Natural course of severe temporomandibular joint osteoarthrosis evaluated by a novel condylar remodelling scoring system and quantitative volumetric analysis

Sun, C.-K.; Li, Y.-B.; Ma, Hongsheng; Li, G.; Sun, Z.-P.; Sun, L.

doi:10.1016/j.ijom.2022.08.001

Cited by 4 publications

(7 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The presence of a continuous cortex determined the absence of notable volumetric losses at a mean 2 years follow-up. 6 Although most areas of cortical erosion (74.4%) converted into continuous cortex during this period, the mean volume loss was close to 15%. Mandibular condyle cortical line continuity and density were also related to condylar volume changes after orthognathic surgery.…”

Section: Discussionmentioning

confidence: 77%

“… 5 Studies of the natural course of severe TMJ osteoarthritis also showed that most discontinuous cortex erosions are converted to continuous ones for up to 2 years. However, there is also an increased probability of condylar volume reduction by resorption, 6 even when they are conservatively treated 7 …”

Section: Introductionmentioning

confidence: 99%

“…The evidence of different etiologies of condylar resorption is relatively low, and its clinical features are comparable to those of severe degenerative joint diseases. 6 This resorption is one of the significant post-surgical complications of orthognathic surgery, and the resorption degree of condylar height is related to post-operative skeletal relapse. 8 Risk factors for condylar resorption following orthognathic surgery include disc displacements and degenerative lesions before treatment 9 especially when mandibular advancement associated with counterclockwise rotation is done.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Nasal septum-derived chondroprogenitor cells control mandibular condylar resorption consequent to orthognathic surgery: a clinical trial

Tesch,

Takamori,

Menezes

et al. 2024

Stem Cells Translational Medicine

View full text Add to dashboard Cite

Condylar resorption is an aggressive and disability form of temporomandibular joint (TMJ) degenerative disease, usually non-respondent to conservative or minimally invasive therapies and often leading to surgical intervention and prostheses implantation. This condition is also one of the most dreaded postoperative complications of orthognathic surgery, with severe cartilage erosion and loss of subchondral bone volume and mineral density, associated with a painful or not inflammatory processes. Because regenerative medicine has emerged as an alternative for orthopedic cases with advanced degenerative joint disease, we conducted a phase I/IIa clinical trial (U1111-1194-6997) to evaluate the safety and efficacy of autologous nasal septal chondroprogenitor cells. Ten participants underwent biopsy of the nasal septum cartilage during their orthognathic surgery. The harvested cells were cultured in vitro and analyzed for viability, presence of phenotype markers for mesenchymal stem and/or chondroprogenitor cells, and the potential to differentiate into chondrocytes, adipocytes, and osteoblasts. After the intra-articular injection of the cell therapy, clinical follow-up was performed using the Diagnostic Criteria for Temporomandibular Disorders (DC/TMD) and computed tomography (CT) images. No serious adverse events related to the cell therapy injection were observed during the 12-month follow-up period. It was found that autologous chondroprogenitors reduced arthralgia, promoted stabilization of mandibular function and condylar volume, and regeneration of condylar tissues. This study demonstrates that chondroprogenitor cells from the nasal septum may be a promise strategy for the treatment of temporomandibular degenerative joint disease that do not respond to other conservative therapies.

show abstract

Section: Discussionmentioning

confidence: 77%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Nasal septum-derived chondroprogenitor cells control mandibular condylar resorption consequent to orthognathic surgery: a clinical trial

Tesch,

Takamori,

Menezes

et al. 2024

Stem Cells Translational Medicine

View full text Add to dashboard Cite

show abstract

“…Nevertheless, the question of whether speci c clinical features are linked to an increased risk of developing SBAs remains a matter of debate. Some authors failed to establish a correlation between TMJ pain parameters and CBCT-observed TMJ condylar SBA changes [8, [17][18][19][20][21], while others reported a signi cant association between TMJ pain ndings and those of TMJ condylar SBA alterations [22][23][24][25][26][27][28]. They found a signi cant relationship between TMJ pain and dysfunction parameters and condylar resorption [22], overall destructive changes [23], osteophytes and attening [28], and categorized condylar SBA changes [24][25][26][27].…”

Section: Introductionmentioning

confidence: 99%

“…Previously, most research has involved simple pairwise tests of TMJ CBCT imaging variables [8, [17][18][19][20][21][22][23][24][25], assuming an "all or none" role and disregarding the simultaneous in uence of multiple factors inherent in biological systems. To the best of the authors' knowledge, there are no CBCT studies that address the role of clinical parameters in de ning speci c condylar SBA features in a multivariate design.…”

Section: Introductionmentioning

confidence: 99%

Risk factors for subchondral bone alterations in TMJ arthralgia: a retrospective multivariate CBCT study

Emshoff,

Rudisch,

Bertram

2023

Preprint

View full text Add to dashboard Cite

Background Temporomandibular joint (TMJ) osteoarthritis (OA) is a progressive degenerative joint disorder characterized by loss of cartilage and alterations in subchondral bone architecture. Prospective studies using multivariable analysis to identify risk factors for subchondral bone alterations (SBAs) are lacking. The aim of this study was to identify clinical baseline predictors mostly associated with the severity of TMJ condylar SBAs. Methods This retrospective paired-design study enrolled 233 consecutive TMJ pain patients. TMJ pain patients were classified according to the diagnostic criteria for temporomandibular disorders (DC/TMD) Axis I protocol. Following clinical examination, each patient underwent cone beam computed tomography (CBCT) evaluation of both TMJs. A composite condylar SBA grading score was created from the following items: erosion, resorption, cyst, sclerosis, osteophyte, and flattening; the maximum possible score was 4. Multivariate ordinal regression analysis identified baseline predictors of CBCT condylar SBA grades. Results The study group included 87.6% women, and the overall average age of the study population was 41.9 ± 18.1 years. The following factors were significantly associated with the severity of condylar SBAs: older age (> 45 years) (odds ratio [OR], 4.53; p < 0.001), having concomitant arthralgia (OR, 1.85; p = 0.035), and higher number of missing posterior teeth (> 4) (OR, 1.80; p = 0.039). Gender (p = 0.080) and time since pain onset (p < 0.05) had no significant association with condylar SBA grade. Conclusions Older patients with missing posterior teeth who have a concurrent arthralgia should be advised of their increased risk of developing SBAs. Delayed diagnosis and treatment can be avoided by focusing on these risk factors.

show abstract

Annual review of selected scientific literature: A report of the Committee on Scientific Investigation of the American Academy of Restorative Dentistry

Cagna¹,

Donovan²,

McKee³

et al. 2023

The Journal of Prosthetic Dentistry

View full text Add to dashboard Cite

Natural course of severe temporomandibular joint osteoarthrosis evaluated by a novel condylar remodelling scoring system and quantitative volumetric analysis

Cited by 4 publications

References 20 publications

Nasal septum-derived chondroprogenitor cells control mandibular condylar resorption consequent to orthognathic surgery: a clinical trial

Nasal septum-derived chondroprogenitor cells control mandibular condylar resorption consequent to orthognathic surgery: a clinical trial

Risk factors for subchondral bone alterations in TMJ arthralgia: a retrospective multivariate CBCT study

Annual review of selected scientific literature: A report of the Committee on Scientific Investigation of the American Academy of Restorative Dentistry

Contact Info

Product

Resources

About