Natural evolution from macular retinoschisis to full-thickness macular hole in highly myopic eyes

Sun, Chuan-bin; Liu, Z; Xue, Anquan; Yao, Ke

doi:10.1038/eye.2010.123

Cited by 69 publications

(53 citation statements)

References 19 publications

(25 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Previous research indicates that an average duration of 2 years is expected for the progression of LMH to FTMH in high myopic eyes. 15 In the present study, the average duration of LMH to FTMH in six cases was about 13 months, but the variation of duration regarding the progression from LMH to MH was quite large.…”

Section: Discussionmentioning

confidence: 92%

“…15 An FTMH would follow if preretinal traction induces inner laminar dehiscence. In such cases, the MH is associated with macular detachment.…”

Section: Discussionmentioning

confidence: 99%

“…Foveoschisis is believed to be one of the main causes of MH formation in highly myopic eyes, [12][13][14] and is often found in combination with foveal detachment, lamellar MH (LMH), and vitreomacular traction. Although the development of MH from schisis with foveal detachment has been reported, 15 the development of MH through other pathways and the evolution of MH after its formation have not yet been described in detail. In this study, by examining sequential OCT images, we investigated the various mechanisms of the formation of MH and the possible alterations of the retinal structure after MH development in high myopic patients.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The development and evolution of full thickness macular hole in highly myopic eyes

Yang

2015

Eye

View full text Add to dashboard Cite

Purpose To evaluate the morphological changes before and after the formation of a full-thickness macular hole (MH) in highly myopic eyes. Patients and methods Retrospective observational case series. From 2006 to 2013, clinical records of patients with MH and high myopia who had optical coherence tomography (OCT) before the development of MH were reviewed. All patients had been followed for more than 1 year since MH formation to observe the morphological changes.Results Twenty-six eyes of 24 patients were enrolled. The initial OCT images could be classified into four types: (1) normal foveal depression with abnormal vitreo-retinal relationship (eight cases), (2) macular schisis without detachment (six cases), (3) macular schisis with concomitant/subsequent detachment (nine cases), and (4) macular atrophy with underlying/adjacent scar (three cases). After MH formation, one case in type 1 and one case in type 4 group developed retinal detachment (RD). In type 2 group, four cases developed RD at the same time of MH formation. The preexisting detachment in type 3 group extended in eight cases and improved in one case. Among all the cases, 14 eyes received vitrectomy and 7 eyes received gas injection. MH sealed in nine eyes after vitrectomy and four eyes by gas injection. Conclusion The study revealed four pathways of MH formation in highly myopic eyes. MH from macular schisis tended to be associated with detachment. However, the evolution and the results of surgical intervention were not always predictable.

show abstract

Section: Discussionmentioning

confidence: 92%

“…15 An FTMH would follow if preretinal traction induces inner laminar dehiscence. In such cases, the MH is associated with macular detachment.…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The development and evolution of full thickness macular hole in highly myopic eyes

Yang

2015

Eye

View full text Add to dashboard Cite

show abstract

“…The medical data reviewed included colour fundus photography and OCT of 2365 highly myopic patients (age from 3 to 70 years). High myopia was defined as manifest refraction ≤−6 diopters and axial length ≥26 mm2122. Based on the diagnostic criteria of macular retinoschisis in highly myopic eyes reported before122, MRS was determined in 228 cases according to its typical appearance in OCT examination, of whom 9 cases (13 eyes) were under 20 years of age.…”

Section: Methodsmentioning

confidence: 99%

Myopic Macular Retinoschisis in Teenagers: Clinical Characteristics and Spectral Domain Optical Coherence Tomography Findings

Sun

You

Zhe

et al. 2016

Sci Rep

View full text Add to dashboard Cite

To investigate the morphological characteristics of myopic macular retinoschisis (MRS) in teenagers with high myopia, six male (9 eyes) and 3 female (4 eyes) teenagers with typical MRS identified from chart review were evaluated. All cases underwent complete ophthalmic examinations including best corrected visual acuity (BCVA), indirect ophthalmoscopy, colour fundus photography, B-type ultrasonography, axial length measurement, and spectral-domain optical coherence tomography (SD-OCT). The average age was 17.8 ± 1.5 years, average refractive error was −17.04 ± 3.04D, average BCVA was 0.43 ± 0.61, and average axial length was 30.42 ± 1.71 mm. Myopic macular degenerative changes (MDC) by colour fundus photographs revealed Ohno-Matsui Category 1 in 4 eyes, and Category 2 in 9 eyes. Posterior staphyloma was found in 9 eyes. SD-OCT showed outer MRS in all 13 eyes, internal limiting membrane detachment in 7 eyes, vascular microfolds in 2 eyes, and inner MRS in 1 eye. No premacular structures such as macular epiretinal membrane or partially detached posterior hyaloids were found. Our results showed that MRS rarely occurred in highly myopic teenagers, and was not accompanied by premacular structures, severe MDC, or even obvious posterior staphyloma. This finding indicates that posterior scleral expansion is probably the main cause of MRS.

show abstract

“…,35 Sun et al36 observed that two types of MH evolved after MF, based on whether an outer lamellar MH developed. In our study, no MF was found in most of the highly myopic eyes with MH, which indicates that most of the high-myopia MH may have the similar pathogenic mechanisms as idiopathic MH.…”

mentioning

confidence: 98%

Macular Hole Repair by Vitrectomy and Internal Limiting Membrane Peeling in Highly Myopic Eyes

Chuang

Chen

Wang

et al. 2014

Retina

View full text Add to dashboard Cite

Vitrectomy with internal limiting membrane peeling is effective to repair MH in highly myopic eyes in terms of anatomical and functional outcomes, although visual acuity may continue to improve slowly until 3 years after successful MH-closing surgery. In addition, a small proportion of MH cases were associated with myopic foveoschisis. Delayed hole closure and rhegmatogenous retinal detachment may occur in these highly myopic eyes after surgery.

show abstract

Natural evolution from macular retinoschisis to full-thickness macular hole in highly myopic eyes

Abstract: our longitudinal study revealed two patterns of FTMH formation in highly myopic eyes with MRS. This finding might be useful in further understanding the pathogenesis of macular hole formation in high myopia.

Cited by 69 publications

References 19 publications

The development and evolution of full thickness macular hole in highly myopic eyes

The development and evolution of full thickness macular hole in highly myopic eyes

Myopic Macular Retinoschisis in Teenagers: Clinical Characteristics and Spectral Domain Optical Coherence Tomography Findings

Macular Hole Repair by Vitrectomy and Internal Limiting Membrane Peeling in Highly Myopic Eyes

Contact Info

Product

Resources

About