Natural Herbal Medicine as a Treatment Strategy for Myocardial Infarction through the Regulation of Angiogenesis

Zhang, Mu-xin; Song, Yu; Xu, Weiqing; Zhang, Ling-xiao; Li, Chao; Li, Yunlun

doi:10.1155/2022/8831750

Cited by 7 publications

(5 citation statements)

References 159 publications

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“…Several studies had shown that therapeutic angiogenesis may be an effective strategy for management of ischemic diseases such as MI, particularly for patients who are not eligible for traditional methods of revascularization (Moghiman et al 2021 ; Spadaccio et al 2022 ; Zhang et al 2022 ). This strategy involves restoring perfusion to ischemic regions through stimulation of neovascularization and maturation of preexisting vasculature into functional ones (Moghiman et al 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Enhancement of cardiac angiogenesis in a myocardial infarction rat model using selenium alone and in combination with PTXF: the role of Akt/HIF-1α signaling pathway

Elseweidy,

Ali,

Shaheen

et al. 2023

Naunyn-Schmiedeberg's Arch Pharmacol

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Ischemic heart diseases such as myocardial infarction (MI) are a global health problem and a leading cause of mortality worldwide. Angiogenesis is an important approach for myocardial healing following ischemia. Thus, this study aimed to explore the potential cardiac angiogenic effects of selenium (Se), alone and in combination with the tumor necrosis factor-alpha inhibitor, pentoxifylline (PTXF), via Akt/HIF-1α signaling. MI was induced in rats using two subcutaneous doses of isoprenaline (ISP) at a 24-h interval (150 mg/kg). One week later, rats were orally given Se (150 µg/kg/day), PTXF (50 mg/kg/day), or Se/PTXF combination. ISP-induced myocardial damage was evident by increased HW/TL ratios, ST segment elevation, and increased serum levels of CK-MB, LDH, and troponin-I. ISP increased the cardiac levels of the lipid peroxidation marker MDA; the pro-inflammatory cytokines IL-6, IL-1β, and TNF-α; and the pro-apoptotic protein Bax and caspase-3. In contrast, the cardiac levels of the antioxidant markers GSH and SOD and the anti-apoptotic marker Bcl-2 were reduced. Furthermore, ISP markedly increased the cardiac levels of p-Akt and HIF-1α proteins and the cardiac gene expression of ANGPT-1, VEGF, and FGF-2. Treatment with Se both alone and in combination with PTXF ameliorated the ISP-induced myocardial damage and further increased cardiac angiogenesis via Akt/HIF-1α signaling. Se/PTXF combined therapy was more beneficial than individual treatments. Our study revealed for the first time the cardiac angiogenic effects of Se both alone and in combination with PTXF in myocardial infarction, suggesting that both may be promising candidates for clinical studies. Graphical Abstract

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Section: Discussionmentioning

confidence: 99%

Enhancement of cardiac angiogenesis in a myocardial infarction rat model using selenium alone and in combination with PTXF: the role of Akt/HIF-1α signaling pathway

Elseweidy,

Ali,

Shaheen

et al. 2023

Naunyn-Schmiedeberg's Arch Pharmacol

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“…Extensive clinical evidences supported that blood-activating and stasis-removing drugs provided excellent efficacy in improving microvascular function and clinical prognosis (Fang et al, 2022;Wang et al, 2021; M. X. Zhang et al, 2022). Whitmania pigra Whitman was mostly utilized in the localized venous congestion settings related to flap surgical replantation and reconstructions (Shakouri and Wollina, 2021).…”

Section: Discussionmentioning

confidence: 99%

Chuanzhitongluo capsule ameliorates microcirculatory dysfunction in rats: Efficacy evaluation and metabolic profiles

Sun

Cheng²,

Du³

et al. 2022

Front. Pharmacol.

