Natural glycyrrhizic acid-tailored hydrogel with in-situ gradient reduction of AgNPs layer as high-performance, multi-functional, sustainable flexible sensors

Zhang, Hao; Tang, Nan; Yu, Xia; Guo, Zhongkai; Liu, Zhen; Sun, Xiaoming; Li, Min-Hui; Hu, Jun

doi:10.1016/j.cej.2021.132779

Cited by 28 publications

(34 citation statements)

References 62 publications

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“…[43] GA is a natural compound obtained from the liquorice plant, known for its antiinflammatory effects. [44] We predicted that the antiinflammatory effect of GA is related to macrophage phe notypes regulation and wound microenvironment modulation. In order to test this hypothesis, FITCphalloidin stained Factin was employed to assess changes in macrophage morphology after 48h cultured on the hydrogels.…”

Section: In Vitro Immune Regulation Of the Hybrid Hydrogelmentioning

confidence: 99%

Immunoregulation in Diabetic Wound Repair with a Photoenhanced Glycyrrhizic Acid Hydrogel Scaffold

et al. 2022

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M1 macrophage accumulation and excessive inflammation are commonly encountered issues in diabetic wounds and can fail in the healing process. Hence, hydrogel dressings with immunoregulatory capacity have great promise in the clinical practice of diabetic wound healing. However, current immunoregulatory hydrogels are always needed for complex interventions and high‐cost treatments, such as cytokines and cell therapies. In this study, a novel glycyrrhizic acid (GA)‐based hybrid hydrogel dressing with intrinsic immunoregulatory properties is developed to promote rapid diabetic wound healing. This hybrid hydrogel consists of interpenetrating polymer networks composed of inorganic Zn2+‐induced self‐assembled GA and photo‐crosslinked methyl acrylated silk fibroin (SF), realizing both excellent injectability and mechanical strength. Notably, the SF/GA/Zn hybrid hydrogel can regulate macrophage responses in the inflammatory microenvironment, circumventing the use of any additives. The immunomodulatory properties of the hydrogel can be harnessed for safe and efficient therapeutics that accelerate the three phases of wound repair and serve as a promising dressing for the management of diabetic wounds.

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Section: In Vitro Immune Regulation Of the Hybrid Hydrogelmentioning

confidence: 99%

Immunoregulation in Diabetic Wound Repair with a Photoenhanced Glycyrrhizic Acid Hydrogel Scaffold

et al. 2022

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“…The introduction of dynamic and reversible noncovalent interactions, including coordination bonds, ionic bonds, host-guest interaction and hydrogen bonds, could endow a hydrogel with a self-healing ability, as well as stimuli-responsive and adaptive properties ( Cao et al, 2018 ; Huang et al, 2018 ; Yan et al, 2020 ). Among the wide ranges of noncovalent bonds, hydrogen bonds are commonly found in natural systems, due to their bonding strength and low toxicity, and have been widely used to design functional hydrogels ( Chen et al, 2016 ; Zhang et al, 2022 ). Moreover, the hydrogen bonds in a hydrogel serve as sacrificial bonds and show an excellent toughening effect, by effectively dissipating external energy ( Zhang et al, 2018 ).…”

Section: Introductionmentioning

confidence: 99%

A Hydrogen Bonds-Crosslinked Hydrogels With Self-Healing and Adhesive Properties for Hemostatic

Xiao

et al. 2022

Front. Bioeng. Biotechnol.

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Hydrogels with adhesive properties have the potential for rapid haemostasis and wound healing in uncontrolled non-pressurized surface bleeding. Herein, a typical hydrogen bond-crosslinked hydrogel with the above functions was constructed by directly mixing solutions of humic acid (HA) and polyvinylpyrrolidone (PVP), in which the HA worked as a crosslinking agent to form hydrogen bonds with the PVP. By altering the concentration of HA, a cluster of stable and uniform hydrogels were prepared within 10 s. The dynamic and reversible nature of the hydrogen bonds gave the HA/PVP complex (HPC) hydrogels injectability and good flexibility, as well as a self-healing ability. Moreover, the numerous functional groups in the hydrogels enhanced the cohesion strength and interaction on the interface between the hydrogel and the substrate, endowing them with good adhesion properties. The unique chemical composition and cross-linking mechanism gave the HPC hydrogel good biocompatibility. Taking advantage of all these features, the HPC hydrogels obtained in this work were broadly applied as haemostatic agents and showed a good therapeutic effect. This work might lead to an improvement in the development of multifunctional non-covalent hydrogels for application to biomaterials.

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“…[1][2][3][4][5] Wearable strain sensors convert physiological signals into electrical signals, which can be used to detect physiological activities and types of motor behavior, such as the pulse, respiratory rate, speech recognition, and the bending of joints. Therefore, flexible strain sensors show great application potential in the fields of clinical diagnosis, 6,7 medical health, 8,9 human-computer interactions, 10,11 electronic skin 12,13 and industrial robots. 14,15 The vast majority of traditional strain electronic sensor devices are composed of metal and semiconductor materials, which are limited by the tensile properties and flexibility of the materials themselves, such that it is difficult to meet the requirements of wearable devices and are therefore not suitable for the detection of human motion.…”

Section: Introductionmentioning

confidence: 99%

A flexible wearable strain sensor for human-motion detection and a human–machine interface

Zhang

Guan

et al. 2022

J. Mater. Chem. C

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Natural glycyrrhizic acid-tailored hydrogel with in-situ gradient reduction of AgNPs layer as high-performance, multi-functional, sustainable flexible sensors

Cited by 28 publications

References 62 publications

Immunoregulation in Diabetic Wound Repair with a Photoenhanced Glycyrrhizic Acid Hydrogel Scaffold

Immunoregulation in Diabetic Wound Repair with a Photoenhanced Glycyrrhizic Acid Hydrogel Scaffold

A Hydrogen Bonds-Crosslinked Hydrogels With Self-Healing and Adhesive Properties for Hemostatic

A flexible wearable strain sensor for human-motion detection and a human–machine interface

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