Natural coumarins: Preclinical evidence-based potential candidates to alleviate diabetic nephropathy

Ghosh, Sitara; Ghosh, Ankana; Rajanan, Ashitha; Suresh, Amal Jyothy; Raut, Pratiksha Sharadrao; Kundu, Sourav; Sahu, Bidya Dhar

doi:10.1016/j.phyplu.2022.100379

Cited by 7 publications

(4 citation statements)

References 183 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The production of advanced glycation end products (AGEs), the disruption of proinflammatory cytokines, and the activation of cellular pathways, such as the TGF-β/Smad, NF-kB (p65), and NLRP3/Caspase 1 axis, have all been reported to be decreased by coumarins [ 75 , 76 ]. According to the mounting evidence, coumarins may also prevent the kidneys from producing extracellular matrix components, and from activating myofibroblasts that secrete α-smooth muscle action [ 77 ].…”

Section: Discussionmentioning

confidence: 99%

Protective Action Mechanisms of Launaea mucronata Extract and Its Nano-Formulation against Nephrotoxicity in Rats as Revealed via Biochemical, Histopathological, and UPLC-QTOF–MS/MS Analyses

et al. 2023

View full text Add to dashboard Cite

Plants belonging to the Launaea genus have been extensively utilized ethnopharmacologically to treat a variety of diseases, including kidney disorders. Chromium is a common industrial pollutant that has been linked to kidney disease. The present work was designed for the investigation of the UPLC-QTOF–MS/MS metabolite profile of the L. mucronate ethanolic extract (LME), along with assessing the mechanistic protective actions of LME and its nano-silver formulation (LMNS) against K2Cr2O7-induced nephrotoxicity in rats. LMNE was successfully biosynthesized and confirmed using UV–Visible (UV–Vis) spectroscopy and transmission electron microscopy (TEM). The nephroprotective effects of LME and LMNE was assessed in rats exposed to potassium dichromate (K2Cr2O7, 15 mg/kg BW) to cause nephrotoxicity. LME and LMNS, separately, were administered twice daily for 14 days at doses of 200 and 400 mg/kg BW, respectively. The kidney function, catalase, UGT, Nrf2, PGE2, Cox-2, ERK, and MAPK levels in renal tissue were all assessed, along with histopathological examinations for exploring their ameliorative effects. Forty-five bioactive metabolites were annotated belonging to flavonoids, phenolic and organic acids, coumarins, and fatty acids. Metabolite profiling revealed that chlorogenic acid, apigenin, and luteolin glycosides were the main phenolics, with chlorogenic acid-O-hexoside reported for the first time in LME. The findings revealed that the serum kidney function indicators (urea and creatinine) were markedly elevated in K2Cr2O7-intoxicated rats. Furthermore, inflammatory indicators (COX-2 and PGE2), MAPK, and ERK were all markedly elevated in kidney tissue, whereas catalase, UGT, and Nrf2 levels were downregulated. Histological and immunohistochemical assays confirmed the toxic effects of K2Cr2O7 in the kidneys. In contrast, the administration of LME and LMNS prior to K2Cr2O7 considerably improved the architecture of the renal tissue, while also restoring levels of most biochemical markers. Functioning via the inhibition of the MAPK/ERK pathway, activating Nrf2, and modifying the antioxidant and metabolic enzymes, LME and LMNS exerted their nephroprotective effects against K2Cr2O7-induced toxicity.

show abstract

Section: Discussionmentioning

confidence: 99%

Protective Action Mechanisms of Launaea mucronata Extract and Its Nano-Formulation against Nephrotoxicity in Rats as Revealed via Biochemical, Histopathological, and UPLC-QTOF–MS/MS Analyses

et al. 2023

View full text Add to dashboard Cite

show abstract

“…Esculin amelioration of unhealthy AT remodeling was also proven for the first time as a novel therapeutic strategy for obesityinduced IR. Intervention with esculin could enhance insulin sensitivity and improve adipose tissue remodeling in obese IR C57BL/6J mice (Ghosh et al, 2022). In PA-treated adipocytes, esculin could promoted glucose uptake through increasing the enhancement of GLUT4 translocation and the expression of p-PI3K p85 Tyr467 , p-AKT Ser473 , and p-IRS1 Ser307 (Yang et al, 2024).…”

Section: Esculinmentioning

confidence: 96%

Metabolites of traditional Chinese medicine targeting PI3K/AKT signaling pathway for hypoglycemic effect in type 2 diabetes

Feng,

Ren,

Zhang

et al. 2024

Front. Pharmacol.

