2023
DOI: 10.3390/ijms241814255
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Natural, Designed and Engineered Metalloenzymes: Structure, Catalytic Mechanisms and Applications

Linda Leone,
Flavia Nastri,
Angela Lombardi

Abstract: Bioinorganic chemists have become engaged in the challenge of elucidating the molecular mechanisms that govern how protein scaffolds modulate the properties of metal cofactors [...]

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“…Most importantly, MBP contains bound zinc ions, followed by iron, calcium, and copper. Likewise, metalloproteins and metalloenzymes are a widespread class of specific or superfamily of enzymes found in all cells that possess metal ions as cofactors and catalyze a plethora of reactions, such as oxidation, reduction, biosynthesis, and hormone metabolism, for candidate biological pathways ( Dubey et al, 2021 ; Leone et al, 2023 ).…”
Section: Introductionmentioning
confidence: 99%
“…Most importantly, MBP contains bound zinc ions, followed by iron, calcium, and copper. Likewise, metalloproteins and metalloenzymes are a widespread class of specific or superfamily of enzymes found in all cells that possess metal ions as cofactors and catalyze a plethora of reactions, such as oxidation, reduction, biosynthesis, and hormone metabolism, for candidate biological pathways ( Dubey et al, 2021 ; Leone et al, 2023 ).…”
Section: Introductionmentioning
confidence: 99%