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Background: Ischemic stroke is a leading cause of mortality and disability worldwide. Microcirculatory dysfunction is the foremost hindrance for a good clinical prognosis in ischemic stroke patients. Clinical researches show that Chuanzhitongluo capsule (CZTL) has a curative effect during the recovery period of ischemic stroke, which contributes to a good prognosis. However, it is not known whether CZTL treats ischemic stroke by ameliorating microcirculation dysfunction.Objective: In this study, we investigated the influence of CZTL on microcirculation and its underlying mechanism.Methods: A rat model of acute microcirculatory dysfunction was established by stimuli of adrenaline and ice water. The microcirculatory damage in model rats and the efficacy of CZTL were assessed by detecting laser speckle contrast imaging, coagulation function, hemorheology, vasomotor factor and microcirculation function. The potential mechanism of CZTL action was explored by the untargeted metabolomic analysis based on ultra-performance liquid chromatography-quadrupole-time of flight-mass spectrometry.Results: Laser speckle contrast imaging showed that model rats suffered low perfusion in ears, feet and tails, and CZTL treatment increased microcirculatory blood flow. Coagulation function detection results showed that CZTL diminished the reduction of thrombin time, prothrombin time, activated partial thromboplastin time and the elevated fibrinogen level caused by acute microcirculatory dysfunction. Furthermore, CZTL could recover the increased blood viscosity as well as the abnormal vasomotor and microcirculation function in rats with acute microcirculatory dysfunction. Metabolomics analysis indicated that CZTL might regulate sphingolipid metabolism and arachidonic acid metabolism to exert protective effects on microcirculation.Conclusion: These results elucidated that CZTL was highly effective against microcirculatory dysfunction and its potential mechanisms related with the modulation of sphingolipid and arachidonic acid metabolic pathways. The present study provided a new perspective on the clinical application of CZTL, and it contribute to explore novel therapeutic drug against microcirculatory dysfunction.

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“…Tanshinone, a lipophilic compound of Danshen, has been classified into four types based on its structural diversity: tanshinone IIA, cryptotanshinone, tanshinone I (Tan I), and dihydroisotanshinone I (DT) [ 18 ]. In clinical practice, Danshen is used for the treatment of various diseases, including cardiovascular diseases [ 19 ], cerebrovascular diseases [ 18 , 20 ], Alzheimer’s disease [ 21 ], PD [ 22 ], and renal injury [ 23 ]. Danshen is widely used for the treatment of cardiovascular disorders and its aqueous extract has shown anticancer as well as antioxidant effects [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

“…In clinical practice, Danshen is used for the treatment of various diseases, including cardiovascular diseases [ 19 ], cerebrovascular diseases [ 18 , 20 ], Alzheimer’s disease [ 21 ], PD [ 22 ], and renal injury [ 23 ]. Danshen is widely used for the treatment of cardiovascular disorders and its aqueous extract has shown anticancer as well as antioxidant effects [ 19 ]. Moreover, Danshen has been widely used in the treatment of central nervous system diseases.…”

Section: Introductionmentioning

confidence: 99%

Dihydroisotanshinone I and BMAL-SIRT1 Pathway in an In Vitro 6-OHDA-Induced Model of Parkinson’s Disease

Sun

Yang

et al. 2023

IJMS

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Danshen has been widely used for the treatment of central nervous system diseases. We investigated the effect of dihydroisotanshinone I (DT), a compound extracted from Danshen, as well as the corresponding mechanisms in an in vitro-based 6-OHDA-induced Parkinson’s disease (PD) model. SH-SY5Y human neuroblastoma cell lines were pretreated with 6-hydroxydopamine (6-OHDA) and challenged with DT. Subsequently, the cell viability and levels of reactive oxygen species (ROS) and caspase-3 were analyzed. The effect of DT on the 6-OHDA-treated SH-SY5Y cells and the expression of the core circadian clock genes were measured using a real-time quantitative polymerase chain reaction. Our results indicated that DT attenuated the 6-OHDA-induced cell death in the SH-SY5Y cells and suppressed ROS and caspase-3. Moreover, DT reversed both the RNA and protein levels of BMAL1 and SIRT1 in the 6-OHDA-treated SH-SY5Y cells. Additionally, the SIRT1 inhibitor attenuated the effect of DT on BMAL1 and reduced the cell viability. The DT and SIRT1 activators activated SIRT1 and BMAL1, and then reduced the death of the SH-SY5Y cells damaged by 6-OHDA. SIRT1 silencing was enhanced by DT and resulted in a BMAL1 downregulation and a reduction in cell viability. In conclusion, our investigation suggested that DT reduces cell apoptosis, including an antioxidative effect due to a reduction in ROS, and regulates the circadian genes by enhancing SIRT1 and suppressing BMAL1. DT may possess novel therapeutic potential for PD in the future, but further in vivo studies are still needed.

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Natural Herbal Medicine as a Treatment Strategy for Myocardial Infarction through the Regulation of Angiogenesis

Cited by 7 publications

References 159 publications

Enhancement of cardiac angiogenesis in a myocardial infarction rat model using selenium alone and in combination with PTXF: the role of Akt/HIF-1α signaling pathway

Enhancement of cardiac angiogenesis in a myocardial infarction rat model using selenium alone and in combination with PTXF: the role of Akt/HIF-1α signaling pathway

Chuanzhitongluo capsule ameliorates microcirculatory dysfunction in rats: Efficacy evaluation and metabolic profiles

Dihydroisotanshinone I and BMAL-SIRT1 Pathway in an In Vitro 6-OHDA-Induced Model of Parkinson’s Disease

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