Natural halloysite nanotubes as mesoporous carriers for the loading of ibuprofen

Tan, Daoyong; Yuan, Peng; Annabi-Bergaya, Faïza; Yu, Huaguang; Liu, Dong; Li, Hongmei; He, Hongping

doi:10.1016/j.micromeso.2013.05.007

Cited by 140 publications

(76 citation statements)

References 68 publications

(93 reference statements)

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“…The electrostatic attraction was stronger than the hydrogen bonding in the case of IBU loading in unmodified halloysite. 71 The release of IBU from the APTES-modified and pristine HNT fits with the modified Korsmeyer-Peppas model. † The strong affinity (electrostatic attraction) in APTES-modified HNT slowed the release of IBU and changed the release mechanism from Fickian diffusion in the pristine HNT to non-Fickian diffusion in the APTES-HNT.…”

Section: Application Of Modified Hnts As Drug Carrier and Delivery Symentioning

confidence: 99%

Covalently modified halloysite clay nanotubes: synthesis, properties, biological and medical applications

et al. 2017

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a Halloysite (HNT) is a promising natural nanosized tubular clay mineral that has many important uses in different industrial fields. It is naturally occurring, biocompatible, and available in thousands of tons at low cost. As a consequence of a hollow cavity, HNT is mainly used as nanocontainer for the controlled release of several chemicals. Chemical modification of both surfaces (inner lumen and outer surface) is a strategy to tune the nanotube's properties. Specifically, chemical modification of HNT surfaces generates a nanoarchitecture with targeted affinity through outer surface functionalization and drug transport ability from functionalization of the nanotube lumen. The primary focus of this review is the research of modified halloysite nanotubes and their applications in biological and medical fields.

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Section: Application Of Modified Hnts As Drug Carrier and Delivery Symentioning

confidence: 99%

Covalently modified halloysite clay nanotubes: synthesis, properties, biological and medical applications

et al. 2017

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“…This wrapping is driven by a mismatch between the oxygen-sharing tetrahedral SiO 4 sheet and its adjacent octahedral A1O 6 sheet in the 1:1 layer (Bates et al, 1950;Singh, 1996). Because of its unique onedimensional mesoscopic/macroscopic porous structure and economic viability, halloysite has been applied as a nanoscale reactor (Shchukin et al, 2005), as a nanofiller for CPN (Hedicke-Hochstotter et al, 2009;Li et al, 2008a), and as a carrier or support for the entrapment and controlled release of functional guests (Levis and Deasy, 2002;Lvov et al, 2008;Tan et al, 2013;Yuan et al, 2012a). It is worth emphasizing that halloysite has a high level of biocompatibility and low cytotoxicity, which enables its safe use in various fields (Van Oss et al, 1999;Vergaro et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

From platy kaolinite to aluminosilicate nanoroll via one-step delamination of kaolinite: Effect of the temperature of intercalation

Yuan

Tan

Annabi-Bergaya

et al. 2013

Applied Clay Science

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125

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“…Furthermore, the modified HNTs have a long time sustaining release reached to 115 h. In addition, the functionlization HNTs crosslink with the APTES used to load ibuprofen [40], for low loading capacity and burst release for HNTs. The date showed that the modified HNTs possess higher capacity to load ibuprofen increasing by 25.4% [41]. The release of ibuprofen indicated that the modified and unmodified HNTs put up a two-step release in vitro.…”

Section: As the Nanocarriers For Drug Deliverymentioning

confidence: 98%

Recent Advances on Surface Modification of Halloysite Nanotubes for Multifunctional Applications

Yang¹,

Chen²,

Fan³

et al. 2017

Preprint

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Halloysite nanotubes (HNTs) are natural occurring mineral clay nanotubes that have excellent application potential in different fields. However, HNTs are affected by size effect, surface electron effect and hydrogen bond formation on the surface which lead to weak affinity and prone to reunion at some extent. It is very significant to modify the HNTs' surface for expand its applications. In this review, the structural characteristics, performance and the related applications of surface modification HNTs are reviewed and summarized. we focus on the surface modified methods of HNTs, the effect of surface modification on materials and its related applications in various regions. In addition, future prospects and the meaning of surface modification have been discussed in HNTs studies. This review provided a reference for the application of HNTs modifications in new fields.

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Natural halloysite nanotubes as mesoporous carriers for the loading of ibuprofen

Cited by 140 publications

References 68 publications

Covalently modified halloysite clay nanotubes: synthesis, properties, biological and medical applications

Covalently modified halloysite clay nanotubes: synthesis, properties, biological and medical applications

From platy kaolinite to aluminosilicate nanoroll via one-step delamination of kaolinite: Effect of the temperature of intercalation

Recent Advances on Surface Modification of Halloysite Nanotubes for Multifunctional Applications

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