Natural Deep Eutectic Solvents: From Their Discovery to Their Applications

Vanda, Henni; Verpoorte, Robert; Klinkhamer, Peter G. L.; Choi, Young Hae

doi:10.1002/9783527818488.ch4

Cited by 20 publications

(16 citation statements)

References 60 publications

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“…The combination of sugar and amino acid is a typical classification of NADES, and dissolving the components in a certain ratio in water before subjected to freeze drying is also one of three typical methods to prepare NADES. 22,23 Therefore, both of the NADES preparation (dissolving reactants and lyophilization) and reacting conditions were supposed to have a certain influence on product yield. Our preliminary experiments indicated that besides reacting temperature, changing the initial pH value or initial concentration of glutamic acid could also alter the yield of target compounds.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

“…NADES are safe and environmentally friendly, regarding as a sort of emerging green solvents. 14 It is a good choice to produce edible ARPs at industrial scale. In general, NADES are prepared from two or more natural biocomponents (sugars, amino acids, peptides, organic acids, and other metabolites) through a complicated extended H-bond network of hydrogen bond donor and hydrogen bond acceptor.…”

Section: ■ Introductionmentioning

confidence: 99%

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Maillard Mimetic Food-Grade Synthesis of N-(β-d-Deoxyfructos-1-yl)-l-glutamic Acid and N-(β-d-Deoxyfructos-1-yl)-β-alanyl-l-histidine by a Combination of Lyophilization and Thermal Treatment

Zhang

Zhao

Gao

et al. 2020

J. Agric. Food Chem.

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A typical glycoconjugate of glutamic acid, namely, N-(β-D-deoxyfructos-1-yl)-L-glutamic acid, was successfully synthesized as the primary isomer in a yield of 96.08% using a food-grade preparation method, and its chemical structure was clearly demonstrated by mass spectrometry and 1D/2D NMR. The reaction kinetics of glucose and glutamic acid were systematically studied to investigate the effect of lyophilization and thermal treatment on the conversion of reactants to their corresponding Amadori rearrangement product (ARP). Interestingly, besides the initial pH value, temperature, and heating time, the initial concentration of glutamic acid also influenced the final yield because intramolecular dehydration occurred at the same time, competing with the Maillard reaction and degrading reaction. Moreover, a similar Amadori compound of carnosine was also prepared in a yield of about 66.38% and the yield could be further improved to 95% after condition optimization. One major isomer of the corresponding ARP of the peptide was confirmed to be N-(β-D-deoxyfructos-1-yl)-β-alanyl-L-histidine by structure characterization, indicating that this is a good method to prepare the N-(β-D-deoxyfructos-1-yl)-amino acid/peptide.

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Section: ■ Results and Discussionmentioning

confidence: 99%

Section: ■ Introductionmentioning

confidence: 99%

Maillard Mimetic Food-Grade Synthesis of N-(β-d-Deoxyfructos-1-yl)-l-glutamic Acid and N-(β-d-Deoxyfructos-1-yl)-β-alanyl-l-histidine by a Combination of Lyophilization and Thermal Treatment

Zhang

Zhao

Gao

et al. 2020

J. Agric. Food Chem.

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“…All chemicals were purchased from Sigma-Aldrich and used without further purification. NaDES was obtained via heating: ChLA was prepared with equimolar ratios of choline chloride (ChCl) and lactic acid (LA) [104]. The two components were stirred and heated at 50 • C in a round-bottom flask without adding water until a homogeneous liquid was formed.…”

Section: Appendix A12 Chemicalsmentioning

confidence: 99%

Emerging Processing Technologies for the Recovery of Valuable Bioactive Compounds from Potato Peels

Gaudino

Colletti

Grillo

et al. 2020

Foods

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Potato peel (PP) is the major underutilised by-product in the potato-processing industry and a potential source of valuable bioactive molecules. Among them, glycoalkaloids and polyphenols are important precursors for steroid hormones and natural antioxidants, respectively. Moreover, the huge quantities of industrial potato-peel waste that are produced are a rich source of primary metabolites, which principally include starch as well as non-starch polysaccharides, proteins, lipids, lignin and cellulose. All carbohydrates are prone to undergo fermentation to produce ethanol, lactic and acetic acid. Finally, the main portion of PP is made up of alcohol-insoluble matter with a dietary fibre content of approximatively 40%. The present review summarises the recent advances and emerging technologies in potato-peel extraction and further valorisation processing in the food industry.

