Natural flavonoids as promising lactate dehydrogenase A inhibitors: Comprehensive in vitro and in silico analysis
Ümit Yırtıcı
Abstract:The inhibitory potential of 17 flavonoids on lactate dehydrogenase A (LDHA), a key enzyme in the downstream process of aerobic glycolysis in cancer cells, is investigated. Fisetin exhibited excellent inhibitory activity (IC50 = 0.066 µM). Quercetin 3‐β‐D‐glucoside, quercetin 3‐galactoside, luteolin, neoeriocitrin, and luteolin 7‐O‐β‐D‐glucoside showed good inhibitory activity (IC50 = 1.397–15.730 µM). Biochanin A, baicalein, quercetin, scutellarein‐7‐glucuronide, diosmetin, baicalein 7‐O‐β‐D‐glucuronide, and a… Show more
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