Natural course of intra-articular shifting bone marrow edema syndrome of the knee

Aigner, N; Meizer, R; Petje, G.; Meizer, E; Abdelkafy, Ashraf; Landsiedl, F

doi:10.1186/1471-2474-9-45

Cited by 16 publications

(12 citation statements)

References 25 publications

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“…BME is usually self-limiting in the nature course and the symptoms resolve spontaneously over a period of 6 months, or occasionally 12 months, [ 7 ] which is invariably associated with severe and long-lasting disability. [ 8 , 9 ] Various treatments have been recommended in order to shorten the natural course of the disease.…”

Section: Introductionmentioning

confidence: 99%

Extracorporeal shock wave treatment can normalize painful bone marrow edema in knee osteoarthritis

Kang

Gao²,

Jin³

et al. 2018

Medicine

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Bone marrow edema (BME) represents a reversible but highly painful finding in magnetic resonance imaging (MRI) of patients with knee osteoarthritis. The aim of this retrospective study was to evaluate the efficacy of extracorporeal shock wave treatment (ESWT) on painful BME in osteoarthritis of the knee.This study focuses on people who had early-to-mid stage osteoarthritis with knee pain and MRI findings of BME. Patients who underwent ESWT treatment or prescribed alendronate treatment in our department were analyzed. Knee pain and function were measured using the visual analog scale (VAS) for pain and the Western Ontario and McMaster University Osteoarthritis Index (WOMAC), respectively. The degree of BME was measured with MRI scans.A total of 126 patients who received ESWT treatment (Group A, n = 82) or alendronate treatment (Group B, n = 44) were included. All patients were followed up clinically and radiographically for a minimum of 12 months. The mean follow-up was 23.5 months (range, 12–38 months). The VAS and WOMAC score decreased more significantly after treatment in Group A than that in Group B (P <.01) within 3 months. In 6-month MRI follow-ups, there was higher incidence of distinct reduction and complete regression of BME of the affected knee in Group A than that in Group B (P <.01).ESWT is an effective, reliable, and noninvasive treatment in patients with painful BME in osteoarthritis of the knee followed by a rapid normalization of the MRI appearance. It has the potential to shorten the natural course of this disease.

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Section: Introductionmentioning

confidence: 99%

Extracorporeal shock wave treatment can normalize painful bone marrow edema in knee osteoarthritis

Kang

Gao²,

Jin³

et al. 2018

Medicine

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“…The recurrence of symptoms in an adjacent joint or intra-articular migration in the same joint is a characteristic clinical and radiological feature of migrating BMES. 6 Migration of BMES lesions within different compartments of the same joint is rare, and development of BMES in the foot is even rarer. 6,7 The present case is distinctive because the signs of BMES occurred in a patient with BD, and BMES recurred in the same foot three times.…”

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confidence: 99%

“…6 Migration of BMES lesions within different compartments of the same joint is rare, and development of BMES in the foot is even rarer. 6,7 The present case is distinctive because the signs of BMES occurred in a patient with BD, and BMES recurred in the same foot three times. BMES involves diffuse subacute ischemia and is resolved completely in most patients who have a sufficient repair mechanism.…”

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confidence: 99%

A case of migrating bone marrow edema syndrome in a patient with Behcet's disease

et al. 2014

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“…6 For bone marrow edema syndrome, thrombembolism, obstruction of arteriolar inflow or venous outflow, injury to the vessel wall secondary to vasculitis, altered lipid metabolism, and reduced fibrinolysis have been suggested as etiologic factors. 7 Some authors have postulated that bone marrow edema syndrome might be a reversible or a prestage form of osteonecrosis. 8,9 For both entities, several studies have indicated that coagulation abnormalities causing thrombophilia or hypofibrinolysis might contribute to the emergence of these entities.…”

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confidence: 99%

Coagulation Abnormalities in Osteonecrosis and Bone Marrow Edema Syndrome

Orth

Anagnostakos²

2013

Orthopedics

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The aim of this review was to provide information about the variety of thrombophilic and hypofibrinolytic markers that are possible risk factors for the development of osteonecrosis and bone marrow edema syndrome. A total of 48 parameters were identified in 45 studies that included 2163 patients. The most frequently reported laboratory findings included altered serum concentrations of lipoproteins, decreased concentration and function of fibrinolytic agents, increased levels of thrombophilic markers, and several single nucleotide polymorphisms. Despite inhomogeneities in reported parameters, results, patients' collectives, and treatment strategies, these data suggest that coagulation abnormalities may play an important role in the emergence of osteonecrosis and bone marrow edema syndrome.

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Natural course of intra-articular shifting bone marrow edema syndrome of the knee

Abstract: Background: Intra-articular shift (migration) of bone marrow edema syndrome (BMES) is a very rare disease. Only a few cases have been reported thus far. The condition may cause the clinician to suspect an aggressive disease.

Cited by 16 publications

References 25 publications

Extracorporeal shock wave treatment can normalize painful bone marrow edema in knee osteoarthritis

Extracorporeal shock wave treatment can normalize painful bone marrow edema in knee osteoarthritis

A case of migrating bone marrow edema syndrome in a patient with Behcet's disease

Coagulation Abnormalities in Osteonecrosis and Bone Marrow Edema Syndrome

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