2014
DOI: 10.4049/jimmunol.192.supp.138.7
|View full text |Cite
|
Sign up to set email alerts
|

Natural cytotoxic antibodies against tumor N-glycolilated ganglioside decrease with age and are absent in NSCLC patients (TUM4P.906)

Abstract: N-glycolylated (NeuGc) gangliosides are not naturally expressed in normal human tissues but are overexpressed in several tumors and have immunosuppressive capacity, contributing to cancer progression. The present work shows the existence of a natural antibody response against NeuGcGM3 in healthy donors. These antibodies specifically recognized NeuGcGM3 and killed tumor cells expressing the antigen by a complement mediated mechanism. Interestingly, even after complement inactivation 17% of the positive sera sho… Show more

Help me understand this report

This publication either has no citations yet, or we are still processing them

Set email alert for when this publication receives citations?

See others like this or search for similar articles