Natural deep eutectic solvent supported targeted solid–liquid polymer carrier for breast cancer therapy

Sun, Xiaofeng; Pradeepkumar, Periyakaruppan; Rajendran, Naresh Kumar; Shakila, Harshavardhan; Houreld, Nicolette Nadene; Farraj, Dunia A. Al; Elnahas, Yousif M.; Nandhakumar, E.; Rajan, Mariappan

doi:10.1039/d0ra03790g

Cited by 9 publications

(8 citation statements)

References 41 publications

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“…A new type of solid-lipid nanoparticle (SLN) of NADES and biotin-conjugated lysine-polyethylene glycol copolymer were prepared for paclitaxel (PTX) and 7-hydroxycoumarin (7-HC) and characterized for particle size, surface morphology, functional groups, and thermal stability. Both the drug-loaded novel SLN systems exhibited strong anticancer properties of drug molecules in cancer treatment [ 68 ].…”

Section: Pharmaceutical Applications Of Thedesmentioning

confidence: 99%

Pharmaceutical applications of therapeutic deep eutectic systems (THEDES) in maximising drug delivery

Javed,

Mangla,

Sultan

et al. 2024

Heliyon

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Section: Pharmaceutical Applications Of Thedesmentioning

confidence: 99%

Pharmaceutical applications of therapeutic deep eutectic systems (THEDES) in maximising drug delivery

Javed,

Mangla,

Sultan

et al. 2024

Heliyon

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“…Several studies have demonstrated the role of TheDESs in the treatment of dermatological, infectious and metabolic related diseases, such as wound healing, diabetes mellitus, and atherosclerosis [119,120] . Moreover, some eutectic systems showed a cytotoxic effect against a wide range of cancer cell lines [121,122] …”

Section: Role Of Deep Eutectic Solvents In Drug Engineeringmentioning

confidence: 99%

“…[119,120] Moreover, some eutectic systems showed a cytotoxic effect against a wide range of cancer cell lines. [121,122] The APIs must efficiently and specifically reach the site of action to achieve the desired therapeutic effect. However, the obstacles to drug delivery come in different forms and involve poor biopharmaceutical properties of the APIs such as chemical instability, low solubility, low permeability, and rapid metabolism and elimination from the body.…”

Section: Role Of Deep Eutectic Solvents In Drug Engineeringmentioning

confidence: 99%

Deep Eutectic Solvents: An Eco‐friendly Design for Drug Engineering

et al. 2023

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In the spirit of circular economy and sustainable chemistry, the use of environmentally friendly chemical products in pharmacy has become a hot topic. In recent years, organic solvents have been the subject of a great range of restriction policies due to their harmful effects on the environment and toxicity to human health. In parallel, deep eutectic solvents (DESs) have emerged as suitable greener solvents with beneficial environmental impacts and a rich palette of physico‐chemical advantages related to their low cost and biocompatibility. Additionally, DESs can be accompanied by a remarkable solubilizing effect for several active pharmaceutical ingredients (APIs), thus forming therapeutic DESs (TheDESs). In this work, special attention is paid to DESs, presenting a precise definition, classification, methods of preparation, and characterization. A description of natural DESs (NaDESs), i.e., eutectic solvents present in natural sources, is also reported. Moreover, the present review article is the first one to detail the different approaches for judiciously selecting the constituents of DESs in order to minimize the number of experiments. The role of DESs in the biomedical and pharmaceutical sectors and their impact on the development of successful therapies are also discussed.

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“…They are mostly made of synthetic polymers and not liquid-based carriers, which sometimes compromises certain uses [54]. However, researchers are now exploring new carrier systems using ILs and DESs, although these have limitations, such as thermal instability, low drug loading levels, and low drug release and solubility [61].…”

Section: Small But Mighty: How Nanocarriers Are Revolutionizing Drug ...mentioning

confidence: 99%

From Nature to Innovation: The Uncharted Potential of Natural Deep Eutectic Solvents

Schuh,

Reginato,

Florêncio

et al. 2023

Molecules

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This review discusses the significance of natural deep eutectic solvents (NaDESs) as a promising green extraction technology. It employs the consolidated meta-analytic approach theory methodology, using the Web of Science and Scopus databases to analyze 2091 articles as the basis of the review. This review explores NaDESs by examining their properties, challenges, and limitations. It underscores the broad applications of NaDESs, some of which remain unexplored, with a focus on their roles as solvents and preservatives. NaDESs’ connections with nanocarriers and their use in the food, cosmetics, and pharmaceutical sectors are highlighted. This article suggests that biomimicry could inspire researchers to develop technologies that are less harmful to the human body by emulating natural processes. This approach challenges the notion that green science is inferior. This review presents numerous successful studies and applications of NaDESs, concluding that they represent a viable and promising avenue for research in the field of green chemistry.

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Natural deep eutectic solvent supported targeted solid–liquid polymer carrier for breast cancer therapy

Abstract: Solid–liquid nanocarriers (SLNs) are at the front of the rapidly emerging field of medicinal applications with a potential role in the delivery of bioactive agents.

Cited by 9 publications

References 41 publications

Pharmaceutical applications of therapeutic deep eutectic systems (THEDES) in maximising drug delivery

Pharmaceutical applications of therapeutic deep eutectic systems (THEDES) in maximising drug delivery

Deep Eutectic Solvents: An Eco‐friendly Design for Drug Engineering

From Nature to Innovation: The Uncharted Potential of Natural Deep Eutectic Solvents

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