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“…Natural deep eutectic solvents (NADES) are under the spotlight as they are potential alternatives for conventional organic solvents [32]. NADES are a new generation of ionic liquids formed by mixing two or more naturally occurring components, such as cholinium chloride, used as a hydrogen bond acceptor, and sugar, alcohol, amino acids, vitamins, organic acids, and organic bases as hydrogen bond donors [32,33]. Since their constituents are naturally occurring, they are inherently nontoxic and environmentally benign [34].…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, studies have shown that NADES have great selectivity in the extraction of target compounds [36,38,39]. Their noncorrosiveness, low flammability, and low preparation costs make them suitable and convenient for use in industry [33,36]. Anthocyanins are conventionally extracted with mixtures of water and ethanol, methanol, and acetone with associated flammability and toxicity risks [24,39].…”

Section: Introductionmentioning

confidence: 99%

Deep Eutectic Solvents and Nonconventional Technologies for Blueberry-Peel Extraction: Kinetics, Anthocyanin Stability, and Antiproliferative Activity

et al. 2020

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Interest in bioactive phytochemicals and sustainable processes is the driving force behind this study on two novel green extraction methods for the recovery of anthocyanins from the residues of blueberry processing. Five natural deep eutectic solvents (NADES) have been tested for anthocyanin extraction. Acidified hydroalcoholic solutions were used as benchmarks and the shelf life of eutectic systems was monitored. The most promising NADES was tested in microwave (MAE)- and ultrasound-assisted extractions (UAEs), and Peleg’s kinetic model was used. Both the enabling technologies provided performance that was superior to that of conventional extraction. MAE and UAE yielded up to 25.83 and 21.18 mg/gmatrix of total anthocyanin content, respectively, after 15 and 30 min. Moreover, a preliminary test for extract concentration and NADES recycling was performed using resin adsorption. Finally, the antiproliferative activity of the extracts was determined by a CellTiter 96® AQueous One Solution Cell Proliferation Assay, the so-called MTS assay, on human tumour HeLa cells and human skin HaCaT cells. Nonconventional extracts exhibited strong antiproliferative activity that was much greater than that of their conventionally extracted analogues. Flow cytometry was used to evaluate cell-death type, and apoptosis was found to be the primary cause of tumour cell death. The presented study demonstrates that the implementation of enabling extraction technologies and green solvents can produce an antiproliferative agent from a food industry byproduct.

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Natural Deep Eutectic Solvents: From Their Discovery to Their Applications

Cited by 20 publications

References 60 publications

Maillard Mimetic Food-Grade Synthesis of N-(β-d-Deoxyfructos-1-yl)-l-glutamic Acid and N-(β-d-Deoxyfructos-1-yl)-β-alanyl-l-histidine by a Combination of Lyophilization and Thermal Treatment

Maillard Mimetic Food-Grade Synthesis of N-(β-d-Deoxyfructos-1-yl)-l-glutamic Acid and N-(β-d-Deoxyfructos-1-yl)-β-alanyl-l-histidine by a Combination of Lyophilization and Thermal Treatment

Emerging Processing Technologies for the Recovery of Valuable Bioactive Compounds from Potato Peels

Deep Eutectic Solvents and Nonconventional Technologies for Blueberry-Peel Extraction: Kinetics, Anthocyanin Stability, and Antiproliferative Activity

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