Natural food science based novel approach toward prevention and treatment of obesity and type 2 diabetes: Recent studies on brown rice and γ-oryzanol

Kozuka, Chisayo; Yabiku, Kouichi; Takayama, Chitoshi; Matsushita, Masayuki; Shimabukuro, Michio; Masuzaki, Hiroaki

doi:10.1016/j.orcp.2013.02.003

Cited by 73 publications

(59 citation statements)

References 64 publications

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“…Although g-oryzanol has a wide variety of beneficially metabolic effects (Kozuka et al, 2012;Kozuka et al, 2013;Kozuka et al, 2015a, Kozuka et al, 2015b, extremely low absorption efficiency from intestine of g-oryzanol is a tough obstacle for the clinical application. Gamma-oryzanol ameliorates preference for animal fat and fuel metabolism in HFD-fed mice (Kozuka et al, 2012(Kozuka et al, , 2013(Kozuka et al, , 2015a(Kozuka et al, , 2015b. However, in ob/ob mice, the bestknown severest diabetic model in mice, g-oryzanol actually shows no apparent effect on metabolic amelioration.…”

Section: Discussionmentioning

confidence: 99%

Marked augmentation of PLGA nanoparticle-induced metabolically beneficial impact of γ-oryzanol on fuel dyshomeostasis in genetically obese-diabetic ob/ob mice

et al. 2017

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Our previous works demonstrated that brown rice-specific bioactive substance, g-oryzanol acts as a chaperone, attenuates exaggerated endoplasmic reticulum (ER) stress in brain hypothalamus and pancreatic islets, thereby ameliorating metabolic derangement in high fat diet (HFD)-induced obese diabetic mice. However, extremely low absorption efficiency from intestine of g-oryzanol is a tough obstacle for the clinical application. Therefore, in this study, to overcome extremely low bioavailability of g-oryzanol with super-high lipophilicity, we encapsulated g-oryzanol in polymer poly (DL-lactide-co-glycolide) (PLGA) nanoparticles (Nano-Orz), and evaluated its metabolically beneficial impact in genetically obese-diabetic ob/ob mice, the bestknown severest diabetic model in mice. To our surprise, Nano-Orz markedly ameliorated fuel metabolism with an unexpected magnitude ($1000-fold lower dose) compared with regular g-oryzanol. Furthermore, such a conspicuous impact was achievable by its administration once every 2 weeks. Besides the excellent impact on dysfunction of hypothalamus and pancreatic islets, Nano-Orz markedly decreased ER stress and inflammation in liver and adipose tissue. Collectively, nanotechnology-based developments of functional foods oriented toward g-oryzanol shed light on the novel approach for the treatment of a variety of metabolic diseases in humans.

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Section: Discussionmentioning

confidence: 99%

Marked augmentation of PLGA nanoparticle-induced metabolically beneficial impact of γ-oryzanol on fuel dyshomeostasis in genetically obese-diabetic ob/ob mice

et al. 2017

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“…It has been previously shown that cooked ordinary rice could prevent hyperlipidemia in high fat-fed hamsters through regulation of hepatic genes involved in lipid metabolism [22]. Recent studies also revealed that brown rice could prevent obesity and diabetes in humans [23]. Lee et al reported that compared with the conventional brown rice, the giant embryonic brown rice significantly increased the HDL-cholesterol concentrations and reduced the atherosclerosis cardiovascular disease risk in rats fed with high cholesterol diet [24].…”

Section: Discussionmentioning

confidence: 99%

Effect of Instant Cooked Giant Embryonic Rice on Body Fat Weight and Plasma Lipid Profile in High Fat-Fed Mice

et al. 2014

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The comparative effects of instant cooked rice made from giant embryo mutant or ordinary normal rice on body weight and lipid profile in high fat-fed mice were investigated. The animals were given experimental diets for seven weeks: normal control (NC), high fat (HF), and HF supplemented with instant normal white (HF-NW), normal brown (HF-NB), giant embryonic white (HF-GW), or giant embryonic brown (HF-GB) rice. The HF group showed markedly higher body weight, body fat, plasma and hepatic triglyceride and cholesterol concentrations, and atherogenic index relative to NC group. However, instant rice supplementation counteracted this high fat-induced hyperlipidemia through regulation of lipogenesis and adipokine production. The GB rice exhibited greater hypolipidemic and body fat-lowering effects than the GW or NB rice. These findings illustrate that the giant embryo mutant may be useful as functional biomaterial for the development of instant rice with strong preventive action against high fat diet-induced hyperlipidemia and obesity.

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“…A great variety of biological effects has been attributed to Orz, such as antidiabetic [16], antioxidant [1,17], and anti-inflammatory activities [18]. However, until recently, the most studied Orz-related activities include its hypolipidemic and anti-obesity effects [15,16,19,20]. These potential health benefits are mainly verified through the introduction of a diet high in BR or germinated BR (GBR).…”

Section: Introductionmentioning

confidence: 99%

Antioxidant Activity of γ-Oryzanol: A Complex Network of Interactions

Minatel

Francisqueti

Corrêa

et al. 2016

IJMS

111

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γ-oryzanol (Orz), a steryl ferulate extracted from rice bran layer, exerts a wide spectrum of biological activities. In addition to its antioxidant activity, Orz is often associated with cholesterol-lowering, anti-inflammatory, anti-cancer and anti-diabetic effects. In recent years, the usefulness of Orz has been studied for the treatment of metabolic diseases, as it acts to ameliorate insulin activity, cholesterol metabolism, and associated chronic inflammation. Previous studies have shown the direct action of Orz when downregulating the expression of genes that encode proteins related to adiposity (CCAAT/enhancer binding proteins (C/EBPs)), inflammatory responses (nuclear factor kappa-B (NF-κB)), and metabolic syndrome (peroxisome proliferator-activated receptors (PPARs)). It is likely that this wide range of beneficial activities results from a complex network of interactions and signals triggered, and/or inhibited by its antioxidant properties. This review focuses on the significance of Orz in metabolic disorders, which feature remarkable oxidative imbalance, such as impaired glucose metabolism, obesity, and inflammation.

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Natural food science based novel approach toward prevention and treatment of obesity and type 2 diabetes: Recent studies on brown rice and γ-oryzanol

Cited by 73 publications

References 64 publications

Marked augmentation of PLGA nanoparticle-induced metabolically beneficial impact of γ-oryzanol on fuel dyshomeostasis in genetically obese-diabetic ob/ob mice

Marked augmentation of PLGA nanoparticle-induced metabolically beneficial impact of γ-oryzanol on fuel dyshomeostasis in genetically obese-diabetic ob/ob mice

Effect of Instant Cooked Giant Embryonic Rice on Body Fat Weight and Plasma Lipid Profile in High Fat-Fed Mice

Antioxidant Activity of γ-Oryzanol: A Complex Network of Interactions

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