Natural fruits, flowers, honey, and honeybees harbor<i>Helicobacter pylori</i>‐positive yeasts

Siavoshi, Farideh; Sahraee, Marzieh; Ebrahimi, Hoda; Sarrafnejad, Abdolfattah; Saniee, Parastoo

doi:10.1111/hel.12471

Cited by 24 publications

(24 citation statements)

References 89 publications

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“…In the absence of urea, this bacterium cannot raise the environmental pH and must seek other strategies to protect itself from stressors, such as its ability to invade and remain viable within eukaryotic cells. H. pylori has been reported not only to invade and survive within human cells, but also within free-living amoebas and yeasts isolated from the mouth of adults and newborns, as well as the vagina, yogurt, honey, and other environmental sources [2,19,[32][33][34] The results of these studies suggest that eukaryotic organisms might protect H. pylori and be a transmission vehicle for this bacterium. In addition, C. albicans has a wide range of tolerance to pH, which was confirmed in this study: the C. albicans ATCC 90028 strain was not affected by the acidic pH values assayed (Figure 2), not reaching the stationary phase even after 50 h of incubation.…”

Section: Discussionmentioning

confidence: 90%

In Vitro Incorporation of Helicobacter pylori into Candida albicans Caused by Acidic pH Stress

et al. 2020

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Yeasts can adapt to a wide range of pH fluctuations (2 to 10), while Helicobacter pylori, a facultative intracellular bacterium, can adapt to a range from pH 6 to 8. This work analyzed if H. pylori J99 can protect itself from acidic pH by entering into Candida albicans ATCC 90028. Growth curves were determined for H. pylori and C. albicans at pH 3, 4, and 7. Both microorganisms were co-incubated at the same pH values, and the presence of intra-yeast bacteria was evaluated. Intra-yeast bacteria-like bodies were detected using wet mounting, and intra-yeast binding of anti-H. pylori antibodies was detected using immunofluorescence. The presence of the H. pylori rDNA 16S gene in total DNA from yeasts was demonstrated after PCR amplification. H. pylori showed larger death percentages at pH 3 and 4 than at pH 7. On the contrary, the viability of the yeast was not affected by any of the pHs evaluated. H. pylori entered into C. albicans at all the pH values assayed but to a greater extent at unfavorable pH values (pH 3 or 4, p = 0.014 and p = 0.001, respectively). In conclusion, it is possible to suggest that H. pylori can shelter itself within C. albicans under unfavorable pH conditions.

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Section: Discussionmentioning

confidence: 90%

In Vitro Incorporation of Helicobacter pylori into Candida albicans Caused by Acidic pH Stress

et al. 2020

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“…Another study related to environmental H. pylori reservoirs was reported from Iran. Siavoshi et al studied yeast isolates for the intracellular occurrence of H. pylori . Yeasts were isolated from 29 samples, including oral swabs from villagers (n = 7), flowers and fruits (n = 6), honey and honeybees (n = 12) and miscellaneous samples (n = 4).…”

Section: Factors Associated With Helicobacter Pylori Infectionmentioning

confidence: 99%

Epidemiology of Helicobacter pylori infection

et al. 2018

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This review provides the most recent data concerning the epidemiology of Helicobacter pylori infection. Overall, the trend of declining prevalence of H. pylori infection is continuing, with major evidence available from studies in Europe. However, in some parts of the world, for example, in some countries in the Middle East, the prevalence has remained relatively stable. A number of systematic reviews and meta-analyses have been published during the past year indicating the lowest prevalence rates of the infection in Oceania (24.4%), the highest in Africa (79.1%), and the global annual recurrence rate of H. pylori (4.3%). The recurrence rates were found to be directly related to the human development index and prevalence of infection. Several studies have addressed the correlation between H. pylori infection and sociodemographic conditions, source of drinking water and dietary factors. A hypothesis on the role of insects and yeasts in transmitting H. pylori has been suggested and addressed. Helicobacter sp. have been found in flow flies in Brazil. So far there is no evidence available that H. pylori may survive and persist on the outer body of the fly.

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“…Similarly, bees only accidentally bear S. cerevisiae, with only 1 occurrence over 21 reported cases (Sandhu and Waraich, 1985;Lachance et al, 2003;Rosa et al, 2003;Daniel et al, 2013;Charron et al, 2014;Saksinchai et al, 2015). Conversely, S. cerevisiae has been found in a large portion of investigated flies, fruit flies, honey-bees, and wasps (29, 57, 20, and 71%, respectively) (Phaff and Knapp, 1956;Batra et al, 1973;Sandhu and Waraich, 1985;Morais et al, 1993Morais et al, , 1994Rosa et al, 1994;Lachance et al, 1995Lachance et al, , 2003Lachance et al, , 2006Suh et al, 2005;Nguyen et al, 2006Nguyen et al, , 2007Basukriadi et al, 2010;Goddard et al, 2010;Chandler et al, 2012;de Vega et al, 2012;Hamby et al, 2012;Stefanini et al, 2012;Freitas et al, 2013;Buser et al, 2014;Charron et al, 2014;Lam and Howell, 2015;Saksinchai et al, 2015;Batista et al, 2017;Deutscher et al, 2017;Jimenez et al, 2017;Piper et al, 2017;Quan and Eisen, 2018;Siavoshi et al, 2018;dos Santos et al, 2019;Meriggi et al, 2019;…”

Section: Biogeography and Diffusionmentioning

confidence: 99%

Saccharomyces cerevisiae – Insects Association: Impacts, Biogeography, and Extent

et al. 2020

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Over the last few years, an increasing number of studies have reported the existence of an association between the budding yeast Saccharomyces cerevisiae and insects. The discovery of this relationship has called into question the hypothesis that S. cerevisiae is unable to survive in nature and that the presence of S. cerevisiae strains in natural specimens is the result of contamination from human-related environments. S. cerevisiae cells benefit from this association as they find in the insect intestine a shelter, but also a place where they can reproduce themselves through mating, the latter being an event otherwise rarely observed in natural environments. On the other hand, insects also take advantage in hosting S. cerevisiae as they rely on yeasts as nutriment to properly develop, to localize suitable food, and to enhance their immune system. Despite the relevance of this relationship on both yeast and insect ecology, we are still far from completely appreciating its extent and effects. It has been shown that other yeasts are able to colonize only one or a few insect species. Is it the same for S. cerevisiae cells or is this yeast able to associate with any insect? Similarly, is this association geographically or topographically limited in areas characterized by specific physical features? With this review, we recapitulate the nature of the S. cerevisiaeinsect association, disclose its extent in terms of geographical distribution and species involved, and present YeastFinder, a cured online database providing a collection of information on this topic.

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Natural fruits, flowers, honey, and honeybees harborHelicobacter pylori‐positive yeasts

Cited by 24 publications

References 89 publications

In Vitro Incorporation of Helicobacter pylori into Candida albicans Caused by Acidic pH Stress

In Vitro Incorporation of Helicobacter pylori into Candida albicans Caused by Acidic pH Stress

Epidemiology of Helicobacter pylori infection

Saccharomyces cerevisiae – Insects Association: Impacts, Biogeography, and Extent

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