View full text Add to dashboard Cite

Type 2 diabetes mellitus is a chronic metabolic disease characterized by insulin resistance, with high morbidity and mortality worldwide. Due to the tightly intertwined connection between the insulin resistance pathway and the PI3K/AKT signaling pathway, regulating the PI3K/AKT pathway and its associated targets is essential for hypoglycemia and the prevention of type 2 diabetes mellitus. In recent years, metabolites isolated from traditional Chinese medicine has received more attention and acceptance for its superior bioactivity, high safety, and fewer side effects. Meanwhile, numerous in vivo and in vitro studies have revealed that the metabolites present in traditional Chinese medicine possess better bioactivities in regulating the balance of glucose metabolism, ameliorating insulin resistance, and preventing type 2 diabetes mellitus via the PI3K/AKT signaling pathway. In this article, we reviewed the literature related to the metabolites of traditional Chinese medicine improving IR and possessing therapeutic potential for type 2 diabetes mellitus by targeting the PI3K/AKT signaling pathway, focusing on the hypoglycemic mechanism of the metabolites of traditional Chinese medicine in type 2 diabetes mellitus and elaborating on the significant role of the PI3K/AKT signaling pathway in type 2 diabetes mellitus. In order to provide reference for clinical prevention and treatment of type 2 diabetes mellitus.

show abstract

“…Coumarins, secondary metabolites present in various plants, comprise aromatic heterocyclic structures characterized by fused benzene and αpyrone rings. Among their notable properties, coumarins demonstrate hypoglycemic activity and exhibit inhibitory effects on the enzyme aldose reductase and platelet aggregation (Ghosh et al, 2022). These actions are particularly significant as they are believed to underlie the mechanisms behind diabetic complications (Venugopala et al, 2013).…”

Section: Coumarinsmentioning

confidence: 99%

Antidiabetic activity of some common medicinal plants

Elbakry,

Elremaly

2023

Biological and Biomedical Journal

View full text Add to dashboard Cite

Diabetes mellitus (DM) is a chronic metabolic disease characterized by elevated blood sugar, malfunctional insulin, resistance, and lipid metabolism. DM is a major global health that causes a burden on the individual and society. Despite advances in clinical management, late-onset complications of diabetes remain challenging to control. Antidiabetic medications can cause weight gain or loss, and adverse gastrointestinal effects, highlighting the need for alternative, effective therapies with fewer side effects. Natural products have been widely investigated as antidiabetic agents, and many have been shown to have direct or indirect effects on DM pathways. These products contain chemical components, such as flavonoids, terpenes, alkaloids, coumarins, and phenolic compounds, which may be used to develop new antidiabetic drugs. This review provides an overview of the evidence surrounding some commonly used natural products that affect DM management.

show abstract

Natural coumarins: Preclinical evidence-based potential candidates to alleviate diabetic nephropathy

Cited by 7 publications

References 183 publications

Protective Action Mechanisms of Launaea mucronata Extract and Its Nano-Formulation against Nephrotoxicity in Rats as Revealed via Biochemical, Histopathological, and UPLC-QTOF–MS/MS Analyses

Protective Action Mechanisms of Launaea mucronata Extract and Its Nano-Formulation against Nephrotoxicity in Rats as Revealed via Biochemical, Histopathological, and UPLC-QTOF–MS/MS Analyses

Metabolites of traditional Chinese medicine targeting PI3K/AKT signaling pathway for hypoglycemic effect in type 2 diabetes

Antidiabetic activity of some common medicinal plants

Contact Info

Product

Resources

About