth factors.…”

Section: Discussionmentioning

confidence: 99%

Thyroid Gland Surgery in an Endemic Region

1996

View full text Add to dashboard Cite

Abstract. To assess the incidence, indications, and complications of (reoperative) thyroid gland surgery in an endemic region, we have retrospectively analyzed 1318 patients operated on between 1983 and 1994. There were 166 reoperations (13.5%). In comparison to the primary operation the indication for reoperation showed an increased rate of premalignant and malignant tumors (؉16%) and a decreased rate of hyperthyroid disorders (؊30%). The largest group operated on had benign multinodular goiters, with the same rate of indication for primary (57.4%) and secondary (57.8%) surgery. Permanent recurrent laryngeal nerve palsy rate following primary operation occurred at rates of 1.7% (1983-1990) and 0.7% (1991-1994) and for secondary operation 3.5% (1983-1990) and 5.6% (1991-1994), respectively. The change in recurrent nerve palsy rate in the later years was due to a more extensive resection policy at the primary operation and a more liberal approach to reoperative surgery. The high rate of reoperation for benign goiters (13%) and the new data of goitrogenesis have therefore directed our policy to more extensive resection of the thyroid tissue at the initial operation, increasing the rate of lobectomy from 27% (1982-1990) to > 90% (1991-1994) and at the same time lowering morbidity. Extensive resection of nodular tissue during the initial operation safely reduces the incidence of recurrent goiter and subsequently reduces the rate of reoperation and eliminates the high risk of morbidity associated with reoperative thyroid surgery. The indications for reoperation should be strict, and when unavoidable a modified lateral approach may be helpful.

show abstract

Natural Heterogeneity of Thyroid Cells: The Basis for Understanding Thyroid Function and Nodular Goiter Growth*

Cited by 231 publications

References 0 publications

Relevance of iodine intake as a reputed predisposing factor for thyroid cancer

Relevance of iodine intake as a reputed predisposing factor for thyroid cancer

Thyroid functions after contrast agent administration for coronary angiography: a prospective observational study in euthyroid patients

Thyroid Gland Surgery in an Endemic Region

Contact Info

Product

Resources

About